Press releases – October 2018

FRANKFURT/GIESSEN. With their joint application for an excellence cluster, Goethe University Frankfurt and Justus-Liebig-University Giessen asserted themselves successfully against strong competition. The German Research Foundation announced on 27^th September, that the “Cardiopulmonary Institute” (CPI) application, along with 56 other Excellence Cluster projects nationwide, will receive funding for the next seven years.

University President Professor Birgitta Wolff says: “Congratulations to our colleagues in Frankfurt, Giessen and Bad Nauheim, who fought with great success for their scientific ideas and concepts with an excellent application amid a field of strong competitors. The culture of cooperation that has emerged over the course of nearly twelve years among the partners was undoubtedly a decisive moment for this achievement. The formal foundation as an interuniversity institute is new, as is a more developed substantive approach. This latest achievement demonstrates that the effort and investment put into university cardiovascular research paid off.”

Professor Stefanie Dimmeler, lead scientist for Goethe University, emphasizes: “We are thrilled about this huge success which would not have been possible without the support of our great team. The funding of the ‘Cardiopulmonary Institute’ will allow us to create a centre that is unique worldwide with the goal of better understanding heart and lung diseases and identifying new therapeutic options.”

Heart and lung diseases are among the most frequent causes of death worldwide, with multiple interactions between the two organs and challenges in treatment that have yet to be resolved. A coherent understanding of the molecular biology of the individual and cooperative cellular processes, which constitute the foundation of these organs’ homeostasis and their failure in the course of disease, is lacking along with the knowledge of how these processes could be used for new, individualized therapy concepts.

The consortium of the three partners consisting of basic and medical scientists and clinicians has already made fundamental contributions to cardiovascular research and therapeutic developments within the framework of the previously funded Excellence Cluster Cardio-Pulmonary System (ECCPS). The newly approved institute pursues new structural and programmatic paths with the vision of precision biology being the motor for precision medicine. This success is simultaneously an important signal for the sustained development of research strategy at Goethe University.

The joint institute is an interuniversity facility in accordance with §47 of the Hessen Higher Education Act. Within a short time, several new professorships and junior research groups will be set up to further strengthen work in future fields of cardio-vascular research. The CPI will finance cutting edge technologies and flexible innovation programs. The CPI Academy supports research-oriented teaching and promotes academic career development, such as a “science track” for medical students, support of MD and PhD programmes, the financing of career programmes for basic, medical and clinical researchers, and a mentoring programme.

With the new Excellence Cluster, the three partners also strengthen the scientific profile of the region, further enhancing its status in the area of cutting-edge medical research.

FRANKFURT. Following ten years at the renowned University of California San Diego (UCSD), cardiovascular researcher Dr. Nuno Guimarães Camboa is coming to Goethe University. He was lured by the DZHK (German Centre of Cardiovascular Research), which has 28 locations in Germany, one of which is Goethe University. The native Portuguese has been awarded a DZHK junior research group grant and will receive € 1.25m in the next five years to create a research group dedicated to basic research on cardiovascular diseases. 

A transcription factor is at the centre of Dr. Nuno Guimarães Camboa’s work. This is a protein which supports the copying of the DNA of the genetic code, “translating” it to RNA. From his previous research projects at the University of California, the junior researcher knows that a specific transcription factor, TBX18, is typically present in three cell types: smooth muscle cells that are found in vessel walls, pacemaker cells in the sino-atrial node (the structure responsible for setting the rhythm of cardiac contraction), and activated connective tissue cells in the injured heart. All three cell types are involved in dangerous cardiovascular diseases: dilations of the aorta (aortic aneurysms), cardiac arrhythmias and morbid proliferation of connective tissue in the heart (cardiac fibrosis). 

