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Publikationen 2022

  1. Lötsch J, Kringel D, and Ultsch A. Explainable artificial intelligence (XAI) in biomedicine: Making AI decisions trustworthy for physicians and patients. Biomedinformatics 2022, 2(1), 1-17
  2. El-Hindi K, Brachtendorf S, Hartel JC, Oertel S, Birod K, Merz N, Trautmann S, Thomas D, Weigert A, Schäufele TJ, Scholich K, Schiffmann S, Ulshöfer T, Utermöhlen O, and Grösch S. T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model. Int J Mol Sci 2022, 23, 1866
  3. Sisignano M, Gribbon P, and Geisslinger G. Drug Repurposing to target neuroinflammation and sensory neuron-dependent pain. Drugs 2022, Mar;82(4):357-373
  4. Wedel S, Osthues T, Zimmer B, Angioni C, Geisslinger G, and Sisignano M. Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain. Biochem Pharmacol 2022, Apr;198:114953
  5. Malkusch S, Rahm JV, Dietz MS, Heilemann M, Sibarita JB, and Lötsch J. Receptor tyrosine kinase Met ligand-interaction classified via machine learning from single-particle tracking data". Mol Biol Cell 2022, Feb 16;mbcE21100496
  6. Lötsch J, Mustonen L, Harno H, and Kalso E. Machine-learning analysis of serum proteomics in neuropathic pain after nerve injury in breast cancer surgery points at chemokine signaling via SIRT2 regulation. Int J Mol Sci 2022, 23(7), 3488
  7. Miettinen T, Nieminen AI, Mantyselka P, Kalso E, and Lötsch J. Machine learning and pathway analysis-based discovery of metabolomic markers relating to chronic pain phenotypes. Int J Mol Sci 2022, 23(9), 5085; https://doi.org/10.3390/ijms23095085
  8. Dinh, TS, Brueckle MS, González-González AI, Fessler J, Marschall U, Schubert-Zsilavesz M, Gerlach FM, Harder S, van den Akker M, Schubert I, Muth C, the EVITA Study Group. Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. J Pers Med 2022, 12, 69
  9. Lappe V, Dinh TS, Harder S, Brueckle MS, Fessler J, Marschall U, Muth C, Schubert I, on behalf of the EVITA Study Group. Multimedication Guidelines: Assessment of the Size of the Target Group for Medication Review and Description of the Frequency of Their Potential Drug Safety Problems with Routine Data. Pharmacoepidemiology 2022, 1, 12–25
  10. Schubert I, Fessler J, Harder S, Dinh TS, Brueckle MS, Muth C, on behalf of the EVITA Study Group. Multimedication in Family Doctor Practices: The German Evidence-Based Guidelines on Multimedication. Pharmacoepidemiology 2022, 1, 35–48
  11. Ultsch A, and Lötsch J. Euclidean distance-optimized data transformation for cluster analysis in biomedical data (EDOtrans). BMC Bioinformatics 2022 Jun 16;23(1):233
  12. Möller M, Möser CV, Weiß U, and Niederberger E. The Role of AlphaSynuclein in Mouse Models of Acute, Inflammatory and Neuropathic Pain. Cells 2022, 11(12), 1967
  13. Lötsch J, Huster A, and Hummel T. Sorting of odor dilutions is a meaningful addition to assessments of olfactory function as suggested by machine learning based analyses. J Clin Med 2022 (accepted)
  14. Mayer B, Schwan M, Thormann KM, and Graumann PL. Antibiotic Drug screening and Image Characterization Toolbox (A.D.I.C.T.): a robust imaging workflow to monitor antibiotic stress response in bacterial cells in vivo. F1000Research 2022, 10:277
  15. Gunasekera B, Davies C, Blest-Hopley G, Veronese M, Ramsey NF, Bossong MG, Radua J, Bhattacharyya S, Pretzsch C, McAlonan G, Walter C, Lötsch J, Freeman T, Curran V, Battistella G, Fornari E, Filho GB, Crippa JA, Duran F, Zuardi AW. Task-independent Acute Effects of delta-9-tetrahydrocannabinol on Human Brain Function and Its Relationship With Cannabinoid Receptor Gene Expression: A Neuroimaging Meta-regression Analysis. Neurosci Biobehav Rev 2022 Jul 29;104801
  16. Lötsch J, Ultsch A, Mayer B, and Kringel D. Artificial intelligence and machine learning in pain research: a data-scientometric analysis. Pain Reports 2022 (accepted)
  17. Kratz D, Wilken-Schmitz A, Sens A, Hahnefeld L, Scholich K, Geisslinger G, Gurke R, and Thomas D. Post-mortem changes of prostanoid concentrations in tissues of mice: Impact of fast cervical dislocation and dissection delay. Prostaglandins Other Lipid Mediat 2022 Jun 14;162
  18. Shin J, Kovacheva L, Thomas D, Stojanovic S, Knowlton CJ, Mankel J, Boehm J, Farassat N, Paladini C, Striessnig J, Canavier CC, Geisslinger G, and Roeper J. Cav1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons. Sci Adv 2022 Jun 10;8(23)
