Press releases – February 2022

 

Feb 28 2022
13:52

Crystals grown at Goethe University Frankfurt with rare-earth atoms display surprising, fast adjustable magnetic properties.

Spintronics: Innovative crystals for future computer electronics

Computer chips and storage elements are expected to function as quickly as possible and be energy-saving at the same time. Innovative spintronic modules are at an advantage here thanks to their high speed and efficiency, as there is no lossy electrical current, rather the electrons couple with one another magnetically – like a series of tiny magnetic needles which interact with almost no friction loss. A team of scientists involving Goethe University Frankfurt and the Fritz Haber Institute in Berlin has now found promising properties with crystals grown from rare-earth atoms, which offer hope on the long path towards usage as spintronic components.

FRANKFURT. While modern computers are already very fast, they also consume vast amounts of electricity. For some years now a new technology has been much talked about, which although it is still in its infancy could one day revolutionise computer technology – spintronics. The word is a portmanteau meaning “spin” and “electronics”, because with these components electrons no longer flow through computer chips, but the spin of the electrons serves as the information carrier. A team of researchers with staff from Goethe University Frankfurt has now identified materials that have surprisingly fast properties for spintronics. The results have been published in the specialist magazine “Nature Materials”.

“You have to imagine the electron spins as if they were tiny magnetic needles which are attached to the atoms of a crystal lattice and which communicate with one another,” says Cornelius Krellner, Professor for Experimental Physics at Goethe University Frankfurt. How these magnetic needles react with one another fundamentally depends on the properties of the material. To date ferromagnetic materials have been examined in spintronics above all; with these materials – similarly to iron magnets – the magnetic needles prefer to point in one direction. In recent years, however, the focus has been placed on so-called antiferromagnets to a greater degree, because these materials are said to allow for even faster and more efficient switchability than other spintronic materials.

With antiferromagnets the neighbouring magnetic needles always point in opposite directions. If an atomic magnetic needle is pushed in one direction, the neighbouring needle turns to face in the opposite direction. This in turn causes the next but one neighbour to point in the same direction as the first needle again. “As this interplay takes place very quickly and with virtually no friction loss, it offers considerable potential for entirely new forms of electronic componentry,” explains Krellner.

Above all crystals with atoms from the group of rare earths are regarded as interesting candidates for spintronics as these comparatively heavy atoms have strong magnetic moments – chemists call the corresponding states of the electrons 4f orbitals. Among the rare-earth metals – some of which are neither rare nor expensive – are elements such as praseodymium and neodymium, which are also used in magnet technology. The research team has now studied seven materials with differing rare-earth atoms in total, from praseodymium to holmium.

The problem in the development of spintronic materials is that perfectly designed crystals are required for such components as the smallest discrepancies immediately have a negative impact on the overall magnetic order in the material. This is where the expertise in Frankfurt came into play. “The rare earths melt at about 1000 degrees Celsius, but the rhodium that is also needed for the crystal does not melt until about 2000 degrees Celsius,” says Krellner. “This is why customary crystallisation methods do not function here.”

Instead the scientists used hot indium as a solvent. The rare earths, as well as the rhodium and silicon that are required, dissolve in this at about 1500 degrees Celsius. The graphite crucible was kept at this temperature for about a week and then gently cooled. As a result the desired crystals grew in the form of thin disks with an edge length of two to three millimetres. These were then studied by the team with the aid of X-rays produced on the Berlin synchrotron BESSY II and on the Swiss Light Source of the Paul Scherrer Institute in Switzerland.

“The most important finding is that in the crystals which we have grown the rare-earth atoms react magnetically with one another very quickly and that the strength of these reactions can be specifically adjusted through the choice of atoms,” says Krellner. This opens up the path for further optimisation – ultimately spintronics is still purely fundamental research and years away from the production of commercial components.

There are still a great many problems to be solved on the path to market maturity, however. Thus, the crystals – which are produced in blazing heat – only deliver convincing magnetic properties at temperatures of less than minus 170 degrees Celsius. “We suspect that the operating temperatures can be raised significantly by adding iron atoms or similar elements,” says Krellner. “But it remains to be seen whether the magnetic properties are then just as positive.” Thanks to the new results the researchers now have a better idea of where it makes sense to change parameters, however.

