Researchers in Frankfurt and Kent identify first step in design of new anti-cancer drugs
New research co-led by the University of Kent has identified a first step in the design of a new generation of anti-cancer drugs that include an agent to inhibit resistance to their effectiveness.
The research by a team led by Professor Martin Michaelis of Kent’s School of Biosciences, in conjunction with Professor Jindrich Cinatl of theGoethe-University, Frankfurt am Main, Germany, could pave the way for tailored combinations of drugs that would provide more effective treatment for patients suffering from therapy-resistant cancers.
Drug resistance is the major reason for the failure of anti-cancer therapies and patient deaths. Despite major improvements in cancer treatment in recent decades, cures are still mostly achieved by early cancer detection and local therapy using surgery and radiotherapy. Once cancer cells have spread throughout the body and formed metastases (secondary tumours), the prognosis remains grim with 5-year survival rates being below 20%.
Effective systemic drug therapies are needed therefore to improve the outcomes of patients diagnosed with metastatic disease. However, many cancers are characterised by intrinsic resistance, where there is no therapy response from the time of diagnosis, or acquired resistance, where there is an initial therapy response but cancer cells eventually become resistant.
Arguably, the most important resistance mechanism in cancer cells is the action of so-called ATP-binding cassette (ABC) transporters, drug pumps that act as a mechanism to move anti-cancer drugs from cancer cells. Of these, ABCB1 (also called multi-drug resistance gene 1 (MDR1) or P-glycoprotein) is the most relevant one. Previous attempts to target ABCB1 as part of anti-cancer therapies have failed.
A major reason for this is that ABCB1 is expressed at many sites in the body, particularly at tissue barriers such as the gastro-intestinal barrier and the blood brain barrier. This has meant in the past that agents that inhibited ABCB1 were not specific to the interaction of the desired anti-cancer drug with the ABCB1 on cancer cells but affected the body distribution of many different drugs and food constituents, resulting in toxic side-effects.
The new research demonstrates that certain inhibitors of ABCB1 specifically interfere with the ABCB1-mediated transport of certain anti-cancer drugs. This provides a first step towards the design of tailored combinations of anti-cancer drugs and ABCB1 inhibitors that specifically cause the accumulation of anti-cancer drugs in ABCB1-expressing cancer cells but do not affect the body distribution of other drugs or food constituents.
In addition to Professor Michaelis and Professor Cinatl and their laboratory members, the team included Dr Mark Wass (University of Kent), Professor Manfred Schubert-Zsilavecz (Goethe-University Frankfurt), Dr Taravat Ghafourian (University of Sussex), and Professor Michael Wiese (University of Bonn) and members of their research groups.
The research, entitled Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport, was published in Oncotarget. See here:
Prof. Dr. Jindrich Cinatl, Institut für Medizinische Virologie, Goethe-Universität Frankfurt; email@example.com; +49 69 6301 6409; Dr. Florian Rothweiler; firstname.lastname@example.org; +49 69 6786 6572.
Lecture in English Language on May 19th 2016
Ludwig Meidner (1884-1966), a leading exponent of German literary and artistic Expressionism, fled from Nazi Germany to London in August 1939, a month prior to the outbreak of war. Six months after his arrival in Britain, he was interned as an “enemy-alien” in Huyton Camp, Liverpool, and thereafter on the Isle of Man. During 1942, shortly after his release from internment, he began working on a cycle of watercolours and drawings »Leiden der Juden in Polen« (Suffering of the Jews in Poland) and, although the series remains largely unpublished and there is a great deal of uncertainty about the quantity, date and sequence of the works, it is clear from their scale and depth of reference that this was intended as a monumental undertaking. Here he re-engaged with political subject matter in responding to reports on the contemporary destruction of Central European Jewry. The lecture at Goethe University's Museum Giersch will explore how, why and through what means Meidner was challenged to respond to the extremely grave news and will deal comparatively with other refugee artists in exile, internment and responses to Holocaust knowledge.
Ludwig Meidner (1884–1966) ranks as one of the outstanding German artists of the modern era. His life and oeuvre exemplify the social fractures which many artists in Germany were confronted with in the first half of the 20th century. The exhibition at Goethe University's Museum Giersch focuses on works created by this Jewish artist throughout his years in exile. To escape Nazi persecution, Meidner emigrated to London in 1939 and lived in England until his return to Germany in 1953. Under extremely difficult circumstances and conditions, Meidner executed an impressive range of works on paper while in exile – sketchbooks, watercolours, charcoal and pencil drawings – works that until now have been overshadowed by his brilliant expressionist oeuvre. The more than 120 works presented in the exhibition will, for the first time, enable this creative period in he artist’s life to receive the wide appreciation it deserves.
