Institute for Molecular Bio Science

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Research

There are currently eleven working groups at the Institute; they investigate a wide variety of molecular aspects of life. This research primarily focuses on microorganisms and plants. Membrane Biology is traditionally one of the strongest areas at the Institute. In this context, the focal point is the analysis of the structure and function of membrane-bound proteins, as well as their regulation and participation in intracellular signalling cascades. In the field of Biotechnology, work is being conducted on the development of microbial cell factories using both classical and recombinant methods to bring about overproduction of a range of enzymes and chemicals. Another new aspect of this field is the identification, characterisation and application of new metabolites from the secondary metabolism of entomopathogenic microbes. Metabolic pathways are selectively altered, e.g. to produce biofuels or to develop therapeutic methods of improving cellular defence.

In Microbial Physiology the emphasis is on metabolic physiology, specifically on its regulation and genetic basis in the Archaea, Bacteria and Eukaryota. The results of this study form the basis of analysis by membrane biologists and biotechnologists, leading to close networking both within the faculty and beyond. Research topics in Molecular Plant Physiology are the energy metabolism of photosynthetic organisms and its underlying organelle interactions. Physiological, structural, biochemical and genetic investigation all play an important part in this research.

Degenerative Processes and Molecular Stress focuses on the investigation of molecular aging mechanisms, especially the role of mitochondria in the aging process, as well as the analysis of cellular responses to heat and light stress. The groups working on Protective Functions of Carotenoids are investigating the molecular mechanism of carotenoid function in strong light conditions, as well as in protection from reactive oxygen species and membrane damage caused by external factors. In the field of Regulatory RNAs, the research focuses on structural and functional analysis of regulatory non-coding RNAs and their interactions with proteins, as well as their biological functions and cellular regulation.

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Resarch Objects




Department


Title


First Name



Surname

Biology and Genetics of Procaryotes


Prof.


Jörg



Soppa

Natural Product Genomics


Prof.


Eric



Helfrich

Merck-Stiftungsprofessur Molecular Biotechnology


Prof.


Helge



Bode

Molecular Microbiology and Bioenergetics


Prof.


Volker 



Müller

Molecular Microbiology and Bioenergetics


Prof.


Beate



Averhoff

Molecular Cell Biology of Plants


Prof.


Enrico



Schleiff

mRNA-based gene regulation


Prof.


Andreas



Schlundt

Plant Cell Physiology


Prof.


Claudia



Büchel

Physiology and Genetics of Lower Eukaryotes


Prof.


Eckhard



Boles

RNA Regulation in Higher Eukaryotes


Prof.


Michaela



Müller-McNicoll

RNA Structural Biology


Prof.


Jens



Wöhnert



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Teaching

The Institute is involved the Bachelor's Programmes in Biological Sciences, Biophysics and Bioinformatics as well as in Teacher Education in Biological Sciences and in the biological training of medical science students. In addition, it offers two master's programmes, Molecular Biological Sciences and Molecular Biotechnology, as well as participating in interdisciplinary master's programmes.

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Colloquium

The talks starts at 17:15 

Campus Rieberg, Biocenter, Section of the Building 260 Room 3.13

Tuesday, February 21, 2023

Prof. Ben Shen

University of Florida, USA

Leverage a Large Actinobacterial Strain Collection for Natural Products and Drug Discovery

The Natural Products Discovery Center (NPDC) at UF Scripps houses one of the world's largest actinobacterial strain collections, totaling ~125,000 strains.  These strains, isolated over the last eight decades and from 69 different countries, encode natural product chemical and biological diversity that are impossible to reproduce in laboratory settings today.  We have launched a large-scale genome sequencing campaign to sequence all actinobacterial strains in the collection.  The sequenced genomes are curated to create the NPGRC database.  Both the strains and the curated genomes have been made available to the scientific community to promote natural products training, research, and associated applications (https://npdc.rc.ufl.edu/home).  Lessons learned from our natural products program over the years and preliminary analysis of the strains sequenced to date, benchmarking against the sequenced genomes available in the public databases, will be presented to highlight how such a community resource could radically transform the current paradigm of natural product studies and drug discovery.

Invited by Prof. Helfrich


How to get there:

Open Street Map, Google Maps, pdf

Contact

Institute for Moelcular Bio Science

Campus Riedberg
Biocentre

Building N210-207
Post office box 6
Max-von-Laue-Str. 9
D-60438 Frankfurt

T +49 69 798-29603
F +49 69 798-29600
info-mbw@bio.uni-frankfurt.de

Managing Director:
Prof. Dr. Jens Wöhnert

Assis. Managing Director:
Prof. Dr. Michaela Müller-McNicoll

Further information: eMail
Dr. Markus Fauth
Tel: 069 798 29603
Dr. Matthias Rose
Tel: 069 798 29529

Secretary: Brunhilde Schönberger

Campus Riedberg
Biozentrum N250 0.05
Max-von-Laue-Straße 9
60438 Frankfurt
Tel: 069 798 29558