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Two research aircraft investigate reduced concentrations of pollutants in the air
FRANKFURT. The COVID-19 pandemic is not only
affecting almost every aspect of our daily lives, but also the environment. A
German team including atmosphere researchers around Prof. Joachim Curtius
(Goethe University Frankfurt) now wants to find out how strong these effects
are on the atmosphere. Over the next two weeks, as part of the BLUESKY research
programme, the scientists led by the Max Planck Institute for Chemistry and the
German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt; DLR) will measure
concentrations of trace gases and pollutants in the air over European urban
areas and in the flight corridor to North America. The aim of these research
missions is to investigate how reduced emissions from industry and transport
are changing atmospheric chemistry and physics.
A German research team now wants to make
rapid use of this unusual situation for the BLUESKY project. Scientists from
DLR, the Max Planck Institute for Chemistry, Goethe University Frankfurt, and
the research centres at Jülich and Karlsruhe intend to use two DLR research
aircraft to conduct a globally unique investigation into the resulting changes
in Earth's atmosphere for the first time. DLR’s HALO and Falcon research
aircraft have been equipped with highly specialised instrumentation and will
fly over Germany, Italy, France, Great Britain and Ireland in the course of the
next two weeks. They will also fly over the North Atlantic, along the flight
corridor to North America.
“DLR is deploying part of its unique
research aircraft fleet to exploit an almost unique opportunity. During these
missions, the atmosphere will be analysed in a state that could be achieved in
the future with sustainable management of human activities. We will observe how
the environment changes with the ramp-up of industrial activities. This will
give us an entirely new perspective on the anthropogenic influence on Earth’s
atmosphere,” explains Rolf Henke, DLR Executive Board Member responsible for
aeronautics research. “Together with our partners, we are making a significant
contribution to redefining humankind’s activities once the pandemic is under
control.”
Coordinated research flights with two measurement
aircraft
Jos Lelieveld, Director of the Max Planck Institute
for Chemistry, wants to use the BLUESKY missions to clarify whether there is a
correlation between the clear blue sky during the lockdown and the prevalence
of aerosol particles in the atmosphere. “The unique blue sky of recent weeks
cannot be explained by meteorological conditions and the decrease in emissions
near the ground. Aircraft may have a greater impact on the formation of aerosol
particles than previously thought,” says the atmospheric researcher, who is the
Scientific Director of the HALO flights. Aerosols, microscopic particles in the
air that also influence cloud formation, are finely distributed. They scatter
and absorb solar radiation and thus also have an impact on the climate, because
they influence the radiation balance of the atmosphere. Aerosols are created,
amongst other ways, during the combustion of fossil fuels.
Christiane Voigt, Head of the Cloud
Physics Department at the DLR Institute of Atmospheric Physics and Scientific
Director of the Falcon flights, also sees a unique opportunity with BLUESKY.
“The current state of the atmosphere represents a kind of ‘zero point’ for
science. We will be able to measure a reference atmosphere that is only
slightly polluted with emissions from industry and transport, including
aviation. This gives us a unique opportunity to better understand the effects
of the anthropogenic emissions prior to the shutdown.” The atmospheric
physicist emphasises that, only through the cooperation of all the partners,
was it possible to plan and implement the scientifically and logistically
highly complex missions at very short notice.
Emissions from air transport, industry and road
traffic in urban areas
Voigt and her colleagues believe that the
BLUESKY data will provide a clearer picture of anthropogenic influences on the
composition of Earth’s atmosphere. With the equipment on board both research
aircraft, the BLUESKY scientists are investigating aircraft emissions such as
nitrogen oxides, sulphur dioxide and aerosols at cruising altitude, in addition
to the few remaining contrails. Among other things, they want to find out how
much these emissions have decreased over Europe and the North Atlantic flight
corridor. Approximately 30,000 aircraft fly over Europe every day, with
correspondingly significant emissions. The reduced air traffic will allow more
flexible flight routes for the measurements.
