Institute for Molecular Bio Science

Research

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Research

There are currently eleven working groups at the Institute; they investigate a wide variety of molecular aspects of life. This research primarily focuses on microorganisms and plants. Membrane Biology is traditionally one of the strongest areas at the Institute. In this context, the focal point is the analysis of the structure and function of membrane-bound proteins, as well as their regulation and participation in intracellular signalling cascades. In the field of Biotechnology, work is being conducted on the development of microbial cell factories using both classical and recombinant methods to bring about overproduction of a range of enzymes and chemicals. Another new aspect of this field is the identification, characterisation and application of new metabolites from the secondary metabolism of entomopathogenic microbes. Metabolic pathways are selectively altered, e.g. to produce biofuels or to develop therapeutic methods of improving cellular defence.

In Microbial Physiology the emphasis is on metabolic physiology, specifically on its regulation and genetic basis in the Archaea, Bacteria and Eukaryota. The results of this study form the basis of analysis by membrane biologists and biotechnologists, leading to close networking both within the faculty and beyond. Research topics in Molecular Plant Physiology are the energy metabolism of photosynthetic organisms and its underlying organelle interactions. Physiological, structural, biochemical and genetic investigation all play an important part in this research.

Degenerative Processes and Molecular Stress focuses on the investigation of molecular aging mechanisms, especially the role of mitochondria in the aging process, as well as the analysis of cellular responses to heat and light stress. The groups working on Protective Functions of Carotenoids are investigating the molecular mechanism of carotenoid function in strong light conditions, as well as in protection from reactive oxygen species and membrane damage caused by external factors. In the field of Regulatory RNAs, the research focuses on structural and functional analysis of regulatory non-coding RNAs and their interactions with proteins, as well as their biological functions and cellular regulation.

Research Objects

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Research Objects

Department     Title   First Name     Surname

Biology and Biotechnology of Fungi

   

Prof.

 

Richard

   

Splivallo

Biology and Genetics of Procaryotes

   

Prof.

 

Jörg

   

Soppa

Biosynthesis in Plants und Microorganism

   

Prof.

 

Gerhard

   

Sandmann

Merck-Stiftungsprofessur Molecular Biotechnology

   

Prof.

 

Helge

   

Bode

Molecular Developmental Biology

   

Prof.

 

Heinz Dieter

   

Osiewacz

Molecular Microbiology and Bioenergetics

   

Prof.

 

Volker 

   

Müller

Molecular Microbiology and Bioenergetics

   

Prof.

 

Beate

   

Averhoff

Molecular Cell Biology of Plants

   

Prof.

 

Enrico

   

Schleiff

mRNA-based gene regulation

   

Dr.

 

Andreas

   

Schlundt

Plant Cell Physiology

   

Prof.

 

Claudia

   

Büchel

Physiology and Genetics of Lower Eukaryotes

   

Prof.

 

Eckhard

   

Boles

RNA Structural Biology

   

Prof.

 

Jens

   

Wöhnert

Heads of the Departments

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Heads of the Departments

Title   First Name   Surname   Department  
               

Prof.

 

Beate

 

Averhoff

 

Molecular Microbiology and Bioenergetics

 

Prof.

 

Helge

 

Bode

 

Merck-Stiftungsprofessur Molecular Biotechnology

 

Prof.

 

Eckhard

 

Boles

 

Physiology and Genetics of Lower Eukaryotes

 

Prof.

 

Claudia

 

Büchel

 

Plant Cell Physiology

 

Prof.

 

Volker 

 

Müller

 

Molecular Microbiology and Bioenergetics

 

Prof.

 

Heinz Dieter

 

Osiewacz

 

Molecular Developmental Biology

 

Prof.

 

Gerhard

 

Sandmann

 

Biosynthesis in Plants und Microorganism

 

Prof.

 

Enrico

 

Schleiff

 

Molecular Cell Biology of Plants

 

Dr.

 

Andreas

 

Schlundt

 

mRNA-based gene regulation

 

Prof.

 

Jörg

 

Soppa

 

Biology and Genetics of Procaryotes

 

Prof.

 

Richard

 

Splivallo

 

Biology and Biotechnology of Fungi

 

Prof.

 

Jens

 

Wöhnert

 

RNA Structural Biology

 

Teaching

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Teaching

The Institute is involved the Bachelor's Programmes in Biological Sciences, Biophysics and Bioinformatics as well as in Teacher Education in Biological Sciences and in the biological training of medical science students. In addition, it offers two master's programmes, Molecular Biological Sciences and Molecular Biotechnology, as well as participating in interdisciplinary master's programmes.

Kolloquium

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Kolloquium

Wintersemester 2018/2019

  • Die Vorträge finden jeweils um 17:15 Uhr statt.
    The talks starts at 17:15
  • Ort: Biozentrum auf dem Campus Riedberg, Raum 260/3.13
    Where:  Campus Rieberg, Biocenter, Section of the Building 260 Room 3.13
Tuesday 16.10.2018  

Dr. Jose M Jimenez-Gomez
Institut Jean Pierre Bourgain INRA-Versailles, Frankreich

Domestication delayed circadian rhythms in tomato


Tuesday 23.10.2018  

Dr. Andreas Schlundt
Institut Molekulare Biowissenschaften, Goethe Universität

Towards atom-resolved RNA-protein landscapes that egotiate mRNA fate


Tuesday 06.11.2018  

Dr. Xavier Charpentier, International Center for Research on Infectious Diseases Villeurbanne, France

Natural transformation and acquisition of antibiotic resistance in Acinetobacter baumannii


Tuesday 20.11.2018  

Dr. Mirko Basen
Institut Molekulare Biowissenschaften, Goethe Universität

Thermophiles - from basic physiology towards biotechnological applications


Tuesday 29.01.2019  

Dr. Daniel Kögler
Martin Luther Universität, Halle an der Saale

The protein import machinery at the plastid envelope membrane comprises subunits that connect protein import with other essential plastidic processes

The plastid depends on the import of several hundred nucleus-encoded proteins. The main import route for these proteins entails the translocons at the outer (TOC) and inner (TIC) chloroplast envelope membrane. Recently a 1 MDa complex at the inner envelope membrane was discovered, that does not only function in plastid protein import but also seems to be important for other plastidic processes. One of the components of this complex is Tic56. This protein is important for the accumulation of the other 1 MDa-TIC-complex components and thus for the formation of the 1 MDa complex. In our hands a defect in Tic56 has no consequence for plastid protein import. Instead, the loss of the 1 MDa-TIC- complex component Tic56 leads to a reduction of plastid ribosomal proteins and a processing defect of the 23S rRNA, indicating that Tic56 and the 1 MDa-TIC-complex are critical for plastid ribosome biogenesis and consequently for plastid translation. Thus our findings reveal a link between plastid protein import and synthesis of plastid encoded proteins.


Tuesday 05.02.2019  

Prof. Dr. Andres Jäschke
Universität Heidelberg

Chemical Biology of RNA - New epitranscriptomic modifications and novel imaging approaches


     

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