Publications

6 REVIEWS representing our work

Mirus O & Schleiff E (2012) Recycling and Tinkering - The evolution of protein transport to and into endosymbiotically derived organelles.
In Organelle Genetics - Evolution of Organelle Genomes and Gene Expression, Bullerwell CE (ed) pp. 175–216. Springer Verlag Berlin.

Hahn A & Schleiff E (2014) The Cell Envelope.
In The Cell Biology of Cyanobacteria, Flores E & and Herrero A (eds) pp. 29–87. Caister Academic Press – Norfolk, UK.

Scharf KD, Berberich T, Ebersberger I & Nover L (2012) The plant heat stress transcription factor (Hsf) family: structure, function and evolution.
Biochim Biophys Acta 1819: 104–119.

Schleiff E & Becker T (2011) Common ground for protein translocation: access control for mitochondria and chloroplasts.
Nat Rev Mol Cell Biol 12: 48–59.

Weis BL, Schleiff E & Zerges W (2012) Protein targeting to subcellular organelles via mRNA localization.
Biochimica et Biophysica Acta - Mol Cell Research. 1833:260–273.

Weis BL, Kovacevic J, Missbach S, Schleiff E (2015) Plant-Specific Features of Ribosome Biogenesis.
Trends Plant Sci. 2015 Nov;20(11):729-40.

PUBLICATIONS 2016-2022
(Research Articles, Reviews & Bookchapters)

2022

Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions.
Rosenkranz RRE, Ullrich S, Löchli K, Simm S, Fragkostefanakis S. Front Plant Sci. 2022 Jun 23;13:911277. doi: 10.3389/fpls.2022.911277

Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants.
Broft P, Rosenkranz R, Schleiff E, Hengesbach M, Schwalbe H. RNA Biol. 2022;19(1):266-278. doi: 10.1080/15476286.2021.2024034

Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium.
Yadav S, Centola M, Glaesmann M, Pogoryelov D, Ladig R, Heilemann M, Rai LC, Yildiz Ö, Schleiff E. Nat Commun. 2022 Mar 30;13(1):1690. doi: 10.1038/s41467-022-29211-w.

Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation.
Fester N, Zielonka E, Goldmann J, Frombach AS, Müller-Kuller U, Gutfreund N, Riegel K, Smits JGA, Schleiff E, Rajalingam K, Zhou H, Simm S, Dötsch V. Cell Death Dis. 2022 Mar 4;13(3):204. doi: 10.1038/s41419-022-04659-2.

An Epigenetic Alphabet of Crop Adaptation to Climate Change.
Guarino F, Cicatelli A, Castiglione S, Agius DR, Orhun GE, Fragkostefanakis S, Leclercq J, Dobránszki J, Kaiserli E, Lieberman-Lazarovich M, Sõmera M, Sarmiento C, Vettori C, Paffetti D, Poma AMG, Moschou PN, Gašparović M, Yousefi S, Vergata C, Berger MMJ, Gallusci P, Miladinović D, Martinelli F. Front Genet. 2022 Feb 16;13:818727. doi: 10.3389/fgene.2022.818727. eCollection 2022.

HsfA7 coordinates the transition from mild to strong heat stress response by controlling the activity of the master regulator HsfA1a in tomato.
Mesihovic A, Ullrich S, Rosenkranz RRE, Gebhardt P, Bublak D, Eich H, Weber D, Berberich T, Scharf KD, Schleiff E, Fragkostefanakis S. Cell Rep. 2022 Jan 11;38(2):110224. doi: 10.1016/j.celrep.2021.110224. PMID: 35021091

Retrograde Analysis of Calcium Signaling by CaMPARI2 Shows Cytosolic Calcium in Chondrocytes Is Unaffected by Parabolic Flights.
Hammer A, Cerretti G, Ricciardi DA, Schiffmann D, Maranda S, Kummer R, Zumbühl C, Rattenbacher-Kiser KF, von Arx S, Ammann S, Strobl F, Berkane R, Stolz A, Stelzer EHK, Egli M, Schleiff E, Wuest SL, Böhmer M.Biomedicines. 2022 Jan 8;10(1):138. doi: 10.3390/biomedicines10010138.

Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants.
Broft P, Rosenkranz R, Schleiff E, Hengesbach M, Schwalbe H. RNA Biol. 2022 Jan;19(1):266-278. doi: 10.1080/15476286.2021.2024034

2021

The Arabidopsis 2'-O-Ribose-Methylation and Pseudouridylation Landscape of rRNA in Comparison to Human and Yeast.
Streit D, Schleiff E. Front Plant Sci. 2021 Jul 26;12:684626. doi: 10.3389/fpls.2021.684626. eCollection 2021. PMID: 34381476

Dynamics and thermal sensitivity of ribosomal RNA maturation paths in plants.
Shanmugam T, Streit D, Schroll F, Kovacevic J, Schleiff E. J Exp Bot. 2021 Sep 30:erab434. doi: 10.1093/jxb/erab434. Online ahead of print. PMID: 34591082

Functional Diversity of TonB-Like Proteins in the Heterocyst-Forming Cyanobacterium Anabaena sp. PCC 7120.
Schätzle H, Arévalo S, Fresenborg L, Seitz HM, Flores E, Schleiff E. mSphere. 2021 Nov 17;6(6):e0021421. doi: 10.1128/mSphere.00214-21. Online ahead of print. PMID: 34787445 

A TonB-Like Protein, SjdR, Is Involved in the Structural Definition of the Intercellular Septa in the Heterocyst-Forming Cyanobacterium Anabaena.
Schätzle H, Arévalo S, Flores E, Schleiff E. mBio. 2021 Jun 29;12(3):e0048321. doi: 10.1128/mBio.00483-21. Epub 2021 Jun 8. PMID: 34101487

Identification and Regulation of Tomato Serine/Arginine-Rich Proteins Under High Temperatures.
Rosenkranz RRE, Bachiri S, Vraggalas S, Keller M, Simm S, Schleiff E, Fragkostefanakis S. Front Plant Sci. 2021 Mar 29;12:645689. doi: 10.3389/fpls.2021.645689. PMID: 33854522; PMCID: PMC8039515

Comparative Phenotypic Analysis of Anabaena sp. PCC 7120 Mutants of Porinlike Genes.
Schätzle H, Brouwer EM, Liebhart E, Stevanovic M, Schleiff E. J Microbiol Biotechnol. 2021 May 28;31(5):645-658. doi: 10.4014/jmb.2103.03009. PMID: 33879642

The Two TpsB-Like Proteins in Anabaena sp. Strain PCC 7120 Are Involved in Secretion of Selected Substrates.
Ngo G, Girbas M, Schätzle H, Hammer A, Safarian S, Hübinger M, Schleiff E. J Bacteriol. 2021 Jan 25;203(4):e00568-20. doi: 10.1128/JB.00568-20. Print 2021 Jan 25. PMID: 33257527

Insertion of plastidic β-barrel proteins into the outer envelopes of plastids involves an intermembrane space intermediate formed with Toc75-V/OEP80.
Gross LE, Klinger A, Spies N, Ernst T, Flinner N, Simm S, Ladig R, Bodensohn U, Schleiff E. Plant Cell. 2021 Feb 24:koab052. doi: 10.1093/plcell/koab052. PMID: 33624803

2020

Membrane Extracts from Plant Tissues.
Bodensohn U, Ruland C, Ladig R, Schleiff E. Methods Mol Biol. 2020;2127:81-92. doi: 10.1007/978-1-0716-0373-4_6. PMID: 32112316

LptC from Anabaena sp. PCC 7120: Expression, purification and crystallization.
Ngo G, Centola M, Krasnoselska G, Pogoryelov D, Yildiz Ö, Schleiff E. Protein Expr Purif. 2020 Nov;175:105689. doi: 10.1016/j.pep.2020.105689. Epub 2020 Jul 19. PMID: 32698044

