New Emmy Noether Independent Junior Research Group at the Faculty of Law examines EU solidarity conflicts
FRANKFURT. A new Emmy Noether Independent Junior Research Group has started work at the Faculty of Law of Goethe University Frankfurt. The team headed by Dr. Anuscheh Farahat is dealing with the role played by constitutional courts in transnational solidarity conflicts.
The global financial crisis has severely disadvantaged countries in the European Union too – and some of them have still not recovered today. To rescue the euro, the European Member States were obliged to get a grip on the debts of countries such as Greece, Spain or Portugal. This demanded and continues to demand a lot of transnational solidarity. However, coping with the crisis leads time and again to conflicts in creditor and debtor countries since it raises legal issues on both sides. For example, Germany’s Federal Constitutional Court had to clarify, amongst others, to what extent the Bundestag (the German parliament) is obliged to approve Germany’s participation in relief actions; after all, budget decisions are down to parliament. In Portugal, on the other hand, what were referred to as “Troika measures”, which foresaw sharp cutbacks in employees’ income, landed before the national constitutional court, which was asked to clarify whether measures such as salary and pension cuts in the civil service were consistent with the constitution.
Are the courts the right institution to resolve such questions? Or might it not be the responsibility of a European-level entity or the parliaments? Or how else could the national courts be persuaded to take the perspective of other affected countries into account in their decisions? It is questions such as these which are being tackled by the new Emmy Noether research project “Transnational Solidarity Conflicts: Constitutional Courts as Fora for and Players in Conflict Resolution” that started recently. Project leader Dr. Anuscheh Farahat is convinced: “The crisis in the EU is in actual fact a crisis of transnational solidarity.” That is why she is investigating distribution and recognition conflicts in her project, which have become exacerbated in the EU during the course of the economic and financial crisis. Her work centres on what role national and European constitutional courts have played in these conflicts. How was the destructive potential of these conflicts institutionally channelled? Could new social order be brought about in the process? Or are other structures needed?
The Emmy Noether Independent Junior Research Group, which is made up of three early career researchers, will receive € 900,000 in funding from the German Research Foundation, initially until February 2020. Project leader Anuscheh Farahat studied in Frankfurt, Paris and Berkeley and completed her doctoral degree in 2011 at Goethe University Frankfurt with a thesis on migration law that has been awarded numerous prizes. In 2014 she became Senior Research Fellow at the Max Planck Institute for Comparative Public Law and International Law in Heidelberg. Her research interests are European and German constitutional law, German and international migration law as well as comparative constitutional law. A main focus of her current research work is questions related to the organization of public authority in transnational judicial areas.
A picture can be downloaded from: www.uni-frankfurt.de/66895847
Caption: Dr. Anuscheh Farahat heads the new Emmy Noether Independent Junior Research Group at Goethe University Frankfurt. She is investigating the role of constitutional courts in European solidarity conflicts. Photo: MPIL/Maurice Weiss
Further information: Dr. Anuscheh Farahat, email@example.com
Anesthetics cause certain areas of the brain to generate less information
FRANKFURT. To date, researchers assumed that anesthetics interrupt signal transmission between different areas of the brain and that is why we lose consciousness. Neuroscientists at Goethe University Frankfurt and the Max Planck Institute for Dynamics and Self-Organization in Göttingen have now discovered that certain areas of the brain generate less information when under anesthesia. The drop in information transfer often measured when the brain is under anesthesia could be a consequence of this reduced local information generation and not – as was so far assumed – a result of disrupted signal transmission between brain areas.
If only a few telephone calls are made in a city then it could be the case that several telecommunication systems have broken down – or it is nighttime and most people are asleep. The situation is similar in an anesthetized brain: if there is remarkably little information transfer between various areas of the brain then either signal transmission in the nerve fibers is blocked or certain areas of the brain are less active as far as the generation of information is concerned.
Patricia Wollstadt, Favio Frohlich, their colleagues from the Brain Imaging Center at Goethe University Frankfurt and researchers at the MPI for Dynamics and Self-Organization have now investigated this second hypothesis. As they have announced in the current issue of “PLOS Computational Biology”, they used ferrets to examine “source” brain areas from which less information was transmitted under anesthesia than in a waking state. They found that information generation under anesthesia was far more affected there than in the “target” brain areas to which the information was transferred. This indicates that it is the information available in the source area which determines information transfer and not a disruption in signal transmission. Were the latter the case, a far greater reduction could be expected in the target areas since less information “arrives” there.
“The relevance of this alternative explanation goes beyond anesthesia research, says Patricia Wollstadt, “since each and every examination of neuronal information transfer should categorically take into consideration how much information is available locally and is therefore also transferable.”