Publication: Y. W. Windsor, S.-E. Lee, D. Zahn, V. Borisov, D. Thonig, K. Kliemt, A. Ernst, C. Schüßler-Langeheine, N. Pontius, U. Staub, C. Krellner, D. V. Vyalikh, O. Eriksson, L. Rettig: Exchange scaling of ultrafast angular momentum transfer in 4f antiferromagnets. Nature Materials (2022) https://www.nature.com/articles/s41563-022-01206-4

Further Information:
Prof. Dr. Cornelius Krellner
Crystal and Materials Laboratory
Institute of Physics
Phone: +49 (0)69 798-47295
krellner@physik.uni-frankfurt.de


Editor: Dr. Markus Bernards, Science Editor, PR & Communication Office, Tel: -49 (0) 69 798-12498, Fax: +49 (0) 69 798-763 12531, bernards@em.uni-frankfurt.de  

 

Feb 21 2022
17:01

Important step in filming chemical reactions

Molecule snapshot by explosion

An international team of scientists at the European XFEL has taken a snapshot of a cyclic molecule using a novel imaging method. Researchers from the European XFEL, DESY, Universität Hamburg and the Goethe University Frankfurt and other partners used the world's largest X-ray laser to explode the molecule iodopyridine in order to construct an image of the intact molecule from the resulting fragments. (Nature Physics, DOI 10.1038/s41567-022-01507-0).

SCHENEFELD/FRANKFURT. Exploding a photo subject in order to take its picture? An international research team at the European XFEL, the world's largest X-ray laser, applied this “extreme" method to take pictures of complex molecules. The scientists used the ultra-bright X-ray flashes generated by the facility to take snapshots of gas-phase iodopyridine molecules at atomic resolution. The X-ray laser caused the molecules to explode, and the image was reconstructed from the pieces. “Thanks to the European XFEL's extremely intense and particularly short X-ray pulses, we were able to produce an image of unprecedented clarity for this method and the size of the molecule," reports Rebecca Boll from the European XFEL, principal investigator of the experiment and one of the two first authors of the publication in the scientific journal Nature Physics in which the team describes their results. Such clear images of complex molecules have not been possible using this experimental technique until now.

The images are an important step towards recording molecular movies, which researchers hope to use in the future to observe details of biochemical and chemical reactions or physical changes at high resolution. Such films are expected to stimulate developments in various fields of research. “The method we use is particularly promising for investigating photochemical processes," explains Till Jahnke from the European XFEL and the Goethe University Frankfurt, who is a member of the core team conducting the study. Such processes in which chemical reactions are triggered by light are of great importance both in the laboratory and in nature, for example in photosynthesis and in visual processes in the eye. “The development of molecular movies is fundamental research," Jahnke explains, hoping that “the knowledge gained from them could help us to better understand such processes in the future and develop new ideas for medicine, sustainable energy production and materials research."

In the method known as Coulomb explosion imaging, a high-intensity and ultra-short X-ray laser pulse knocks a large number of electrons out of the molecule. Due to the strong electrostatic repulsion between the remaining, positively charged atoms, the molecule explodes within a few femtoseconds – a millionth of a billionth of a second. The individual ionised fragments then fly apart and are registered by a detector.

"Up to now, Coulomb explosion imaging was limited to small molecules consisting of no more than five atoms," explains Julia Schäfer from the Center for Free-Electron Laser Science (CFEL) at DESY, the other first author of the study. "With our work, we have broken this limit for this method." Iodopyridine (C5H4IN) consists of eleven atoms.

The film studio for the explosive molecule images is the SQS (Small Quantum Systems) instrument at the European XFEL. A COLTRIMS reaction microscope (REMI) developed especially for these types of investigations applies electric fields to direct the charged fragments onto a detector. The location and time of impact of the fragments are determined and then used to reconstruct their momentum – the product of mass and velocity – with which the ions hit the detector. “This information can be used to obtain details about the molecule, and with the help of models, we can reconstruct the course of reactions and processes involved," says DESY researcher Robin Santra, who led the theoretical part of the work.

Coulomb explosion imaging is particularly suitable for tracking very light atoms such as hydrogen in chemical reactions. The technique enables detailed investigations of individual molecules in the gas phase, and is therefore a complementary method for producing molecular movies, alongside those being developed for liquids and solids at other European XFEL instruments.

“We want to understand fundamental photochemical processes in detail. In the gas phase, there is no interference from other molecules or the environment. We can therefore use our technique to study individual, isolated molecules," says Jahnke. Boll adds: “We are working on investigating molecular dynamics as the next step, so that individual images can be combined into a real molecular movie, and have already conducted the first of these experiments."