The Existence and Localization of Nuclear snoRNAs in Arabidopsis thaliana Revisited.
Streit D, Shanmugam T, Garbelyanski A, Simm S, Schleiff E. Plants (Basel). 2020 Aug 12;9(8):1016. doi: 10.3390/plants9081016. PMID: 32806552

Structural and Functional Heat Stress Responses of Chloroplasts of Arabidopsis thaliana.
Paul P, Mesihovic A, Chaturvedi P, Ghatak A, Weckwerth W, Böhmer M, Schleiff E. Genes (Basel). 2020 Jun 12;11(6):650. doi: 10.3390/genes11060650. PMID: 32545654

Transcriptional Basis for Differential Thermosensitivity of Seedlings of Various Tomato Genotypes.
Hu Y, Fragkostefanakis S, Schleiff E, Simm S. Genes (Basel). 2020 Jun 16;11(6):655. doi: 10.3390/genes11060655. PMID: 32560080

miRNAs involved in transcriptome remodeling during pollen development and heat stress response in Solanum lycopersicum.
Keller M, Schleiff E, Simm S. Sci Rep. 2020 Jul 1;10(1):10694. doi: 10.1038/s41598-020-67833-6. PMID: 32612181

Reprogramming of Tomato Leaf Metabolome by the Activity of Heat Stress Transcription Factor HsfB1.
Paupière MJ, Tikunov Y, Schleiff E, Bovy A, Fragkostefanakis S. Front Plant Sci. 2020 Dec 23;11:610599. doi: 10.3389/fpls.2020.610599. eCollection 2020. PMID: 33424907

Natural variation in HsfA2 pre-mRNA splicing is associated with changes in thermotolerance during tomato domestication.
Hu Y, Mesihovic A, Jiménez-Gómez JM, Röth S, Gebhardt P, Bublak D, Bovy A, Scharf KD, Schleiff E, Fragkostefanakis S. New Phytol. 2020 Feb;225(3):1297-1310. doi: 10.1111/nph.16221. Epub 2019 Nov 14. PMID: 31556121

Toc75-V/OEP80 is processed during translocation into chloroplasts, and the membrane-embedded form exposes its POTRA domain to the intermembrane space.
Gross LE, Spies N, Simm S, Schleiff E. FEBS Open Bio. 2020 Mar;10(3):444-454. doi: 10.1002/2211-5463.12791. Epub 2020 Feb 17. PMID: 31953987

2019

Metalloproteins in the Biology of Heterocysts.
Pernil R, Schleiff E. Life (Basel). 2019 Apr 3;9(2):32. doi: 10.3390/life9020032. PMID: 30987221 Review.

Citrus exocortis viroid causes ribosomal stress in tomato plants.
Cottilli P, Belda-Palazón B, Adkar-Purushothama CR, Perreault JP, Schleiff E, Rodrigo I, Ferrando A, Lisón P. Nucleic Acids Res. 2019 Sep 19;47(16):8649-8661. doi: 10.1093/nar/gkz679. PMID: 31392997

The intracellular distribution of the components of the GET system in vascular plants.
Bodensohn US, Simm S, Fischer K, Jäschke M, Groß LE, Kramer K, Ehmann C, Rensing SA, Ladig R, Schleiff E. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1650-1662. doi: 10.1016/j.bbamcr.2019.06.012. Epub 2019 Jun 21. PMID: 31233800.

Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing.
Palm D, Streit D, Shanmugam T, Weis BL, Ruprecht M, Simm S, Schleiff E. Nucleic Acids Res. 2019 Feb 28;47(4):1880-1895. doi: 10.1093/nar/gky1261. PMID: 30576513

Regulation of two GTPases Toc159 and Toc34 in the translocon of the outer envelope of chloroplasts.
Wiesemann K, Simm S, Mirus O, Ladig R, Schleiff E. Biochim Biophys Acta Proteins Proteom. 2019 Jun;1867(6):627-636. doi: 10.1016/j.bbapap.2019.01.002. Epub 2019 Jan 3. PMID: 30611779

Functional diversification of tomato HsfA1 factors is based on DNA binding domain properties.