The works Meidner created during his exile years represent a highly intense mix of his inner experience and commentary on those times. As such, they are especially relevant today. With great vision, unsparing directness and symbolic condensation, the artist depicts isolation, persecution and annihilation. And it is with empathy, humour and biting satire that he tells us of an absurdly grotesque and abysmal world.
der GOETHE-UNIVERSITÄTSchaumainkai 83 (Museumsufer)
60596 Frankfurt am Main
more information (in German)
What form can professional help take? Field reports from current projects and discussion on interdisciplinary approaches
FRANKFURTThey have experienced terrible things: Bombing raids, death and abuse, an often perilous escape and a not always friendly reception in Germany. Many refugees are traumatised, especially the children. They need professional help. How to approach this is the topic of a conference taking place on 4-6 March at the Bockenheim Campus of Goethe University. The conference is open to teachers and volunteers as well as scientists.
The topic of this international conference is "Migration and trauma – effects on the next generation". The conference is being organised by the Sigmund Freud Institute, Goethe University, the interdisciplinary research centre "Individual Development and Adaptive Education of Children at Risk“ (IDeA) and the University of Stockholm. "Psychoanalysis today and current empirical attachment research have extensive knowledge of both conceptual as well as preventative and therapeutic approaches to dealing with traumatised people", according to the organiser of the conference, Prof. Dr. Marianne Leuzinger-Bohleber, Managing Director of the Sigmund Freud Institute. This knowledge formed the theoretical foundation for five prevention projects, which have been offered since 2010 to over one thousand difficult to reach families with migration backgrounds in precarious social situations. These projects focused on early prevention for so-called "at-risk children".
Many studies show how important it is to provide basic help to traumatised people as quickly as possible, in order to mitigate the long term consequences for them and the following generations. "Traumatisation is the result of experiences which expose people to extreme feelings of despair, powerlessness and helplessness, usually combined with a fear of death. Basic trust is also lost. Those affected can no longer rely on anything; not on one another and not on themselves", Leuzinger-Bohleber explains. "This is why traumatised people are particularly vulnerable to migration experiences and to renewed experiences of passivity and powerlessness in the reception centres." Recent studies show that traumatisation also has a lasting influence on stress regulation, which is explained in several presentations at the conference. This affects early parenthood in particular and hence shapes the next generation as well.
Mitigating the danger of traumatisation through educational, socio-pedagogical and therapeutic support is a pressing humanitarian task for many professions at this time. The work of the different professions is highly interdisciplinary, as reflected by the research performed in this field in Frankfurt. "Our research centre "Individual Development and Adaptive Education of Children at Risk", or IDeA, which in addition to Goethe University also includes the German Institute for International Educational Research and the Sigmund Freud Institute, offers outstanding opportunities in this regard", emphasises Prof. Dr. Sabine Andresen, Professor of Educational Studies at Goethe University.
Discussions at the conference – in German and English – will centre around how the knowledge, which has been and is currently being gained through projects in locations such as Frankfurt, Oslo and Belgrade, can be applied in order to help traumatised children in different educational establishments, from nursery to secondary school. Initial experiences gathered at the refugee clinic at the Sigmund-Freud Institute and the "Michaelis-Dorf" pilot project in a reception centre in Darmstadt will also be presented. This project was started at the end of January and is currently the only one of its kind in Germany. It is managed jointly by the psychoanalyst and professor for Clinical Psychology Marianne Leuzinger-Bohleber and the professor for Educational Sciences Sabine Andresen. In Darmstadt, students, young scientists and volunteers are working side-by-side to support child refugees. Andresen explains: "It is especially important for children and young people to experience the reception centre as a child-friendly place from the start. They want to feel that they are safe there and can contribute their skills. This sort of place has to be created through educational and leisure programmes, opportunities for participation and open-minded adults."
The conference will take place on Friday (March 4th) at 8:15 pm (Campus Bockenheim, Hörsaalgebäude, Hörsaal VI) complemented by a public lecture by Prof. Dr. Vera King, who in March will take the place of Prof. Dr. Rolf Haubl as Acting Director of the Sigmund Freud Institute as well as taking over as Professor of Social Psychology at Goethe University. She will speak about "Transgenerational transmission in the context of adolescence and migration".
This conference continues the tradition of the Joseph Sandler Research Conferences, which have been held in Frankfurt on the first weekend in March for the past eight years. Sandler and his wife opened psychoanalysis up to increased dialogue with the other sciences during the 1990s, and organised this annual conference with that purpose in mind.
