New endowed chair for polypharmacy and health services research at Goethe University
FRANKFURT. A third of all patients in general practice suffer from multiple diseases. These patients are usually treated by various medical specialists who often do not adequately coordinate their prescriptions. The mixture of pills may not only have serious side effects; it also strains and unsettles many patients. The appointment of Professor Marjan van den Akker as new “Endowed Chair for Polypharmacy and Health Services Research" at Goethe University's Institute of General Practice should help to improve this situation.
Marjan van den Akker worked at the Maastricht University (Netherlands) and is an internationally recognised expert in the field of multimorbidity and polypharmacy. From 1st March, she will start projects to enhance medication prescriptions to patients with multimorbidity (co-occurring diseases) in cooperation with doctors, pharmacists, scientists and nurse practitioners. The chair has been endowed for a period of six years by INSIGHT Health, a company that specialises in the analysis of medical prescriptions.
“Older patients in particular, but younger patients as well, are affected by multimorbidity. They usually have a complex health situation that can be quite challenging for doctors," says Professor van den Akker. Her research focuses on frequent disease combinations and their medical treatment. She wants to improve the care for these patients by the further development and evaluation of interventions.
Previous studies have shown that for many patients with multimorbidity, overall prescriptions can be improved either by reducing medications, or sometimes by prescribing additional medication. “It's important to me to take the preferences and living circumstances of the patients into account. The benefits and risks of medication need to be discussed with their doctor, and a decision then reached together."
In view of the frequency and complexity of polypharmacy, Professor van den Akker desires to educate both medical and pharmaceutical students in caring for this patient group. She plans to set up an interdisciplinary teaching programme offering joint classes for future doctors and future pharmacists.
Prof. Ferdinand Gerlach, Director of the Institute of General Practice, is happy with the new chair. “The new endowed chair is a perfect fit for our research profile in Frankfurt. With Professor van Akker, we can develop new paths for improving health care for the chronically ill and support general practitioners in their important work even better."
Professor Pfeilschifter, Dean of the Faculty of Medicine, adds: “Medication research and medication therapy are a focal point of the Faculty of Medicine and of Goethe University overall. As such Professor van den Akker is an excellent choice and she complements the dynamic field of Medicine at Goethe University."
Further information: Prof. Dr. Marjan van den Akker, Institute of General Practice, Campus Niederrad, Tel.: +49 69 6301-80454/-5930; m.vandenAkker@allgemeinmedizin.uni-frankfurt.de
German-Israeli conference discusses the work of the Frankfurt philosopher Franz Rosenzweig
Franz Louis August Rosenzweig, born in Kassel in 1886, was the only child of a Jewish industrialist and city politician and his wife. He began studying medicine in 1905, before switching to a study of history and philosophy. His dissertation represents the first comprehensive critical analysis of Hegel's political philosophy. In 1913, Rosenzweig grappled intensively with the question of whether to convert to Christianity, but decided against it in the end and dedicated himself to a concentrated study of Judaism. During World War I, he volunteered for medical service and was later with the artillery at the front in the Balkans – a formative experience. After the war, Rosenzweig turned his back on his historical studies and dedicated himself completely to establishing the House of Jewish Learning in Frankfurt am Main, whose goal was to demonstrate ways of Jewish life in the modern world. Rosenzweig's book “Star of Redemption" was published in 1921. Already plagued by serious illness, Rosenzweig began a translation of the Jewish scriptures together with Martin Buber – a work whose expressive language remains fascinating to this day. Franz Rosenzweig died when he was only 43 years old in 1926.
“The Star of Redemption“ is considered a fundamental work of Jewish thinking in the 20th Century. The conference, organized by the Martin-Buber Chair for Jewish Thought and Philosophy along with the International Rosenzweig Society e.V. and the Franz Rosenzweig Minerva Research Center at the Hebrew University of Jerusalem, will discuss “redemption" in light of Rosenzweig's work. Approximately 100 researchers in history, philosophy and political science from Europe, Asia, North and Latin America will meet in Jerusalem to discuss the “Star"'s central concept of redemption and its significance for understand Judaism as well as its general relevance today. In addition to the historical, theological and historical-philosophical aspects, the interreligious dimension of the question of redemption in Judaism, Christianity and Islam will play a central role.