El-Shershaby A, Ullrich S, Simm S, Scharf KD, Schleiff E, Fragkostefanakis S. Gene. 2019 Sep 25;714:143985. doi: 10.1016/j.gene.2019.143985. Epub 2019 Jul 19. PMID: 31330236

Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors.

Kovacevic J, Palm D, Jooss D, Bublak D, Simm S, Schleiff E. Plant Cell Rep. 2019 Aug;38(8):937-949. doi: 10.1007/s00299-019-02416-y. Epub 2019 May 13. PMID: 31087154

HEATSTER: A Database and Web Server for Identification and Classification of Heat Stress Transcription Factors in Plants.
Berz J, Simm S, Schuster S, Scharf KD, Schleiff E, Ebersberger I. Bioinform Biol Insights. 2019 Jan 7;13:1177932218821365. doi: 10.1177/1177932218821365. eCollection 2019. PMID: 30670918

The signal distinguishing between targeting of outer membrane β-barrel protein to plastids and mitochondria in plants.
Klinger A, Gosch V, Bodensohn U, Ladig R, Schleiff E. Biochim Biophys Acta Mol Cell Res. 2019 Apr;1866(4):663-672. doi: 10.1016/j.bbamcr.2019.01.004. Epub 2019 Jan 8. PMID: 30633951

Identification and Characterization of a Thermotolerant TILLING Allele of Heat Shock Binding Protein 1 in Tomato.
Marko D, El-Shershaby A, Carriero F, Summerer S, Petrozza A, Iannacone R, Schleiff E, Fragkostefanakis S. Genes (Basel). 2019 Jul 7;10(7):516. doi: 10.3390/genes10070516. PMID: 31284688

Microgravity research in plants: A range of platforms and options allow research on plants in zero or low gravity that can yield important insights into plant physiology.
Böhmer M, Schleiff E. EMBO Rep. 2019 Jul;20(7):e48541. doi: 10.15252/embr.201948541. Epub 2019 Jun 14. PMID: 31267713

Tic22 from Anabaena sp. PCC 7120 with holdase function involved in outer membrane protein biogenesis shuttles between plasma membrane and Omp85.
Brouwer EM, Ngo G, Yadav S, Ladig R, Schleiff E. Mol Microbiol. 2019 May;111(5):1302-1316. doi: 10.1111/mmi.14222. Epub 2019 Mar 18. PMID: 30742726

2018

Late ribosomal protein localization in Arabidopsis thaliana differs to that in Saccharomyces cerevisiae.
Palm D, Streit D, Ruprecht M, Simm S, Scharf C, Schleiff E. FEBS Open Bio. 2018 Jul 25;8(9):1437-1444. doi: 10.1002/2211-5463.12487. eCollection 2018 Sep. PMID: 30186745

Pyridine 2,4-Dicarboxylic Acid Suppresses Tomato Seedling Growth.
Fragkostefanakis S, Kaloudas D, Kalaitzis P. Front Chem. 2018 Jan 30;6:3. doi: 10.3389/fchem.2018.00003. eCollection 2018. PMID: 29441347 Free PMC article.

The repressor and co-activator HsfB1 regulates the major heat stress transcription factors in tomato.
Fragkostefanakis S, Simm S, El-Shershaby A, Hu Y, Bublak D, Mesihovic A, Darm K, Mishra SK, Tschiersch B, Theres K, Scharf C, Schleiff E, Scharf KD. Plant Cell Environ. 2019 Mar;42(3):874-890. doi: 10.1111/pce.13434. Epub 2018 Oct 11. PMID: 30187931

The coupling of transcriptome and proteome adaptation during development and heat stress response of tomato pollen.
Keller M; SPOT-ITN Consortium, Simm S. BMC Genomics. 2018 Jun 8;19(1):447. doi: 10.1186/s12864-018-4824-5. PMID: 29884134