The investigations involved researchers from Universität Hamburg, the Goethe University Frankfurt, the University of Kassel, Jiao Tong University in Shanghai, Kansas State University, the Max Planck Institutes for Medical Research and for Nuclear Physics, the Fritz Haber Institute of the Max Planck Society, the US accelerator laboratory SLAC, the Hamburg cluster of excellence CUI: Advanced Imaging of Matter, the Center for Free-Electron Laser Science at DESY, DESY and the European XFEL.

Publication: Rebecca Boll, Julia M. Schäfer, et al. X-ray multiphoton-induced Coulomb explosion images complex single molecules. Nature Physics, 2022, https://www.nature.com/articles/s41567-022-01507-0

Picture download:
https://media.xfel.eu/XFELmediabank/?language=en#l=en&cid=26753&cname=Coulomb-Explosion%20(20.01.2022)&f=&s=&p=&r=

Captions:
Model of the molecule Iodopyridine (molecule_A.jpg):
The ring is formed by carbon atoms (grey) and a nitrogen atom (blue). The iodine atom (violet) is on the outside of the ring. Credit: European XFEL / Rebecca Boll, Till Jahnke

Coulomb Explosion Imaging of hydrogen atoms (protons_B.jpg):
In this Coulomb Explosion Imaging result, the scientists have concentrated on the hydrogen atoms (violet). Here the shape of the ring can be seen better because the hydrogen atoms are the first to be emitted from the molecule due to a charge-up of the ring-atoms. The heavier nitrogen atom is emitted later in the process, when more charge has been accumulated. Accordingly, due to larger repulsion its momentum is larger than that of the hydrogen atoms. Credit: European XFEL / Rebecca Boll, Till Jahnke

Coulomb Explosion Image of carbon and nitrogen atoms (Carbons_C.jpg):
The Coulomb Explosion Image of the molecule shows in detail the carbon atoms (red) and the nitrogen atom (green). The ring appears distorted because the detector does not register a direct image but the momentum of the fragments from the explosion, i.e., the product of their mass and velocity. The iodine atom is not displayed as it defines the horizonal axis of the momentum space coordinate system. Credit: European XFEL / Rebecca Boll, Till Jahnke

Further Information:
Professor Till Jahnke
European XFEL and 
Institute for Nuclear Physics, Goethe-University Frankfurt
Phone: + 49 (0)69-798 47023 (Secretary)
till.jahnke@xfel.eu

Rebecca Boll, Ph.D.
European XFEL
Phone: +49 (0)40 8998 6244
Phone: +49 (0)40 8994 1905
rebecca.boll@xfel.de


Editor: Dr. Markus Bernards, Science Editor, PR & Communication Office, Tel: -49 (0) 69 798-12498, Fax: +49 (0) 69 798-763 12531, bernards@em.uni-frankfurt.de

 

Feb 15 2022
11:12

Researchers at Goethe University are studying the auditory perception of bats

How the brain filters out sounds

Whenever bats use echolocation when foraging for food or to communicate with other bats: sounds are omnipresent. How Seba's short-tailed bat, a species native to South America, filters out important signals from the wide diversity of ambient sound is being examined by researchers at the Institute of Cell Biology and Neuroscience at Goethe University Frankfurt. The most recent finding: the brain stem, which to date had been regarded as being solely responsible for very basic tasks, already processes the probabilities of acoustic signals.

FRANKFURT. Bats are renowned for their echolocation skills, navigation using sound therefore: they 'see' with their extremely sensitive hearing, by emitting ultrasonic calls and forming a picture of their immediate environment on the basis of the reflected sound. Thus, for instance, Seba's short-tailed bat (Carollia perspicillata) finds the fruit it prefers to eat using this echolocation system. At the same time bats use their voice to communicate with other bats, whereby they then utilise a somewhat lower frequency range. Seba's short-tailed bat has a vocal range which is otherwise only found among songbirds and humans. Just like humans it creates sound via its larynx.

In order to find out how Seba's short-tailed bat filters out particularly important signals from the wide diversity of different sounds – warning cries from other bats, the isolation calls of infant bats, as well as the reflections from pepper plants in the labyrinth of leaves and branches, for example – researchers at Goethe University Frankfurt recorded the brain waves of the bats.

To this end the researchers headed by Professor Manfred Kössl from the Institute of Cell Biology and Neuroscience inserted electrodes – as fine as acupuncture needles – under the scalp of the bats while the bats drowsed under anaesthetic. Ultimately this measuring method is so sensitive that even the slightest movement of a bat's head would interfere with the results of the measurements. Despite being anaesthetised, the bat's brain still reacts to sound.