The lectures will not only concern themselves with the reconstruction and interpretation of Rosenzweig's concepts, but also with the question of how Rosenzweig's ideas have affected other philosophies and theologies, the relationship between messianism and politics, individual and collective redemption, and also with aesthetic aspects – for example in music. “What makes this conference unique is that world's need for redemption, which in addition to the Jewish perspective is relevant for Christian, Muslim and secular viewpoints, can be reflected in all its diversity in the mirror of Rosenzweig's thought," says Christian Wiese, who currently holds the Martin Buber Chair for Jewish Thought and Religion, and is deputy chair of the International Rosenzweig Society.
The conference continues a longstanding, fruitful collaboration between the Martin Buber Chair and Franz Rosenzweig Minerva Research Center, a collaboration that is of great importance within the humanities. “The importance of the heritage of the early 20th Century German-Jewish culture as embodied by Rosenzweig being publically remembered in today's Israel as a product close German-Israeli cooperation can hardly be exaggerated," says Wiese. Equally significant is the symbolic importance of Jerusalem as event location. More than anyone else in the pre-Nazi era, Rosenzweig reflected on the relationship between German and Jewish culture, between Judaism and Christianity, and the tensions of a Jewish identity caught between exile and nation. To discuss the impulses of his thought in Jerusalem today is decisive with regard to the current Christian-Jewish and German-Israel dialogue.
The strong interest from a younger generation of researchers makes clear that Rosenzweig's thinking is still relevant: a workshop for early-career researchers in Jewish religious philosophy financed by the Minerva Foundation is incorporated in the conference, and the speakers also largely belong to the younger international generation in this field of research, including several doctoral candidates and postdocs from Goethe University. Never have so many doctoral candidates and young postdocs actively taken part in a Rosenzweig conference: in total, 18 doctoral candidates and at least 22 postdocs will present research results in Jerusalem.
The conference is also part of a more extensive research strategy focusing on Martin Buber and Franz Rosenzweig. The Martin Buber Chair and Franz Rosenzweig Minerva Center will also organize a joint conference on Buber's political thought to commemorate the 30-year anniversary of the Buber Chair.
Further Information: Professor Christian Wiese, Martin-Buber Chair for Jewish Thought and Philosophy, E-Mail: email@example.com
The programme can be found at this link. ttps://www.uni-frankfurt.de/76297689/buber_Rosenzweig_programm.pdf
Males are extremely faithful to their mates
FRANKFURT. Amphipods of the species Gammarus roeselii guard their chosen mates, often carrying them with them for days and defending them against potential rivals. This behaviour requires a lot of time and energy, so that the males make their choice with care. Scientists at Goethe University have now investigated under which circumstances males are prepared to revise their decision.
In their study, Carolin Sommer-Trembo, Konrad Lipkowski and their two colleagues compare the behaviour of Gammarus males from two populations with very different densities. They collected test animals from two neighbouring areas and let them acclimate for a few days in large aquariums. During this time, pairs formed, with the males firmly grasping the female and not letting her go before fertilization (amplectant pair).
In the next step, the amplectant pairs were carefully separated from one another, and each male was offered another (morphologically similar) female, one they had not previously selected of their own accord. The males from the populations with a very low density grasped the female within a short period. As expected, they were not particularly choosy, since they seldom encountered females in their natural environment and therefore had to seize the opportunity immediately.
The males from the population consisting of many individuals spent a significantly longer period searching through their small test basin for an alternative (hopefully better) female, before accepting the female selected by the researchers. “Often, an amplectant pair didn't even come about," Carolin Sommer reports. “If, after separation, we returned the female the male itself had selected, the male accepted it just as quickly as the males from the other population accepted a new female."
The amphipods, which are only millimetres-long, are therefore definitely choosy, with the degree of choosiness depending on the population density in their natural environments. “The population density has enormous influence on whether the male can afford to take a closer look at his mate," concludes Konrad Lipkowski.