In addition, the researchers want to
investigate the reduced emission plumes from urban areas and clarify how
emissions are distributed at the atmospheric boundary layer. For example, the
BLUESKY scientists plan to fly over the Ruhr area and the regions around
Frankfurt am Main, Berlin and Munich. Flights over the Po Valley in Italy and
around Paris and London are also planned. “Close to cities and conurbations, we
will approach the atmospheric boundary layer at an altitude of one to two
kilometres, since emissions from road traffic and industry are concentrated
there,” explains Jos Lelieveld. “We are interested in how much the
concentrations of sulphur dioxide, nitrogen oxides, hydrocarbons and their
chemical reaction products, as well as ozone and aerosols, have changed.” He is
also very proud that the team is the first in the world to implement a
measurement campaign of this type.
Rapid preparations for flights – with special
infection control rules
In recent weeks, two DLR research aircraft
–measuring the Falcon 20E and the Gulfstream G550 HALO – have been successfully
converted at short notice for the BLUESKY missions. The conversions were
carried out at the DLR Flight Operations Facility in Oberpfaffenhofen.
“Numerous instruments have had to be installed and adapted, and the aircraft
modified for the upcoming missions,” says Burkard Wigger, Head of DLR Flight
Experiments. “Close cooperation between the various scientific organisations
has made it possible for these two research aircraft to operate simultaneously
under the challenging conditions resulting from the Coronavirus pandemic.”
The preparation, execution and follow-up
of the flights is being carried out in accordance with the current rules
regarding personal interactions and infection control. Joint flights by Falcon
and HALO are planned until the first half of June. The evaluation of the data
and the analysis of the results will then take several months. The analysis
will include comparative data from previous HALO research flight campaigns on
air traffic emissions and emissions from major cities and conurbations.
About HALO: The High Altitude and Long Range (HALO) research aircraft is a joint initiative of German environmental and climate research institutions. HALO is supported by grants from the Federal Ministry of Education and Research (BMBF), the German Research Foundation (DFG), the Helmholtz Association of German Research Centres, the Max Planck Society (MPG), the Leibniz Association, the Free State of Bavaria, the Karlsruhe Institute of Technology (KIT), the Forschungszentrum Jülich and the German Aerospace Center (DLR).
More information: Prof. Joachim Curtius, Institute for Atmospheric and Environmental Sciences, Goethe University Frankfurt, Phone: +49 (0)69 798-40258, curtius@iau.uni-frankfurt.de
International research project observes ultrafast particle growth through ammonia and nitric acid
FRANKFURT. When winter smog takes over Asian
mega-cities, more particulate matter is measured in the streets than expected.
An international team, including researchers from Goethe University Frankfurt,
as well as the universities in Vienna and Innsbruck, has now discovered that
nitric acid and ammonia in particular contribute to the formation of additional
particulate matter. Nitric acid and ammonia arise in city centres predominantly
from car exhaust. Experiments show that the high local concentration of the vapours
in narrow and enclosed city streets accelerates the growth of tiny nanoparticles
into stabile aerosol particles (Nature, DOI 10.1038/s41586-020-2270-4).
In crowded urban centres, high concentrations of particulate matter cause considerable health effects. Especially in winter months, the situation in many Asian mega-cities is dramatic when smog significantly reduces visibility and breathing becomes difficult.
Particulates, with a diameter of less than
2.5 micrometres, mostly form directly through combustion processes, for example
in cars or heaters. These are called primary particulates. Particulates also
form in the air as secondary particulates, when gases from organic substances,
sulphuric acid, nitric acid or ammonia, condense on tiny nanoparticles. These grow
into particles that make up a part of particulate matter.
Until now, how secondary particulates
could be newly formed in the narrow streets of mega-cities was a puzzle.
According to calculations, the tiny nanoparticles should accumulate on the abundantly
available larger particles rather than forming new particulates.
Scientists in the international research
project CLOUD have now recreated the conditions that prevail in the streets of
mega-cities in a climate chamber at the particle accelerator CERN in Geneva,
and reconstructed the formation of secondary particulates: in the narrow and
enclosed streets of a city, a local increase of pollutants occurs. The cause of
the irregular distribution of the pollutants is due in part to the high pollutant
emissions at the street level. Furthermore, it takes a while before the
street air mixes with the surrounding air. This leads to the two pollutants
ammonia and nitric acid being temporarily concentrated in the street air. As the
CLOUD experiments demonstrate, this high concentration creates conditions in
which the two pollutants can condense onto nanoparticles: ammonium nitrate
forms on condensation cores the size of only a few nanometres, causing these
particles to grow rapidly.