Successions of two notes with differing pitches, corresponding to either echolocation calls or communication calls, were then played back to the bats. Initially a sequence was played back in which note 1 occurs much more frequently than note 2, for example “1-1-1-1-2-1-1-1-2-1-1-1-1-1-1...". This was reversed in the next sequence, with note 1 occurring rarely and note 2 frequently. In this manner the scientists wanted to establish whether the neuronal processing of a given sound depended on the probability of it occurring and not, for instance, on its pitch.

Ph.D. student Johannes Wetekam, lead author of the study, explains: “Indeed our research results show that a rare and thus unexpected sound leads to a stronger neuronal response than a frequent sound." In this respect the bat's brain regulates the strength of the neuronal response to frequent echolocation calls by downplaying these, and amplifies the response to infrequent communication calls. Wetekam: “This shows that the bats process unexpected sounds differently in dependence on their frequency in order to gather adequate sensory impressions."

The interesting aspect here, says Wetekam, is that the processing of the signals seemingly already occurs in the brain stem, which it has been assumed to date merely receives acoustic signals and transmits them to higher regions of the brain, where the signals are then offset against one another. The reason: “This probably saves the brain as a whole a lot of energy and allows for a very fast reaction," says Wetekam.

Professor Manfred Kössl believes: “We are all familiar with the party effect: we filter out the conversations of people in our immediate environment so we can concentrate totally on the person we are speaking with. These mechanisms are similar to those found in bats. If we can better understand how bats hear sound, in the future this could help us to understand what occurs with disorders such as ADHD (attention deficit hyperactivity disorder), which disrupt adequate processing of extraneous stimuli."

Publication: Johannes Wetekam, Julio Hechavarría, Luciana López-Jury, Manfred Kössl: Correlates of deviance detection in auditory brainstem responses of bats. Eur. J. Neurosci 2021, Nov 11 https://onlinelibrary.wiley.com/doi/10.1111/ejn.15527

Picture download: https://www.uni-frankfurt.de/112837573

Caption: Searching for fruit at night: Seba's short-tailed bat (Carollia perspicillata). Photo: Julio Hechavarría

Further Information:
Johannes Wetekam
Department of  Neurobiology and Biosensors
Phone +49 (0)69 798 42066
wetekam@bio.uni-frankfurt.de

Professor Manfred Kössl
Institute of Cell Biology and Neuroscience
Head of Department of Neurobiology and Biosensors
Goethe University Frankfurt, Germany
Phone. +49 (0)69 798 42052
Koessl@bio.uni-frankfurt.de
https://www.goethe-university-frankfurt.de/47091958/Department_of_Neurobiology_and_Biosensors


Editor: Dr. Markus Bernards, Science Editor, PR & Communication Office, Tel: +49 (0) 69 798-12498, Fax: +49 (0) 69 798-763 12531, bernards@em.uni-frankfurt.de.

 

With the early assessment of sustainable, newly developed chemicals and products it is possible to assess a potential risk of toxic substances being released at a later point in product cascades. This has been revealed in a proof-of-concept study jointly coordinated by Goethe University Frankfurt and RWTH Aachen University. In the course of the study the toxicity of sustainable biosurfactants, potentially applied in, e.g., bio-shampoos, and of a new technology for the economical deployment of plant protection agents were analysed using a combination of computer modelling and laboratory experiments. The study is the first step towards a safe bioeconomy from an eco-toxicological stance, and which uses sustainable resources and processes to reduce environmental burdens significantly.

FRANKFURT. The natural resources of the planet are running short, yet at the same time they are the basis for our prosperity and development. A dilemma which the EU intends to overcome with the aid of its revised bioeconomy strategy. Rather than relying on fossil-based materials, the economy is to be based on renewable materials. These include plants, wood, microorganisms and algae. At some point in time everything is to be found in closed loops, yet the implementation of a circular bioeconomy requires a shift in the manufacture of chemicals. These also have to be produced from bio-materials rather than crude oil. Based on these requirements the American chemists Paul Anastas and John C. Warner formulated their twelve principles of green chemistry in 1998. One of their principles has very much been neglected to date, however: the reduction of the environmental toxicity of newly developed substances.