Publication: Patricia Wollstadt, Kristin K. Sellers, Lucas Rudelt, Viola Priesemann, Axel Hutt, Flavio Fröhlich, Michael Wibral: Breakdown of local information processing may underlie isoflurane anesthesia effects, in PLOS Computational Biology, http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005511
A picture can be downloaded from: www.uni-frankfurt.de/66792186
Photo: Stefan_Schranz/ pixabay, CC 0
Further information: Prof. Dr. Michael Wibral, Brain Imaging Center, Faculty of Medicine, Frankfurt University Hospital, Tel.: +49(0)69-6301-83193, firstname.lastname@example.org
German Research Foundation approves Collaborative Research Centre on the topic of matter under extreme conditions in cooperation with the universities in Darmstadt and Bielefeld / CRC in medicine extended
FRANKFURT. The German Research Foundation (DFG) has approved a new Transregio Collaborative Research Centre (CRC/TR) in which physicists from Goethe University Frankfurt, Bielefeld University and TU Darmstadt want to explore together “strongly interacting matter under extreme conditions”. The researchers had submitted an application for around€8 million for the next four years for this. Spokesperson for the new research alliance, which within the partnership with TU Darmstadt is also supporting the Strategic Alliance of Rhine-Main Universities (RMU) launched at the end of 2015, is Frankfurt physicist Professor Dirk Rischke.
“Extreme conditions” means high temperatures and densities such as occurred, for example, in the first millionth of a second after the Big Bang: A few billion degrees Celsius (a hundred thousand times hotter than the Sun’s interior) as well as multiples of the density reached in atomic nuclei (several 100 million tons per cubic centimetre). Under these conditions, matter is dominated by what is known as strong interaction. This is one of the four fundamental forces in physics. It is responsible, amongst others, for the proton and neutron composition of atomic nuclei and for their inner structure of quarks and gluons.
Under extreme conditions, strongly interacting matter forms new types of state, comparable with the various aggregate states of water as ice, liquid and gas. Whilst this is being explored experimentally on large-scale particle accelerators such as the LHC at CERN in Geneva and in future on FAIR in Darmstadt, the new CRC/TR wants to examine the topic from a theoretical perspective.
The intention is to investigate the fundamental properties of strongly interacting matter in the framework of 14 sub-projects and apply them to the physics of the early Universe and in heavy ion experiments. The declared objective here is to start as directly as possible from the fundamental theory of strong interaction, i.e. quantum chromodynamics (QCD). This theory, for the study of which several Nobel prizes have already been awarded, has been known for over 40 years. It has, however, nonetheless proven difficult in many cases to make concrete predictions in the framework of QCD. Deriving in particular the properties of macroscopic concentrations of strongly interacting particles at high temperatures and densities from QCD was so far unsatisfactory.
What is unique about the new CRC/TR is the combination of analysis-based methods with complex numerical simulations on supercomputers of the highest performance class (“Lattice QCD”). “We are working closely together on this in order to make the best possible use of the individual approaches and different expertise at the three universities”, emphasizes Professor Dirk Rischke of Goethe University Frankfurt, the CRC’s spokesperson. Professor Jochen Wambach from TU Darmstadt, who together with Professor Frithjof Karsch from Bielefeld University is Rischke’s deputy, adds: “Many of us have known each other for a long time and have worked together successfully in the past too. However, this Transregio project is taking our collaboration to a new level.”
All three universities are equal partners and this is underlined by the fact that they have already agreed to rotate the role of CRC/TR spokesperson after each funding period, should it be successfully extended. “The complex theoretical questions as well as the experiments currently taking place or already planned in this field of research, where a lot is happening in other countries too, will stimulate a wide spectrum of research projects over the coming decade”, says Karsch. “That’s why we’re convinced we can fill the maximum 12-year duration of a CRC with interesting projects”, agree Rischke, Karsch and Wambach.
CRC in medicine extended
A CRC in the field of medicine has been extended. In the framework of CRC 1039 “Signalling by fatty acid derivatives and sphingolipids in health and disease” researchers are investigating what significance lipids (fat molecules) have as signalling molecules and how they are involved in disease processes. This means that the collaboration between Goethe University Frankfurt and the Max Planck Institute for Heart and Lung Research in Bad Nauheim can continue for the next four years.
Numerous findings in recent years indicate that lipid metabolism disorders contribute to the development and progression of diseases such as arteriosclerosis, diabetes, cancer, inflammatory conditions, pain and neurodegenerative diseases. They are therefore suitable drug targets.
