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Mission Statement
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The Molecular & Translational Medicine Profile Area stands for excellent research in the fields of cardiology, oncology, neuroscience and drug research. The goal of the Profile Area's council is to advise and support Goethe University with respect to the Profile Area's strategic design to further strengthen it in the coming years, especially with regard to the excellence strategy. The main focus lies on connecting scientists in the Profile Area, initiating research alliances, advising on the content-related orientation and strategically relevant recruitment of excellent researchers, as well as promoting young researchers.
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Profile Area Spokespersons
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The Profile Area 'Molecular and Translational Medicine' brings together basic researchers with physicians and computer scientists to develop new diagnostic and therapeutic strategies. We focus on the topics of cardiac cycle, tumor, and neuroscience, which are backed by a strong drug research network. We intend to further strengthen the Profile Area through the development of new cross-sectional topics and the targeted support and integration of excellent junior scientists.
Stefanie Dimmeler (Cardiovascular Regeneration),
Spokesperson of the Molecular & Translational Medicine Profile Area
Thomas Oellerich (Hematology/Medical Oncology),
Spokesperson of the Molecular & Translational Medicine Profile Area
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Key Research Areas
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The profile area "Molecular & Translational Medicine" is characterized by a close interlinking of basic research and clinical application from the perspective of translational research and reverse translation. The profile area is supported by outstanding individual researchers, including Leibniz Prize winners and several ERC grantees (see "Distinguished Individual Researchers" below) and several research networks (see "Coordinated Research Projects" below). The Cluster of Excellence "Cardio-Pulmonary Institute" (CPI) is currently preparing an application for a continuation of funding as part of the Excellence Strategy. The profile area as a whole currently focuses on the following key research areas:
Cardiovascular Research
Cancer research
Neuroscience
Drug research
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Coordinated Research Projects
DFG (German Research Foundation)
- CRC 1039 "Signalling by fatty acid Derivatives and Sphingolipids in Health and Disease"
- CRC 1177 "Molecular and functional Characterisation of selective Autophagy"
- CRC 1531 "Damage Control by the stroma-vascular Compartment"
- CRC/TRR 267 "Caridovascular ncRNA - Non-coding RNA in the Cardiovascular System" (with TU Munich)
- FOR 2438 "Cell Plasticity in Colorectal Carcinogenesis"
- FOR 5417 "Translational Polytrauma Research to provide diagnostic and therapeutic Tools for improving Outcomes"
- FOR 5643 "HERZBLUT - Clonal Hematopoiesis: Pathomechanisms and Clinical Consequences in the Heart and Blood"
- RTG 2336 "AVE - Resolution of Inflammation"
Associations
- CRC/TRR 219 "Mechanisms of Cardiovascular Complications in Chronic Kidney Disease" (RWTH Aachen)
- CRC/TRR 379 "Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders" (RWTH Aachen)
- CRC/TRR 387 "UbiQancer - Functionalizing the Ubiquitin System against Cancer" (TU Munich)
- CRC 1292 "Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections" (Mainz University)
- CRC 1361 "Regulation of DNA repair and genome stability" (Mainz University)
- CRC 1366 "Vascular Control of Organ Function" (Heidelberg University)
- CRC 1399 "Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer (Cologne University)
- CRC 1425 "Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications" (University of Freiburg)
- CRC 1430 "Molecular Mechanisms of Cell State Transitions" (University of Duisburg/Essen)
- CRC 1479 "OncoEscape - Oncogene-driven immune escape" (University of Freiburg)
- CRC 1530 "Elucidation and targeting of pathogenic mechanisms in B cell malignancies" (Cologne University)
- FOR 2625 "Mechanisms of Lysosomal Homeostasis" (University Medical Center Hamburg-Eppendorf)
HMWK (Hessian Ministry of Higher Education, Research, Science and the Arts)