It is precisely here that the interdisciplinary project “GreenToxiConomy", which is part of the scientific alliance Bioeconomy Science Center (BioSC), comes into play. The objective was to examine bio-based substances and innovative technologies with a view to their toxic impact on the environment at an early stage in product development and to incorporate the resulting findings into product design. Project partners from Aachen, Jülich and Düsseldorf provided two of their bio-based product candidates for the analyses: microgel containers for crop protection agents and biosurfactants.

The wash-active biosurfactants for use in shampoos and detergents at BioSC are based on the synthesis abilities of the Pseudomonas putida bacterium and the Ustilago maydis fungus, respectively, rather than on crude oil. The microgel technology allows for the controlled delivery of crop protection agents because the containers ensure that the active ingredients still adhere to the plants in the event of rain.

Dr. Sarah Johann, the lead author for the study and the head of a working group in the department of evolutionary ecology and environmental toxicology at the Institute for Ecology, Evolution and Diversity at Goethe University Frankfurt, explains: “For the analysis of novel substances and technologies we have selected a broad range of concentration to be able to adequately estimate potential hazards for humans and the environment. We wanted to examine whether the bio-based surfactants were more environmentally friendly than conventional chemical surfactants. In addition, we investigated whether the microgel containers per se induce any toxicity."

To ensure the ecotoxicological evaluation was as precise as possible, the project team combined two elements in the determination of the toxicity: computer-aided prognoses (in silico) and experiments in the laboratory (in vitro and in vivo). The computer models work with the toxicity data of known chemicals, whose structure they compared with the structure of the new bio-based substances to forecast the toxicity. The experiments were conducted on aquatic and terrestrial organisms that represent specific organism groups, among them earthworms, springtails, water fleas and zebrafish embryos at a very early stage.

The result: both biosurfactants and microgels are highly promising candidates for use in a future bioeconomy whose products must be sustainably manufactured while not causing any environmental damage or harm to humans both during and after their utilisation. “We can only make statements within certain limits, however, as the transfer of laboratory results to the reality in the open field or in other applications is complicated," says Johann. More research is necessary for a holistic assessment of the risk potential, which is why follow-up projects are planned.

Prof. Henner Hollert, head of the evolutionary ecology and environmental toxicology department at Goethe University Frankfurt, underlines the significance of the close interdisciplinary collaboration on “GreenToxiConomy". In the project biotechnologists and engineers jointly designed a new product, and this was evaluated during the development stages by eco-toxicologists from Goethe University together with a team at RWTH Aachen headed by Prof. Dr. Martina Roß-Nickoll. “This continuous process is the major strength of the project." Although it is only a first step towards a bioeconomy that is safe in eco-toxicological terms, for Hollert it is already clear that eco-toxicology and green toxicology will play a key role in the plans being drawn up by the EU. “Whenever it is a question of future bio-based product development and product design, we have to clarify the consequences for humans and the environment at an early stage. In this respect our approach can provide valuable results."

Publication: Sarah Johann, Fabian G. Weichert, Lukas Schröer, Lucas Stratemann, Christoph Kämpfer, Thomas-Benjamin Seiler, Sebastian Heger, Alexander Töpel, Tim Sassmann, Andrij Pich, Felix Jakob, Ulrich Schwaneberg, Peter Stoffels, Magnus Philipp, Marius Terfrüchte, Anita Loeschcke, Kerstin Schipper, Michael Feldbrügge, Nina Ihling, Jochen Büchs, Isabel Bator, Till Tiso, Lars M. Blank, Martina Roß-Nickoll, Henner Hollert. A plea for the integration of Green Toxicology in sustainable bioeconomy strategies – Biosurfactants and microgel-based pesticide release systems as examples. In: J. Hazard. Mat. 426 (2022) 127800. https://doi.org/10.1016/j.jhazmat.2021.127800

Further Information:
Prof. Dr. Henner Hollert
Institute of Ecology, Diversity and Evolution
Goethe University Frankfurt
Phone: +49 (0)69 798-42171
hollert@bio.uni-frankfurt.de
https://www.bio.uni-frankfurt.de/43970666/Abt__Hollert


Editor: Dr. Markus Bernards, Science Editor, PR & Communication Office, Tel: -49 (0) 69 798-12498, Fax: +49 (0) 69 798-763 12531, bernards@em.uni-frankfurt.de  

 

Feb 11 2022
11:45

Nationwide longitudinal study in Germany investigated 250 million hospital admissions

Hospital admission with liver cirrhosis: highest mortality rate of all chronic diseases

In Germany, liver cirrhosis has the highest mortality rate of any chronic disease requiring hospital admission. When diagnosed as a comorbidity of other chronic diseases, liver cirrhosis at least doubles the mortality rate. Overall, the number of patients hospitalised with liver cirrhosis has increased throughout Germany despite the introduction of very effective drugs for treating hepatitis C, and alcohol abuse remains by far the most common cause. These are the results of a study headed by Prof. Jonel Trebicka at the University Hospital Frankfurt, which observed patients over a period of 14 years.