“We have observed that these nanoparticles
grow rapidly within just a few minutes. Some of them grow one hundred times
more quickly than we had previously ever seen with other pollutants, such as
sulphuric acid," explains climate researcher Professor Joachim Curtius from
Goethe University Frankfurt. “In crowded urban centres, the process we observed
therefore makes an important contribution to the formation of particulate
matter in winter smog – because this process only takes place at temperatures
below about 5 degrees Celsius." The aerosol physicist Paul Winkler from the
University of Vienna adds: “When conditions are warmer, the particles are too
volatile to contribute to growth."
The formation of aerosol particles from
ammonia and nitric acid probably takes place not only in cities and crowded
areas, but on occasion also in higher atmospheric altitudes. Ammonia, which is primarily
emitted from animal husbandry and other agriculture, arrives in the upper
troposphere from air parcels rising from close to the ground by deep convection,
and lightning creates nitric acid out of nitrogen in the air. “At the
prevailing low temperatures there, new ammonium nitrate particles are formed
which as condensation seeds play a role in cloud formation," explains ion physicist
Armin Hansel from the University of Innsbruck, pointing out the relevance of
the research findings for climate.
The experiment CLOUD (Cosmics Leaving
OUtdoor Droplets) at CERN studies how new aerosol particles are formed in the atmosphere
out of precursor gases and continue to grow into condensation seeds. CLOUD
thereby provides fundamental understanding on the formation of clouds and
particulate matter. CLOUD is carried out by an international consortium
consisting of 21 institutions. The CLOUD measuring chamber was developed with
CERN know-how and achieves very precisely defined measuring conditions. CLOUD experiments
use a variety of different measuring instruments to characterise the physical
and chemical conditions of the atmosphere consisting of particles and gases. In
the CLOUD project, the team led by Joachim Curtius from the Institute for
Atmosphere and Environment at Goethe University Frankfurt develops and operates
two mass spectrometers to detect trace gases such as ammonia and sulphuric acid
even at the smallest concentrations as part of projects funded by the BMBF and
the EU. At the Faculty of Physics at the University of Vienna, the team led by
Paul Winkler is developing a new particle measuring device as part of an ERC
project. The device will enable the quantitative investigation of aerosol dynamics
specifically in the relevant size range of 1 to 10 nanometres. Armin Hansel
from the Institute for Ion Physics and Applied Physics at the University of Innsbruck
developed a new measuring procedure (PTR3-TOF-MS) to enable an even more
sensitive analysis of trace gases in the CLOUD experiment with his research
team as part of an FFG project.
Publication:
Wang, M., Kong, W., et al. Rapid growth of
new atmospheric particles by nitric acid and ammonia condensation. Nature, DOI
10.1038/s41586-020-2270-4.
Further information: Prof. Dr. Joachim Curtius, Institute for Atmosphere and Environment, Goethe University Frankfurt am Main, Tel: +49 69 798-40258, email: curtius@iau.uni-frankfurt.de
Prof. Dr. Armin Hansel, Institute for Ion Physics and Applied Physics, University of Innsbruck, Tel.: +43 512 507 52640, email: armin.hansel@uibk.ac.at
Prof. Dr. Paul Winkler, Aerosol physics and Environmental Physics, Faculty for Physics, University of Vienna, Tel: +43-1-4277-734 03, email: paul.winkler@univie.ac.at
Cell culture model: several compounds stop SARS-CoV-2 virus
FRANKFURT. A team of biochemists and virologists at
Goethe University and the Frankfurt University Hospital were able to observe how
human cells change upon infection with SARS-CoV-2, the virus causing COVID-19
in people. The scientists tested a series of compounds in laboratory models and
found some which slowed down or stopped virus reproduction. These results now
enable the search for an active substance to be narrowed down to a small number
of already approved drugs. (Nature DOI: 10.1038/s41586-020-2332-7).
Based on these findings, a US company reports that it is preparing clinical
trials. A Canadian company is also starting a clinical study
with a different substance.
Since the start of February, the Medical Virology of the Frankfurt University Hospital has been in possession of a SARS-CoV-2 infection cell culture system. The Frankfurt scientists in Professor Sandra Ciesek's team succeeded in cultivating the virus in colon cells from swabs taken from two infected individuals returning from Wuhan (Hoehl et al. NEJM 2020).