In the first funding period, the researchers concentrated on examining the synthesis and degradation pathways of molecules that intervene in healthy as well as disrupted lipid metabolism. The intention now in the second funding phase is to investigate these molecules, which are known as lipid mediators, in relation to specific diseases such as acute and chronic inflammatory conditions, pain or tumour development. “We want to advance research in the direction of functional consequences as well as of diagnostic and therapeutic implementation, both experimentally as well as clinically,” says Professor Josef Pfeilschifter, CRC spokesperson.
A picture can be downloaded from: www.uni-frankfurt.de/66712830
Caption: Researchers in the new CRC/TR from Bielefeld, Darmstadt and Frankfurt. In the first row: Spokesperson Prof. Dirk Rischke, Goethe University Frankfurt (centre) and deputy spokespersons Prof. Jochen Wambach, TU Darmstadt (second from the right) and Prof. Frithjof Karsch, Bielefeld University (second from the left). Photo: Hauke Sandmeyer (Bielefeld University)
Further information: Prof. Dr. Dirk Rischke, Institute of Theoretical Physics, Faculty of Physics, Riedberg Campus, Tel.: +49(0)69-798-47862, email@example.com.
Prof. Josef Pfeilschifter, Tanja Giesbrecht (secretary), Institute of General Pharmacology and Toxicology, Faculty of Medicine, Niederrad Campus, Tel.: +49(0)69-6301-6991, firstname.lastname@example.org
Researchers at Goethe University Frankfurt have successfully combined two very advanced fluorescence microscopy techniques
Is it possible to watch at the level of single cells how fish embryos become trout, carp or salmon? Researchers at Goethe University Frankfurt have successfully combined two very advanced fluorescence microscopy techniques. The new high-resolution light microscope permits fascinating insights into a cell’s interior.
Using the “light-sheet microscopy” technology invented and developed by Professor Ernst Stelzer, it was already possible to observe organisms in a very precise and vivid way during cell differentiation. His group at Goethe University Frankfurt has now combined light sheets with a technique which so far only allowed very high spatial resolutions (<100nm) on a cell’s surface. Combining both methods makes it possible to obtain a three-dimensional insight into a cell with a high resolution.
Light-sheet-based fluorescence microscopy (LSFM) is the most recent three-dimensional fluorescence microscopy technique. In fluorescence microscopy, a fraction of a cell’s molecules is labelled with fluorescent markers, which are lit up with a beam of light. A camera records the three-dimensional distribution of the fluorescing molecules, i.e. the fluorophores. The outstanding advantage of LSFM is that even sensitive samples such as fish embryos survive observation. This is a major advancement since conventional methods, which illuminate the whole sample, expose the specimens to much more energy and destroy the cells in a very short period of time.
Ernst Stelzer, professor at the Institute of Cell Biology and Neuroscience and a principal investigator in the Cluster of Excellence “Macromolecular Complexes” of Goethe University Frankfurt, explains that LSFM does not illuminate the entire sample but only micrometre-thin light sheets. “Since we examine the biological specimens under conditions that are as natural as possible, we achieve very precise results”, says Stelzer. However, not only static images of cells but also dynamic changes in their environment or genetic mutations can be measured in direct comparisons.
Bo-Jui Chang, Victor Perez Meza and Ernst Stelzer have now improved the technique further: “We combined light-sheet fluorescence microscopy with coherent structured illumination microscopy (SIM). This allows for an extremely high resolution”, he reports. SIM is a super-resolution technique that produces several images, which are combined digitally. As a result, resolution is improved in the physical sense. The technical approach is to excite a fluorescing sample with a very specific illumination pattern. Sub-100 nm resolutions with this method are limited to surfaces but the technique has major advantages. It is fairly moderate in the excitation of the fluorescence, allows very fast imaging and can be used with all fluorescing molecules for high-resolution purposes.
“In the new microscope, which we call csiLSFM, we have developed the principle of SIM further in such a way that sub-100 nm resolutions are no longer limited to surfaces but can also be used in extensive three-dimensional objects. Here, two counterpropagating light sheets interfere at an angle of 180° so that they form the smallest possible linear interference pattern. As a result, we achieve an optimal resolution of less than 100 nanometres,” explains Ernst Stelzer. The new instrument has three objective lenses. It works via the flexible control of rotation, frequency and phase shift of the perfectly modulated light sheet.
Images of endoplasmic reticulum of yeast, a complex membrane network of tubules, vesicles and cisterns, show that the researchers can use csiLSFM to work successfully with physiologically important objects.