FRANKFURT. Cirrhosis, a disease of the liver in which tissue becomes dysfunctional and scarred, is the final stage of most chronic liver diseases and the fourth most frequent cause of death in central Europe. However, until now hardly any current findings have been available on its epidemiological profile in Germany. For this reason, Prof. Jonel Trebicka and his team of researchers investigated the data sets from the German Federal Statistical Office on the approx. 250 million hospital admissions taking place from 2005 to 2018 in Germany for any reason, and categorised them according to the Tenth Revision of the International Classification of Diseases (ICD-10). They found that 0.94 per cent of these hospitalised patients had been diagnosed with cirrhosis of the liver, which in the majority of cases occurred as a comorbidity and not the primary disease. In absolute figures, admissions of patients with liver cirrhosis rose from 151,108 to 181,688 during the observation period.

The primary end point of the study was the mortality rate from liver cirrhosis in hospital. This did indeed exhibit a welcome fall from 11.57% to 9.49% during the investigation period, but it is still much higher than the respective rates for other chronic diseases such as cardiac insufficiency (8.4%), renal failure (6.4%) and chronic obstructive pulmonary disease (5.2%). In cases where liver cirrhosis was comorbid with another chronic disease, it increased that disease's mortality rate two to three fold; the greatest effect was observed with infectious respiratory diseases.

Thanks to the introduction of direct-acting antivirals to combat Hepatitis C, the proportion of HCV-related cirrhosis fell during the observation period to around one third. On the other hand, the frequency of cirrhosis caused by non-alcoholic fatty liver disease quadrupled during the same period, in parallel with a rise in the number of obese patients. However, despite these etiological trends, cirrhosis caused by alcohol abuse continues to dominate. It accounts for 52 per cent of all cirrhoses in the study, and the absolute number is still rising.

Gastrointestinal bleeding is becoming increasingly rare as a complication of liver cirrhosis in hospital patients, presumably due to the treatment guidelines that continue to be applied in German hospitals, including endoscopic procedures or the administration of non-selective beta blockers. By 2018, bleeding from oesophageal varices had shrunk to one tenth of its original level in 2005. On the other hand, deterioration of symptoms owing to ascites or hepatic encephalopathy caused by insufficient detoxification by the liver has increased. The number of portal vein thromboses doubled in parallel with the intensified use of imaging diagnostics.

The patients admitted with cirrhosis were much younger than those with other chronic diseases: half of them were under the age of 64. Higher hospitalisation rates and in-hospital mortality rates were recorded in the eastern German states than in western Germany. Across the country, around two thirds of patients hospitalised with liver cirrhosis were men. Many of them died while in their fifties or younger, which explains the large number of disability-adjusted life years and the enormous socio-economic burden caused by liver cirrhosis, as men in this age group still account for the majority of the labour force.

“The results of our study show that the decision-makers and financing bodies in the health system should invest much more in the prevention of alcohol-related liver cirrhosis," Prof. Jonel Trebicka concludes. “They also point up how important it is to recognise and treat liver cirrhosis as a comorbidity of other chronic diseases."

Publication: Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Frank E. Uschner, Philip Ferstl, Martin Schulz, Kai-Henrik Peiffer, Alexander Queck, Tilman Sauerbruch, Maximilian Joseph Brol, Gernot Rohde, Cristina Sanchez, Richard Moreau, Vicente Arroyo, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka: Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018) The Lancet Regional Health - Europe 2022;12: 100240 https://doi.org/10.1016/j.lanepe.2021.100240

Further information
Professor Jonel Trebicka
Section Translational Hepatology
Medical Clinic I
Goethe University/University Hospital Frankfurt
Tel. +49 69 6301 80789 (Jennifer Biondo, secretarial office)
Jonel.Trebicka@kgu.de

Editor: Dr Markus Bernards, Science Editor, PR & Communication Department, tel. +49 (0)69 798 12498, fax +49 (0)69 798 76312531, bernards@em.uni-frankfurt.de