Using a technique developed at the
Institute for Biochemistry II at Goethe University Frankfurt, researchers from
both institutions were together able to show how a SARS-CoV-2 infection changes
the human host cells. The scientists used a particular form of mass
spectrometry called the mePROD method, which they had developed only a few
months previously. This method makes it possible to determine the amount and
synthesis rate of thousands of proteins within a cell.
The findings paint a picture of the
progression of a SARS-CoV-2 infection: whilst many viruses shut down the host's
protein production to the benefit of viral proteins, SARS-CoV-2 only slightly
influences the protein production of the host cell, with the viral proteins
appearing to be produced in competition to host cell proteins. Instead, a SARS-CoV-2
infection leads to an increased protein synthesis machinery in the cell. The researchers
suspected this was a weak spot of the virus and were indeed able to
significantly reduce virus reproduction using something known as translation
inhibitors, which shut down protein production.
Twenty-four hours after infection, the
virus causes distinct changes to the composition of the host proteome: while
cholesterol metabolism is reduced, activities in carbohydrate metabolism and in
modification of RNA as protein precursors increase. In line with this, the
scientists were successful in stopping virus reproduction in cultivated cells by
applying inhibitors of these processes. Similar success was achieved by using a
substance that inhibits the production of building blocks for the viral genome.
The findings have already created a stir on
the other side of the Atlantic: in keeping with common practise since the
beginning of the corona crisis, the Frankfurt researchers made these findings
immediately available on a preprint server and on the website of the Institute
for Biochemistry II (http://pqc.biochem2.de#coronavirus). Professor Ivan Dikic, Director of the
Institute, comments: “Both the culture of 'open science', in which we share our
scientific findings as quickly as possible, and the interdisciplinary collaboration
between biochemists and virologists contributed to this success. This project started
not even three months ago, and has already revealed new therapeutic approaches
to COVID-19."
Professor Sandra Ciesek, Director of the
Institute for Medical Virology at the University Hospital Frankfurt, explains:
“In a unique situation like this we also have to take new paths in research. An
already existing cooperation between the Cinatl and Münch laboratories made it
possible to quickly focus the research on SARS-CoV-2. The findings so far are a
wonderful affirmation of this approach of cross-disciplinary collaborations."
Among the substances that stopped viral
reproduction in the cell culture system was 2-Deoxy-D-Glucose (2-DG), which interferes
directly with the carbohydrate metabolism necessary for viral reproduction. The
US company Moleculin Biotech possesses a substance called WP1122, a prodrug
similar to 2-DG. Recently, Moleculin Biotech announced that they are preparing
a clinical trial with this substance based on the results from Frankfurt. https://www.moleculin.com/covid-19/.
Based on another one of the substances
tested in Frankfurt, Ribavirin, the Canadian company Bausch Health Americas is
starting a clinical study with 50 participants: https://clinicaltrials.gov/ct2/show/NCT04356677?term=04356677&draw=2&rank=1
Dr Christian Münch, Head of the Protein
Quality Control Group at the Institute for Biochemistry II and lead author, comments:
“Thanks to the mePROD-technology we developed, we were for the first time able
to trace the cellular changes upon infection over time and with high detail in
our laboratory. We were obviously aware of the potential scope of our findings.
However, they are based on a cell culture system and require further testing. The
fact that our findings may now immediately trigger further in vivo
studies with the purpose of drug development is definitely a great stroke of
luck." Beyond this, there are also other potentially interesting candidates
among the inhibitors tested, says Münch, some of which have already been
approved for other indications.
Professor Jindrich Cinatl from the
Institute of Medical Virology and lead author explains: “The successful use of
substances that are components of already approved drugs to combat SARS-CoV-2 is
a great opportunity in the fight against the virus. These substances are
already well characterised, and we know how they are tolerated by patients.
This is why there is currently a global search for these types of substances.
In the race against time, our work can now make an important contribution as to
which directions promise the fastest success."