  19. Nieraad H, de Bruin N, Arne O, Hofmann MCJ, Pannwitz N, Resch E, Luckhardt S, Schneider AK, Trautmann S, Schreiber Y, Gurke R, Parnham MJ, Till U, and Geisslinger G. The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the AppNL-G-F Model of Alzheimer's Disease. Front Aging Neurosci 2022 Apr 26;14
  20. Hahnefeld L, Vogel A, Gurke R, Geisslinger G, Schäfer MKE, and Tegeder I. Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice. Biomedicines 2022 Apr 15;10(4)
  21. Malacarne PF, Ratiu C, Gajos-Draus A, Müller N, Lopez M, Pflüger-Müller B, Ding X, Warwick T, Oo J, Siragusa M, Angioni C, Günther S, Weigert A, Geisslinger G, Lütjohann D, Schunck WH, Fleming I, Brandes RP, and Rezende F. Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice. Hypertension 2022 Jun;79(6):1216-1226
  22. Schebb NH, Kühn H, Kahnt AS, Rund KM, O'Donnell VB, Flamand N, Peters-Golden M, Jakobsson PJ, Weylandt KH, Rohwer N, Murphy RC, Geisslinger G, FitzGerald GA, Hanson J, Dahlgren C, Alnouri MW, Offermanns S, and Steinhilber D. Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? Front Pharmacol 2022 Mar 2;13:838782
  23. Krybus M, Sieradzki M, Fahimi E, Metry S, Nüsing R, Geisslinger G, Steiner I, Daldrup T, Lehr M, and Kojda G. Contribution of cyclooxygenase-1-dependent prostacyclin synthesis to bradykinin-induced dermal extravasation. Biomed Pharmacother 2022 Apr;148:112786
  24. Roser LA, Erkoc P, Ingelfinger R, Henke M, Ulshöfer T, Schneider AK, Laux V, Geisslinger G, Schmitt I, Fürst R, and Schiffmann S. Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells. Biomed Pharmacother 2022 Apr;148:112734
  25. Kahnt AS, Angioni C, Göbel T, Hofmann B, Roos J, Steinbrink SD, Rörsch F, Thomas D, Geisslinger G, Zacharowski K, Grösch S, Steinhilber D, and Maier TJ. Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport. Front Pharmacol 2022 Jan 21;12:782584
  26. Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Reports 2022 Feb 8;17(2):307-320
  27. Königs V, Pierre S, Schicht M, Welss J, Hahnefeld L, Rimola V, Lütjen-Drecoll E, Geisslinger G, and Scholich K. GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression. Diabetes 2022 Apr 1;71(4):774-787
  28. Kratz D, Sens A, Schäfer SMG, Hahnefeld L, Geisslinger G, Thomas D, and Gurke R. Pre-analytical challenges for the quantification of endocannabinoids in human serum. Chromatogr B Analyt Technol Biomed Life Sci 2022 Feb 1;1190:123102
  29. Hartel JC, Merz N, and Grösch S. How sphingolipids affect T cells in the resolution of inflammation. Front. Pharmacol Sept. 2022
  30. Sekar D, Dillmann C, Sirait-Fischer E, Fink AF, Zivkovic A, Baum N, Strack E, Klatt S, Zukunft S, Wallner S, Descot A, Olesch C, da Silva P, von Knethen A, Schmid T, Grösch S, Savai R, Ferreirós N, Fleming I, Ghosh S, Rothlin CV, Stark H, Medyouf H, Brüne B, and Weigert A. Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. Cancer Res 2022 Apr 15;82(8):1617-1632
  31. Wedel S, Mathdoor P, Rauh O, Heymann T, Ciotu CI, Fuhrmann DC, Fischer MJM, Weigert A, DeBruin N, Hausch F, Geisslinger G, and Sisignano M. SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain. J Neuroinflamm 2022 (accepted)
  32. Lötsch J, and Mayer B. A biomedical case study showing that tuning random forests can fundamentally change the interpretation of supervised data structure exploration aimed at knowledge discovery. Biomedinformatics 2022, 2(4), 544-552;
  33. Lötsch J, Malkusch S, and Ultsch A. Comparative assessment of automated algorithms for the separation of one-dimensional Gaussian mixtures. Inform Med Unlocked 2022 (accepted)
  34. Mayer B, Holtrup S, and Graumann PL. A Machine Learning-Empowered Workflow to Discriminate Bacillus subtilis Motility Phenotypes. BioMedInformatics 2022, 2(4), 565-579
  35. Ultsch A, and Lötsch J. Robust classification using posterior probability-threshold computation followed by Voronoi cell-based class assignment circumventing pitfalls of Bayesian analysis of biomedical data. Int J Mol Sci 2022, 23(22), 14081; https://doi.org/10.3390/ijms232214081
  36. Wedel S, Hahnefeld L, Alnouri MW, Offermanns S, Hausch F, Geisslinger G, and Sisignano M. The FKBP51 inhibitor SAFit2 restores the pain relieving C16 dihydroceramide after nerve injury. Int J Mol Sci 2022 Nov 17;23(22):14274. doi: 10.3390/ijms232214274
  37. Lötsch J, and Ultsch A. Enhancing explainable machine learning by reconsidering initially unselected items in feature selection for classification. BioMedInformatics 2022 (accepted)