2017

Alternative splicing in tomato pollen in response to heat stress.
Keller M, Hu Y, Mesihovic A, Fragkostefanakis S, Schleiff E, Simm S. DNA Res. 2017 Apr 1;24(2):205-217. doi: 10.1093/dnares/dsw051. PMID: 28025318

The plastid outer membrane localized LPTD1 is important for glycerolipid remodelling under phosphate starvation.
Hsueh YC, Ehmann C, Flinner N, Ladig R, Schleiff E. Plant Cell Environ. 2017 Aug;40(8):1643-1657. doi: 10.1111/pce.12973. Epub 2017 Jun 2. PMID: 28433003 Free article.

Chloroplast outer envelope protein P39 in Arabidopsis thaliana belongs to the Omp85 protein family.
Hsueh YC, Flinner N, Gross LE, Haarmann R, Mirus O, Sommer MS, Schleiff E. Proteins. 2017 Aug;85(8):1391-1401. doi: 10.1002/prot.24725. Epub 2017 Jun 12. PMID: 25401771

Nucleolar Proteome Analysis and Proteasomal Activity Assays Reveal a Link between Nucleolus and 26S Proteasome in A. thaliana.
Montacié C, Durut N, Opsomer A, Palm D, Comella P, Picart C, Carpentier MC, Pontvianne F, Carapito C, Schleiff E, Sáez-Vásquez J. Front Plant Sci. 2017 Oct 20;8:1815. doi: 10.3389/fpls.2017.01815. eCollection 2017. PMID: 29104584

DNA-binding and repressor function are prerequisites for the turnover of the tomato heat stress transcription factor HsfB1.
Röth S, Mirus O, Bublak D, Scharf KD, Schleiff E. Plant J. 2017 Jan;89(1):31-44. doi: 10.1111/tpj.13317. Epub 2016 Nov 14. PMID: 27560701

Modeling the Metabolism of Arabidopsis thaliana: Application of Network Decomposition and Network Reduction in the Context of Petri Nets.
Koch I, Nöthen J, Schleiff E. Front Genet. 2017 Jun 30;8:85. doi: 10.3389/fgene.2017.00085. eCollection 2017. PMID: 28713420

2016

Pollen as a target of environmental changes.
Grover A, Twell D, Schleiff E. Plant Reprod. 2016 Jun;29(1-2):1-2. doi: 10.1007/s00497-016-0285-7. PMID: 27282498

Unfolded protein response in pollen development and heat stress tolerance.
Fragkostefanakis S, Mesihovic A, Hu Y, Schleiff E. Plant Reprod. 2016 Jun;29(1-2):81-91. doi: 10.1007/s00497-016-0276-8. Epub 2016 Mar 29. PMID: 27022919 Review.

Importance of organellar proteins, protein translocation and vesicle transport routes for pollen development and function.
Paul P, Röth S, Schleiff E. Plant Reprod. 2016 Jun;29(1-2):53-65. doi: 10.1007/s00497-016-0274-x. Epub 2016 Feb 13. PMID: 26874709 Review.

Characterization of the targeting signal in mitochondrial β-barrel proteins.
Jores T, Klinger A, Groß LE, Kawano S, Flinner N, Duchardt-Ferner E, Wöhnert J, Kalbacher H, Endo T, Schleiff E, Rapaport D. Nat Commun. 2016 Jun 27;7:12036. doi: 10.1038/ncomms12036. PMID: 27345737

Eukaryotic Hsp70 chaperones in the intermembrane space of chloroplasts.
Bionda T, Gross LE, Becker T, Papasotiriou DG, Leisegang MS, Karas M, Schleiff E. Planta. 2016 Mar;243(3):733-47. doi: 10.1007/s00425-015-2440-z. Epub 2015 Dec 15. PMID: 26669598

The membrane proteome of male gametophyte in Solanum lycopersicum.
Paul P, Chaturvedi P, Selymesi M, Ghatak A, Mesihovic A, Scharf KD, Weckwerth W, Simm S, Schleiff E. J Proteomics. 2016 Jan 10;131:48-60. doi: 10.1016/j.jprot.2015.10.009. Epub 2015 Oct 9. PMID: 26455813