Publication: Lipkowski K, Plath M, Klaus S, Sommer-Trembo C. Population density affects male mate choosiness and morphology in the mate-guarding amphipod Gammarus roeselii (Crustacea: Amphipoda). Biological Journal of the Linnéan Society, https://dx.doi.org/10.1093/biolinnean/bly201
An image may be downloaded at: www.uni-frankfurt.de/76164186
Caption: The male amphipod (above) latches onto the smaller female (below) for up to several days and defends her against rivals. The picture shows an amplectant pair belonging to the species Gammarus sp. Credit: Konrad Lipkowski
Konrad Lipkowski, Institute for Ecology, Evolution and Diversity, Faculty of Biosciences, Riedberg Campus, Tel.: +49 (69) 798- 42211, firstname.lastname@example.org.
Dr. Carolin Sommer-Trembo, Zoological Institute, University of Basel, +41 (0) 61 207 59 05, email@example.com
For science, or for life?
FRANKFURT. Should regulations for environmental protection be valid beyond our solar system? Currently, extra-terrestrial forms of life are only deemed worth protecting if they can be scientifically investigated. But what about the numerous, presumably lifeless planets whose oxygen atmospheres open up the possibility of their settlement by terrestrial life forms? Theoretical physicist Claudius Gros from Goethe University has taken a closer look at this issue.
On earth, environmental protection has the primary goal of ensuring the availability of clean water and clean air for human beings in the future. Human interests usually take also precedent when it comes to protecting more developed animals and plants. Lower life forms such as bacteria, on the other hand, are considered worthy of protection only in exceptional cases.
Claudius Gros, professor for theoretical physics at Goethe University, has now investigated the degree to which the norms for the protection of planets can be derived analogously from issues that arise in environmental protection on Earth. The international COSPAR agreements on space research stipulate that space missions must ensure that any existing life – such as possibly on the Jupiter moon Europa – or traces of previous life forms – perhaps on Mars – are not polluted, so that they remain intact for scientific purposes. The protection of extra-terrestrial life as valuable in and of itself is not stipulated.
The COSPAR Guidelines apply to our solar system. But to which extent should they be applied to planetary systems beyond our solar system (exoplanets)? This will become a relevant issue with the advent of launch pads for miniature interstellar space probes, such as of the type in development by the “Breakthrough Starshot" initiative. Gros argues that the protection of exoplanets for the use of humankind could not be justified. Apart from fly-bys, we could carry out scientific studies only with space probes able to slow down in an alien solar system. Using the best technology available today, this would require magnetic sails and missions lasting thousands of years, at the least.
According to Gros, the protection of exoplanets would also be irrelevant if these planets were lifeless, even if they were otherwise habitable. This probably includes planet systems such as the Trappist-1 system, whose central star is an M-dwarf star. Planets orbiting in the habitable zone of an M-dwarf star have a dense oxygen atmosphere that was formed through physical processes before cooling. Whether life can develop on such planets is questionable. Free oxygen acts corrosively on prebiotic reaction cycles, which are considered prerequisites for the origin of life. “Whether there is another way for life to form on these oxygen planets is an open question at this time," says Gros. “If not, we would find ourselves living in a universe in which most of the habitable planets are lifeless, and thus suitable for settlement by terrestrial life forms," he adds.
Publications: Claudius Gros: Why planetary and exoplanetary protection differ: The case of long duration Genesis missions to habitable but sterile M-dwarf oxygen planets, Acta Astronautica 2019, in press. https://arxiv.org/abs/1901.02286
Claudius Gros: Developing Ecospheres on Transiently Habitable Planets: The Genesis Project, Astrophysics and Space Science 361, 324 (2016) http://link.springer.com/article/10.1007/s10509-016-2911-0
Together with Russian researchers, archaeologists from the universities of Frankfurt and Mainz are studying Bronze Age activity in the steppe between Europe and Asia
FRANKFURT. Archaeologists from Goethe University will be returning to the Urals for further research work. In collaboration with researchers from Johannes Gutenberg University Mainz and Russian colleagues, they want to find out what could have led to major transformations in the way of life there in the second millennium BC. The project has been awarded funds of € 600,000 by the German Research Foundation, initially up until the end of 2020. The research work follows on from an earlier project undertaken between 2009 and 2014.