- RMU Research Cluster "EMTHERA - Emerging Therapeutic Strategies against Infections, Inflammation and Impaired Immune Mechanisms"
- Innovation Center "TheraNova - Innovative Therapeutica"
- LOEWE-Center "FCI - Frankfurt Cancer Institute"
- LOEWE-Center "DYNAMIC – Dynamic Network Approach of Mental Health to Stimulate Innovations for Change"
- LOEWE-Research Cluster "ACLF-I - Pathogenetic mechanisms of acute-on-chronic liver failure and therapeutic approaches"
- LOEWE-Research Cluster "CARISMa - Optimization of CAR cell therapies by influencing the immunosuppressive tumor microenvironment" (as of 01/2025)
Associations
- LOEWE-Center "DRUID - Novel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases" (Marburg)
- LOEWE-Center "TBG - Translational Biodiversity Genomics" (Senckenberg)
- LOEWE-Research Cluster "TRABITA - Transient Binding Pockets for Research and Development" (TU Darmstadt)
- LOEWE-Research Cluster "GLUE - G protein-coupled receptor Ligands for Underexplored Epitopes" (Marburg)
- LOEWE-Research Cluster "CoroPan - Human and zoonotic coronaviruses: conserved targets for new therapeutic options in future pandemics" (Gießen)
BMBF (Federal Ministry of Education and Reseach)
- Advanced Clinician Scientist (ACS) Programm "INITIALISE - Innovations in Infection Medicine" (German link only)
- Cluster4Future "PROXIDRUGS - Innovative Therapies for human diseases:Targeted degradation as a new mode of action for Drugs
- DZHK/German Centre for Cardiovascular Research - Site Rhein-Main
- DKTK/German Cancer Consortium - Site Frankfurt/Mainz
Association
- "NUM - National Network of University Medicine in the Fight against COVID-19 (German link only)
- "R2D2-MH - Risk and Resilience in Developmental Diversity and Mental Health" (Institut Pasteur, F)
Deutsche Krebshilfe (German Cancer Aid)
- UCT - University Cancer Center Frankfurt-Marburg
- MSNZ - Mildred Scheel Career Center Frankfurt
- "TACTIC - Oncogenic transcription as a target structure for new cancer therapies"
- "CAR Factory - a high-performance platform for the development of genetically optimized CAR-T and NK cell therapies against cancer" (German press release)
Others
- ERA-NET NEURON "DynAMoND: Dynamics of Affect Modulation in Neurodevelopmental Disorders" (Institut Pasteur, F)
Distinguished Individual Researchers
ERC-Grants
- Starting Grant "COVIDecode - Interrogating RNA-protein interactions underlying SARS-CoV-2 infection and antiviral defense" (Mathias Munschauer, FB 16)
- Consolidator Grant "AutoXitus - Molecular mechanisms and non-cell autonomous signalling" (Christian Münch, FB 16)
- Consolidator Grant „TRANSCEND - Translational specialization of cellular identity in embryonic development and disease" (Leo Kurian, FB 16)
- Advanced Grant "Neuroheart - The cardiac neurovascular interface in aging" (Stefanie Dimmeler, FB 16)
- Advanced Grant "ER-REMODEL - Endoplasmic reticulum remodelling via ER-phagy pathways" (Ivan Đikić, FB 16)
- Advanced Grant "CHIP-AVS - Clonal hematopoesis of indeterminate potential and degenerative aortic valve stenosis" (Andreas Zeiher, FB 16)
- Advanced Grant "PLASTICAN - Cell Plasticity in Metastatic Colorectal Cancer" (Florian Greten, FB 16; awarded via Georg-Speyer-Haus)
LOEWE Top Professorship
- "Medical Virology" (Sandra Ciesek, FB 16; German link only)
- "Molecular Systems Medicine" (Christian Münch, FB 16; German link only)
Willy Robert Pitzer Foundation Professorship
- "Molecular virology of human pathogenic RNA viruses" (Mathias Munschauer, FB 16; German press release)
Lichtenberg Professorship
- Molecular Systems Medicine (Christian Münch, FB 16)
Junior Research Group
- Max Eder Junior Research Group (German Cancer Aid) "Identification and Targeting of Oncogenic Transcriptional Networks in Acute Lymphoblastic Leukemia" (Anjali Cremer, FB16; German link only)
Leibniz Prizes
- 2013, Ivan Đikić (FB 16)
- 2005, Stefanie Dimmeler (FB 16)
Institutions involved
GRADE Centers
Institutions of Goethe University
Cooperating Institutions
Institutes of Non-University Partners
- BI PEI - Paul Ehrlich Institute: Federal Institute for Vaccines and Biomedicines
- Fh ITMP - Fraunhofer Institute for Translational Medicine and Pharmacology
- MPI AE - Max Planck Institute for Empirical Aesthetics
- MPI BR - Max Planck Institute for Brain Research
- (MPI) ESI - Ernst Strüngmann Institute for Neuroscience
- MPI HLR - Max Planck Institute for Heart and Lung Research
- DKFZ - German Cancer Research Center