“We believe that TBX18 affects these cells’ functions”, says Guimarães Camboa. “This factor could therefore play a role in certain cardiovascular diseases.” With his DZHK junior research group at the Goethe University Frankfurt, he wants to investigate which genes are regulated by the transcription factor. The biologist is also planning the targeted inactivation of TBX18 in the relevant cell types. The consequences of this inactivation on the function of the cells will subsequently be closely analysed. “We thus want to better understand the signalling networks active in specific types of cardiovascular disease and hope to thereby improve their early detection and treatment”, explains Guimarães Camboa. 

Guimarães Camboa is coming to the DZHK partner site at Goethe University after ten years in the US. He both completed his doctorate and carried out a four-year PostDoc at the University of California. He previously concentrated on the heart’s formation during embryonic development. 

With the junior research groups, the DZHK wants to attract talented and qualified young scientists from Germany and abroad, and provide them with scientific independence early on. In addition to leading a research group, the young scientists also have teaching duties, so that they can qualify for a professorship. 

Further information: Dr. Nuno Guimarães Camboa, Institute for Cardiovascular Regeneration, University Hospital Frankfurt, ncamboa@med.uni-frankfurt.de . 

Image may be downloaded at: www.uni-frankfurt.de/73850305 
Photo: private

FRANKFURT. A new supercomputer, on course to set new standards in the field of green IT, is currently being developed at Goethe University under the leadership of Professor Volker Lindenstruth (professorship for supercomputer architecture). The tremendously energy-efficient computer, whose development costs are comparatively low, is based on a large number of high-performing, interconnected graphic cards, and a cooling system that utilizes river water from the Main. The water cooling system lowers the primary energy use for cooling to just about 8 %. Other computing centres require six to ten times this amount of energy for cooling. In 2014, a supercomputer built according to the Lindenstruth’s construction principle achieved the number one slot in the world ranking of energy-efficient supercomputers.

The new GOETHE supercomputer in the Industrial Park Höchst, which is to be realized according to a construction principle further optimized yet similar to its predecessor, will be constructed in two phases. The first construction phase will be concluded by 13^th December 2018 and cost approximately € 4.5m. The total costs amounting to € 7.5m will be financed by 50% from federal funds and by 50% from Goethe University and FIAS funds.

The result will be a supercomputer with 18,880 highly interconnected computing cores at its first stage. This translates into a tripling of the computing performance of the preceding model, the LOEWE-CSC, which also began operation in the Industrial Park Hoechst at the end of November 2010. At the time, it was the most energy-efficient supercomputer in Europe according to the international ranking “Green 500”.

On Monday in Frankfurt, Hessen Minister of Higher Education, Research and the Arts, Boris Rhein said: “The GOETHE supercomputer is crucial in order to realize research projects in the natural sciences, medicine, life sciences and economics. … With the approved funding, Goethe University will receive € 3.75m for half of the total costs of € 7.5m. This is an impressive achievement. The state of Hessen supported Goethe University’s application, because high performing computing capacities are essential for Hessen as science location.”

Professor Simone Fulda, Vice President for Research and Academic Infrastructure at Goethe University, states: “Goethe University began the realization of its own high-performance computer centre with significant financial effort many years ago, which was finally able to be built in the Industrial Park Hoechst. It was our good fortune to gain a specialist for supercomputers at Goethe University in the person of Volker Lindenstruth. He developed his own, extraordinarily efficient computer model that is setting standards in this area today and is in demand worldwide. The new Goethe supercomputer clearly continues this development line into the future. We look forward to presenting the completed first construction phase of our new supercomputer to the public on 13^th December on location at the Industrial Park Hoechst.”

Professor Volker Lindenstruth, architect of the “Goethe Supercomputer“ emphasises: “The new Goethe supercomputer represents the fulfilment of a vision. High-performance computing is normally extremely expensive and energy-intensive. Thanks to our particularly efficient construction principle, we were able to decrease energy and operation costs to a minimum. This is particularly good news for increasingly IT-intensive science: we can provide maximum computing performance at costs that only would have been unthinkable just a few years ago.”