Publication:
SARS-CoV-2 infected host cell proteomics
reveal potential therapy targets. Denisa Bojkova, Kevin Klann, Benjamin Koch,
Marek Widera, David Krause, Sandra Ciesek, Jindrich Cinatl, Christian Münch. Nature DOI: 10.1038/s41586-020-2332-7,
https://www.nature.com/articles/s41586-020-2332-7 (active starting 10am London time (BST), 5am US Eastern Time)
Images
may be
downloaded here: http://www.uni-frankfurt.de/88340061
Captions:
Dr. Christian Münch (Credit: Uwe Dettmar
for Goethe University Frankfurt)
Prof. Dr. rer. nat. Jindrich Cinatl (Credit:
University Hospital Frankfurt)
More
about the mePROD method: Biochemistry researchers at Goethe
University develop a new proteomics procedure https://aktuelles.uni-frankfurt.de/englisch/biochemistry-researchers-at-goethe-university-develop-new-protoeomics-procedure/
Further information:
Professor Dr. rer. nat. Jindrich Cinatl, Head of the Research Group Cinatl, Institute for Medical Virology, University Hospital Frankfurt am Main, Tel.
+49 69 6301-6409, E-mail: cinatl@em.uni-frankfurt.de,
Homepage: https://www.kgu.de/einrichtungen/institute/zentrum-der-hygiene/medizinische-virologie/forschung/research-group-cinatl/
Dr.
Christian Münch, Head of the Group Protein Quality Control, Institute for Biochemistry II, Goethe University Frankfurt am Main Tel: +49 69 6301 6599, E-Mail: ch.muench@em.uni-frankfurt.de,
Homepage:
https://www.biochem2.com/index.php/22-ibcii/pqc/130-frontpage-pqc
Heat-loving bacteria use various tiny surface hairs for movement and DNA reception
FRANKFURT. Bacteria of
the species Thermus thermophilus possess
two types of extensions on their surface (pili) for the purpose of motion and for
capturing and absorbing DNA from their environment. This has been discovered by
researchers at Goethe University together with researchers in Great Britain.
The discovery of the motion pilus helps to better understand the functionality
of the DNA-capturing pilus functions. (Nature Communications, DOI 10.1038/s41467-020-15650-w)
The bacteria Thermus thermophilus likes it hot. It was first discovered in the hot springs at Izu in Japan, where it thrives at an optimal temperature of about 65 degrees Celsius. Like all bacteria, Thermus thermophilus has developed mechanisms to adjust to changing environmental conditions. The bacteria changes its genetic material by exchanging DNA with other bacteria, or absorbing DNA fragments from its environment. These might come from dead bacteria cells, plants or animals. The bacteria incorporate the DNA fragments into their genetic material and keep it if the DNA proves useful.
Microbiologists at Goethe University led
by Professor Beate Averhoff from the Molecular Microbiology & Bioenergetics
of the Department of Molecular Biosciences together with a team of scientists
led by Dr Vicky Gold from the “Living Systems" Institute of the University of
Exeter in Great Britain have now studied the tiny hairs (called pili) on the
surface of the Thermus bacteria. The
scientists discovered that there are two types of pili with different
functions. High-resolution electron microscope images from Great Britain allow
thick and thin pili to be distinguished, and the Frankfurt scientists used
biochemical and molecular biological methods to demonstrate that the thick pili
are for DNA capture, and the thin pili for moving on surfaces.
“We want to find out exactly how Thermus thermophilus absorbs DNA from
its environment using its pili, as the precise mechanism is unknown," explains
Professor Beate Averhoff from the Institute for Molecular Biosciences at Goethe
University. “Through our most recent investigations we have learned that Thermus bacteria have distinct pili for
motion. Therefore, the thick pili possibly serve the purpose of DNA absorption,
which demonstrates how important this process is for the bacteria. In our
structure analyses we also found an area on the thick pili where DNA could bind."
The interplay of electron microscopy and
molecular biology also allowed the scientists to better understand the
mechanics of the pili. For both motion and DNA absorption, pili have to be
dynamic, i.e., able to be extended and retracted. “For the first time, the high
resolution structure of both pili gave us insights not only into the structure
of the pili, but also into the dynamics," Averhoff explains.
Since pili are widespread and in
pathogenic bacteria are also responsible for attaching to the host, this may
lead to new points of attack for preventing infectious processes.