Information: Prof. Dr. Marianne Leuzinger-Bohleber, Sigmund Freud Institute, Phone (069) 971204-149; email@example.com, firstname.lastname@example.org; Program at: www.sigmund-freud-institut.de; Registration for the conference: email@example.com, Phone (069) 971204-129
Goethe University is a research-oriented university in the European financial centre Frankfurt In 2014, it celebrates its 100th birthday. Founded in 1914 with purely private funds by liberally-oriented Frankfurt citizens, it is dedicated to research and education under the motto "Science for Society" to this day as a citizens’ university. Many of the early benefactors were Jewish. Over the past 100 years, Goethe University has carried out pioneering work in the social and sociological sciences, economics, chemistry, quantum physics, brain research and labour law. It gained a unique level of autonomy on 1 January 2008 by returning to its historic roots as a "foundation university". Today, it is among the top ten in external funding and among the top three largest universities in Germany, with three clusters of excellence in medicine, life sciences and the humanities. More information at www2.uni-frankfurt.de/gu100
Publisher The President of Goethe University, Frankfurt am Main. Editor Ulrike Jaspers, Consultant for Scientific Communication, Department of Marketing and Communication, Theodor-W.-Adorno-Platz 1, 60323 Frankfurt am Main, Phone: (069) 798-13066, Fax (069) 798-763 12531, firstname.lastname@example.org
Sociologists at Goethe University Frankfurt take a close look at elderly men’s role in childcare.
FRANKFURT. The number of families in which both parents work is increasing. But who looks after the children when the nursery school is closed? Female child minders and surrogate grandmas are very popular, but is childcare an appealing activity for men too? A pre-study at the Department of Sociology is examining the phenomenon of “surrogate granddads”.
A man pushing a pram through the park: 40 years ago this sight would still have turned heads in Germany. This has fundamentally changed, thanks to new gender roles. Today, many men not only play a different part as fathers, but also in their role as grandfathers. But what happens when there is no sign of any grandchildren coming along? For some men, the want to help bring up, play with and spend time with a child, such as was never possible before, might be a reason to act as “surrogate granddad” in another family. But other reasons are also conceivable.
A research project, led by Birgit Blättel-Mink, Professor of Sociology at Goethe University Frankfurt, and Alexandra Rau, Professor of Social Work at Darmstadt University of Applied Sciences, aims to shed light on this to date hardly explored topic. The project is funded by the Hessen State Ministry of Higher Education, Research and the Arts in the framework of its gender research activities. Blättel-Mink is also Director of the Cornelia Goethe Center for Women’s and Gender Studies (CGC) of Goethe University Frankfurt. Sociologist Luigi Wenzl (29) is in charge of the project’s implementation. His theory: The “Surrogate Granddad Phenomenon” could indeed become more widespread in future.
But on what scale does this social phenomenon already occur? Is it above all men who feel that they did not contribute sufficiently to raising their own children? Or do surrogate granddads see it as an opportunity to supplement their pension with a little side job? The topic could thus be relevant for three major sociological debates of the present day: For the debate on the compatibility of family and career and childcare shortfalls in families, for the debate on (re-)activating “younger seniors” for services to society and finally for the debate on precarious employment relationships which do not allow sufficient provision for old age.
Luigi Wenzl has investigated 28 projects which put “honorary” surrogate or voluntary grandparents in touch with families. In the next step, detailed interviews are being held with the surrogate granddads identified and – for the purpose of comparison – with a few surrogate grandmas. “According to our initial assessment, enabling factors are the lack of own grandchildren, an interest in bonding emotionally with a child, the wish to stay young by being in touch with children and at the same time to allow children the experience of being in contact with ‘older’ people”, concludes Wenzl from the first interviews. “But some older people also have the feeling they need to do something to counter ‘modern’ upbringing”, adds Birgit Blättel-Mink, whereby the “surrogate granddads” interviewed wanted to be seen solely as organizers of recreational activities and not as child rearers.
Deviating views on the tasks of a surrogate granddad can, however, lead to difficulties and tension. The study also aims to illuminate how parents and surrogate granddads negotiate their different requirements and opinions. It already became clear to Luigi Wenzl from his first interviews that it is often only through their partners that men are introduced to caring for other people’s children. And some do indeed then shy away from it: In public perception there is still something rather suspicious about older men looking after children.
Luigi Wenzl, Email: email@example.com
“Children's Worlds” study asked eight-year-old children in 16 countries about their well-being for the very first time
FRANKFURT/ZURICH. Over 17,000 eight-year-old children in 16 countries on four continents were asked about their experiences and their views on their lives. No survey of this age group has ever before been undertaken. The second report on the “Children's Worlds” study, which was published recently, reveals important results which can be used to improve children’s lives throughout the whole world. The Jacobs Foundation in Zurich financed the research work on which this report is based and has announced that it will also support the next stage. The new survey of children of between eight and twelve years of age will begin in 2017 and again cover an even larger number of countries.
The views of young children are rarely the subject of research. The “Children’s Worlds” study has closed this gap. The survey asked children about all the important aspects of their lives, including family and home life, friends, money and possessions, school, local environment, time use, personal well-being, view on children’s rights and their general contentment. “This is the first opportunity we have had to compare children’s lives so comprehensively from the perspective of the children themselves”, says Sabine Andresen of Goethe University Frankfurt, one of the principal investigators. “Children perceive the world around them very precisely and we can see who feels compromised in what areas.”