The aim of the project is to reconstruct demographic processes and settlement structures in the late Bronze Age up to the transition to the Iron Age – what is known as the post-Sintashta-Petrovka period. Artefacts discovered so far have shown that the southern Trans-Ural region at the dividing line between Europe and Asia on the northern edge of the Eurasian Steppe constitutes a unique cultural landscape. Superb Bronze and Iron Age monuments, such as burial mounds (“kurgans") and settlements, show that this was a centre of economic development and sociocultural processes that already began in the third millennium BC. After the decline of fortified settlements, the housing structure changed and “open" settlements with terraced houses without fortifications emerged. Russian research dates these settlements to the middle of the second millennium BC, i.e. the Late Bronze Age.
During the research phase that lasted from 2008 to 2014, Professor Rüdiger Krause devoted himself above all to the fortified settlements of the Sintashta-Petrovka period (around 2000 BC). Characteristic for this culture were early chariots, intensive copper mining and substantial bronze production. Attention has now shifted to various other archaeological sites of the Bronze and Iron Ages in the microregion at the confluence of the Yandyrka and Akmulla rivers and the upper end of the Karagaily-Ayat valley. How have settlement structures evolved? How was the landscape used as the economic foundation for livestock farming? And how have funeral customs changed? The intention is to study the demographic processes underlying all this in the course of the project, using not only palaeogenetic techniques but also archaeological excavations, geophysical surveys, interpretation of the material culture and archaeobotany.
Who were the people responsible for the shift at that time from a settled form of existence to a nomadic way of life? Where did they originate from and how did they come to arrive in the Urals? Archaeology and palaeogenetics will work hand in hand in the search for answers to these questions. One of the aims of this collaboration is to analyse population genetics using state-of-the-art genome analysis methods.
The team led by Professor Joachim Burger at the University of Mainz is specialised in the analysis of genomes from archaeological skeletons. In the framework of this project, the palaeogenetics experts from Mainz will examine the question of to what extent genetic influences from Europe or the central Asian steppe coincide with the cultural transformation to be observed in the Trans-Ural region. Was it foreigners who introduced the change? Or did regional cultural developments take place here? How have demography and population structure changed over the millennia? To find answers to these questions, the researchers from Mainz will use high-resolution sequencing to study the genomes from the project's archaeological sites and analyse them with statistical methods they have developed themselves, in order to unearth as much detailed information as possible about the people of the Bronze and Iron Ages.
A report on the first phase of the research project can be read (in German) in Forschung Frankfurt, 1.2012, pp. 32-36: “Innovationwen vor 4000 Jahren in der Eurasischen Steppe. Streitwagenfahrer und Metallurgen in befestigten Siedlungen“ by R. Krause and J. Fornasier.
Further information: Professor Rüdiger Krause, Institute of Archaeological Sciences, Prehistory and Early History, Westend Campus, Norbert-Wollheim-Platz 1, Tel.: +49(0)69-798-32120; https://www.uni-frankfurt.de/61564916/LOEWE-Schwerpunkt
Professor Joachim Burger, Palaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, Anselm-Franz-von-Bentzel-Weg 7, 55128 Mainz, Tel.: +49(0)6131-39-20981; http://palaeogenetics-mainz.de
Image material can be downloaded from: http://www.uni-frankfurt.de/75784479
Captions: 01 Trans-Ural region. Konopljanka-2 Bronze Age terraced house settlement with a filled-in well shaft in the foreground. 2018 excavation. © Ural Project, Goethe University
02 Trans-Ural region, Neplujevka. Burial of an adult in a large kurgan. Late Bronze Age, 2017 excavation. © Ural Project, Goethe University
03 Trans-Ural region, Neplujevka. Burial of a young person in a large kurgan. Late Bronze Age, 2016 excavation. © Ural Project, Goethe University
04 University of Mainz, documentation of bone samples in the cleanroom laboratory in preparation of palaeogenetic tests. © Joachim Burger, JGU Mainz
05 University of Mainz, preparation of bone samples in the cleanroom laboratory for genome analysis. © Joachim Burger, JGU Mainz