Publication:
Alexander Neuhaus, Muniyandi Selvaraj, Ralf Salzer,
Julian D. Langer, Kerstin Kruse, Lennart Kirchner, Kelly Sanders, Bertram Daum,
Beate Averhoff, Vicki A. M. Gold (2020). Cryo-electron microscopy reveals two
distinct type-IV pili assembled by the same bacterium. Nature Communications, https://doi.org/10.1038/s41467-020-15650-w )
An
image may be downloaded here: http://www.uni-frankfurt.de/88063448
Caption:
Bacteria of the species Thermus thermophilus possess different tiny hairs (pili) which are
used either to capture DNA or for motion. This has been discovered by
scientists at Goethe University Frankfurt and the University of Exeter. Graphic:
aduka, Agency Frankfurt am Main(www.aduka.de) for Goethe University Frankfurt.
Further information: Prof. Beate Averhoff, Molecular Microbiology and Bioenergetics. Tel.: +49 69 798-29509, averhoff@bio.uni-frankfurt.de, https://www.mikrobiologie-frankfurt.de
Computer models of merging neutron stars predicts how to tell when this happens
FRANKFURT. According to modern particle physics, matter
produced when neutron stars merge is so dense that it could exist in a state of
dissolved elementary particles. This state of matter, called quark-gluon
plasma, might produce a specific signature in gravitational waves. Physicists
at Goethe University Frankfurt and the Frankfurt Institute for Advanced Studies
have now calculated this process using supercomputers. (Physical Review
Letters, DOI 10.1103/PhysRevLett.124.171103)
Neutron stars are among the densest objects in the universe. If our Sun, with its radius of 700,000 kilometres were a neutron star, its mass would be condensed into an almost perfect sphere with a radius of around 12 kilometres. When two neutron stars collide and merge into a hyper-massive neutron star, the matter in the core of the new object becomes incredibly hot and dense. According to physical calculations, these conditions could result in hadrons such as neutrons and protons, which are the particles normally found in our daily experience, dissolving into their components of quarks and gluons and thus producing a quark-gluon plasma.
In 2017 it was discovered for the first
time that merging neutron stars send out a gravitational wave signal that can
be detected on Earth. The signal not only provides information on the nature of
gravity, but also on the behaviour of matter under extreme conditions. When these
gravitational waves were first discovered in 2017, however, they were not
recorded beyond the merging point.
This is where the work of the Frankfurt
physicists begins. They simulated merging neutron stars and the product of the
merger to explore the conditions under which a transition from hadrons to a quark-gluon
plasma would take place and how this would affect the corresponding
gravitational wave. The result: in a specific, late phase of the life of the
merged object a phase transition to the quark-gluon plasma took place and left a clear and characteristic signature on
the gravitational-wave signal.
Professor Luciano Rezzolla from Goethe
University is convinced: “Compared to previous simulations, we have discovered
a new signature in the gravitational waves that is significantly clearer to
detect. If this signature occurs in the gravitational waves that we will receive
from future neutron-star mergers, we would have a clear evidence for the
creation of quark-gluon plasma in the present universe."
Publication: Post-merger gravitational wave signatures of phase transitions in binary mergers. Lukas R. Weih, Matthias Hanauske, Luciano Rezzolla, Physical Review Letters Physical Review Letters DOI 10.1103/PhysRevLett.124.171103 https://link.aps.org/doi/10.1103/PhysRevLett.124.171103
Video:
Visualisation of merging neutron stars: https://www.youtube.com/watch?v=rj-r-YA9d6E&t=1s
This simulation shows the density of the
ordinary matter (mostly neutrons) in red-yellow. Shortly after the two stars
merge the extremely dense centre turns green, depicting the formation of the
quark-gluon plasma.
Pictures
may be downloaded here: http://www.uni-frankfurt.de/87973606
Caption
Montage: Montage of the computer simulation of two
merging neutron stars that blends over with an image from heavy-ion collisions
to highlight the connection of astrophysics with nuclear physics. Credit: Lukas
R. Weih & Luciano Rezzolla (Goethe University Frankfurt) (right half of the
image from cms.cern)
Caption
Simulation: Shortly after two neutron stars merge a
quark gluon plasma forms in the centre of the new object. Red yellow: ordinary
matter, mostly neutrons. Credit: Lukas R. Weih & Luciano Rezzolla (Goethe
University Frankfurt)
Further information: Goethe University Frankfurt, Prof. Dr. Luciano Rezzolla, Chair of Theoretical Astrophysics, Institute for Theoretical Physics, +49-69-79847871/47879, rezzolla@itp.uni-frankfurt.de, https://astro.uni-frankfurt.de/rezzolla/