Publication: Chang BJ, Perez Meza VD, Stelzer EHK (2017) csiLSFM combines light-sheet fluorescence microscopy and coherent structured illumination for a lateral resolution below 100 nm. Proc Natl Acad Sci U S A, 114(19):4869-4874. doi: 10.1073/pnas.1609278114 (2017 May 9). Epub 2017 Apr 24.
A picture can be downloaded under: http://www.uni-frankfurt.de/66612661
Caption: Live yeast cell embedded in agarose. From left to right: conventional fluorescence, conventionally treated and with csiLSFM. The bar is 1 µm wide.
Photo: Stelzer Research Group, Goethe University Frankfurt
Further information: Prof. Dr. Ernst H. K. Stelzer, Institute of Cell Biology and Neuroscience, Buchmann Institute for Molecular Life Sciences,
Faculty of Biological Sciences, Riedberg Campus, Tel.: +49 (69) 798 42547/42545, email@example.com
State of Hesse grants funds of about € 525,000 for research against forgetting
Frankfurt. Boris Rhein, Minister for Science and the Arts, today introduced the holder of Germany’s first chair for research on the history and impact of the Holocaust, Professor Sybille Steinbacher, and welcomed her to her new post. Sybille Steinbacher took up office on 1 May as Director of the Fritz Bauer Institute. The position is linked to the new “Chair for Research on the History and Impact of the Holocaust” at Goethe University Frankfurt. The State of Hesse is sponsoring the Fritz Bauer Institute with € 375,100 this year and financing the Holocaust professorship with a further € 150,000, so that a total of € 525,100 of state funds is available for the two entities in 2017.
Boris Rhein, Minister for Science and the Arts: “I am very pleased that all the groundwork has now been completed and Professor Steinbacher can start to breathe life into her new task. The Holocaust professorship is a milestone along the path to a better understanding of National Socialist crimes and the history of their impact up to the present day. This joint appointment by Goethe University Frankfurt and the Fritz Bauer Institute will also further enhance the integration of university and institute-based research. I wish Professor Steinbacher every success in her work.”
Professor Steinbacher is a renowned expert in the field of Holocaust research as documented by many pertinent research papers. She already dealt with persecution and extermination policies in the National Socialist state and societal reactions to it in her Master’s thesis at LMU Munich. Her dissertation entitled “‘Model Town’ Auschwitz. Germanisation Policy and Murder of Jews in East Upper Silesia”, which she submitted at Ruhr University Bochum, later formed the basis for an internationally much acclaimed standard reference work on the subject, which was translated into numerous languages.
Professor Birgitta Wolff, President of Goethe University Frankfurt: “It is a great joy to us that we have succeeded in bringing Sybille Steinbacher to Goethe University. A type of Holocaust research such as we see it in Frankfurt can help not only to understand better the genocide of the Jews in the National Socialist era. It is equally important that the right lessons are drawn from it for the present and the future. Sybille Steinbacher’s research is highly topical in view, for example, of the fact that racially and ethnically motivated exclusion and discrimination seem at the moment to becoming socially acceptable again all around the world.”
Professor Sybille Steinbacher, Chair of Research on the History and Impact of the Holocaust and Director of the Fritz Bauer Institute: “The creation of this chair is a special event in the some 20-year history of the Fritz Bauer Institute. It signifies an affirmation and upgrading of its work, which is committed to a dual task: communication and research. Through this chair, research will in future be strengthened and the Institute and Goethe University more closely interlocked. I consider the fact that there is now a professorship in Germany with this special title to be an important achievement in terms of science and research policy. I will be tackling my new tasks with great vigour and creative drive.”
Sybille Steinbacher was already visiting professor at Goethe University Frankfurt for the history and impact of the Holocaust in 2010 in conjunction with the Fritz Bauer Institute, following which she was professor for Comparative Dictatorship, Violence and Genocide Studies at the University of Vienna. She has been Project Manager of the Dachau Symposium on Contemporary History since 2012. She is a member of several scientific bodies, including the international advisory board of the Richard Koebner Minerva Centre for German History at the Hebrew University of Jerusalem.
“The Fritz Bauer Institute is an education and research facility of highest international standing and its outreach goes far beyond the borders of Hesse. Above all the confrontation with the ethical and moral justification structures of the Holocaust up to the present day makes the research so unique and important. Especially in the land of the perpetrators there must be no forgetting. The linking of the new Holocaust professorship with the directorship of the Fritz Bauer Institute is thus a unique opportunity that we are using to give as great a boost as possible to the subject’s scientific reappraisal”, explained Boris Rhein, Minister for Science and the Arts.