Most of the eight-year-old children in the 16 countries examined were content with their lives and their situation, but there was a minority (about 6% of the children) who reported a lower level of well-being. The percentage of children with a lower sense of well-being varied from under 3% in Colombia and Romania to over 9% in Ethiopia, South Korea and the United Kingdom.
Simon Sommer, Head of Research at the Jacobs Foundation, said: “This project is pioneering. The report concentrates – for the very first time – on the opinions of eight-year-old children with regard to their lives and personal well-being. The Jacobs Foundation will continue to support “Children´s Worlds”, as we are convinced that the study delivers unique and valuable information for everyone who has a special understanding for and an interest in the lives of children and adolescents and who devotes themselves to improving their lives and prospects.”
Most of the children interviewed said that they felt perfectly safe at home, at school and in their local environment. However, 4% of the children reported that they did not feel safe at home, 4% of those interviewed did not feel safe at school and 9% did not agree that they felt safe in their neighbourhood and local environment. Although it might seem at first that these percentages are low, they nevertheless equate to a large group of the youngest schoolchildren whose feeling of safety - of all things - is restricted.
School life – Differences between boys and girls
Most children (62%) said that they liked going to school. This is far higher than amongst the 10-year-old children interviewed (52%) or the 12-year-olds (42%). Going to school becomes less popular with each age group. But the country comparison is revealing too: Children in Algeria and Ethiopia like going to school most, whilst the percentage of children who do not like going to school is comparatively high in Germany, South Korea and the UK. In some countries, including Israel and six European countries, girls have a more positive attitude to school than boys.
Bullying and violence at school
A large number of children (41%) reported that they had been left out by their classmates or hit by other pupils (48%). Such experiences were more frequent amongst eight-year-old children than in the two older groups of participants in the survey. The percentage of children who had experienced violence was highest in Estonia, the UK and Germany, and lowest in South Korea. Feelings of being left out by classmates were highest in the UK and Romania and particularly low in South Korea and Ethiopia.
Knowledge of children’s rights
Almost half the children (46%) stated that they knew about children’s special rights. This was less than amongst the 10 to 12-year-old children interviewed (58 %). Children in Colombia were the best informed about children’s rights (73%). All the same, in Turkey, Ethiopia, Romania and Norway over half the eight-year-old children said that they knew their rights. Professor Asher Ben-Arieh, Study Leader and Co-chairman of the ISCI (International Society for Child Indicators), commented: “This is the first time that we have heard from almost 20,000 eight-year-old children about their activities, feelings and wishes. This remarkable achievement teaches us above all that children know more about their life than anyone else and that all attempts to improve it should always include and take into account their opinions.”
The “Children's Worlds” project will include further countries in its future research work, such as Indonesia, Finland and Italy. The third study will start with the first surveys in September 2017 and the new findings will be published in 2019.
The Children's Worlds Study
Children's Worlds, the International Survey of Children's Well-Being (ISCWeB), is a worldwide research survey on children's subjective well-being. The study aims to collect solid and representative data on children's lives and daily activities, their time use and in particular on their own perceptions and evaluations of their well-being. The purpose is to improve children's well-being by creating awareness among children, their parents and their communities, but also among opinion leaders, decision makers, professionals and the general public.
The current wave of the survey was funded by the Jacobs Foundation. It has so far been completed with over 56,000 children in three age groups (8, 10 and 12 years old) in 17 countries: Algeria, Argentina, Colombia, Estonia, Ethiopia, Germany, Israel, Malta, Nepal, Norway, Poland, Romania, South Africa, South Korea, Spain, Turkey and the UK.
The full report, a summary and supplementary material can be viewed and downloaded at the project website: www.isciweb.org
Media contact for the “Children's World” study in Germany: Professor Dr. Sabine Andresen, Goethe University Frankfurt, S.Andresen@em.uni-frankfurt.de
Media enquiries for the Jacobs Foundation, Zurich: Alexandra Güntzer, firstname.lastname@example.org and for general research questions: Simon Sommer, Head of Research, email@example.com
The Jacobs Foundation is active worldwide in the support of children’s and young people’s development. It was established in 1989 by entrepreneur Klaus J. Jacobs in Zurich, Switzerland. The Jacobs Foundation finances research projects, intervention programmes and scientific institutions with a budget of about 40 million Swiss francs per year. It aims to meet the highest demands in scientific work and provide support for convincing research activities. In the last three years, the Jacobs Foundation has supported the “Children's Worlds” study by providing funding to the amount of € 850.000 and recently announced that it will award a grant of € 250.000 for the third and expanded wave of the study.