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10.
Ellenrieder L, Opaliński Ł, Becker L, Krüger V, Mirus O, Straub SP, Ebell K, Flinner N, Stiller SB, Guiard B, Meisinger C, Wiedemann N, Schleiff E, Wagner R, Pfanner N, Becker T. Nat Commun. 2016 Oct 10;7:13021. doi: 10.1038/ncomms13021. PMID: 27721450

Proteome distribution between nucleoplasm and nucleolus and its relation to ribosome biogenesis in Arabidopsis thaliana.
Palm D, Simm S, Darm K, Weis BL, Ruprecht M, Schleiff E, Scharf C. RNA Biol. 2016;13(4):441-54. doi: 10.1080/15476286.2016.1154252. Epub 2016 Mar 16. PMID: 26980300

Multiplicity and specificity of siderophore uptake in the cyanobacterium Anabaena sp. PCC 7120.
Rudolf M, Stevanovic M, Kranzler C, Pernil R, Keren N, Schleiff E.
Plant Mol Biol. 2016 Sep;92(1-2):57-69. doi: 10.1007/s11103-016-0495-2. Epub 2016 Jun 20. PMID: 27325117

Relative Orientation of POTRA Domains from Cyanobacterial Omp85 Studied by Pulsed EPR Spectroscopy.
Dastvan R, Brouwer EM, Schuetz D, Mirus O, Schleiff E, Prisner TF. Biophys J. 2016 May 24;110(10):2195-206. doi: 10.1016/j.bpj.2016.04.030. PMID: 27224485

Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways.
Heininger AU, Hackert P, Andreou AZ, Boon KL, Memet I, Prior M, Clancy A, Schmidt B, Urlaub H, Schleiff E, Sloan KE, Deckers M, Lührmann R, Enderlein J, Klostermeier D, Rehling P, Bohnsack MT. RNA Biol. 2016;13(3):320-30. doi: 10.1080/15476286.2016.1142038. Epub 2016 Jan 29. PMID: 26821976

50 years of amino acid hydrophobicity scales: revisiting the capacity for peptide classification.
Simm S, Einloft J, Mirus O, Schleiff E. Biol Res. 2016 Jul 4;49(1):31. doi: 10.1186/s40659-016-0092-5. PMID: 27378087

HsfA2 Controls the Activity of Developmentally and Stress-Regulated Heat Stress Protection Mechanisms in Tomato Male Reproductive Tissues.
Fragkostefanakis S, Mesihovic A, Simm S, Paupière MJ, Hu Y, Paul P, Mishra SK, Tschiersch B, Theres K, Bovy A, Schleiff E, Scharf KD. Plant Physiol. 2016 Apr;170(4):2461-77. doi: 10.1104/pp.15.01913. Epub 2016 Feb 25. PMID: 26917685

Survey of Genes Involved in Biosynthesis, Transport, and Signaling of Phytohormones with Focus on Solanum lycopersicum.
Simm S, Scharf KD, Jegadeesan S, Chiusano ML, Firon N, Schleiff E. Bioinform Biol Insights. 2016 Sep 26;10:185-207. doi: 10.4137/BBI.S38425. eCollection 2016. PMID: 27695302

Heat stress regimes for the investigation of pollen thermotolerance in crop plants.
Mesihovic A, Iannacone R, Firon N, Fragkostefanakis S. Plant Reprod. 2016 Jun;29(1-2):93-105. doi: 10.1007/s00497-016-0281-y. Epub 2016 Mar 25. PMID: 27016360



Kontakt

Prof. Dr. Enrico Schleiff
Biocentre, Campus Riedberg
Building N200, Room 302
Max-von-Laue-Str. 9
60438 Frankfurt am Main

T +49 69 798-29287
F +49 69 798-29286
E schleiff@bio.uni-frankfurt.de