The chemist and biologist Professor Cesare Montecucco,
of the Department of Biomedical Research at the University of Padua, Italy, had won
the 100,000 euro Paul Ehrlich and Ludwig Darmstaedter Prize 2011 for his
contribution to research in the field of bacterial diseases, including tetanus, botulism,
anthrax and Helicobacter pylori associated diseases. The award was conferred by the
Scientific Board of the Paul Ehrlich Foundation. The Paul Ehrlich and Ludwig
Darmstaedter Prize is among the most prestigious international awards granted in
the Federal Republic of Germany in the field of medicine.
Cesare Montecucco is engaged in research into human diseases caused by different
pathogens of bacterial and animal origin. He has provided important insights in the
molecular pathogenesis of tetanus, botulism, anthrax and gastrointestinal diseases
due to Helicobacter pylori. Major contributions were those regarding the mechanism
of action the neurotoxins that cause botulism and tetanus and tetanus, caused by
the tetanus bacterium Clostridium tetani and characterized by a muscular rigidity
popularly known as “lockjaw." These neurotoxins provided a major evidence that
the SNARE proteins are the core of the nanomachine which mediates
neurotransmitter release at the synapse, and more in general of most events of
vesicle fusion with the target membrane within the cell.
Professor Cesare Montecucco was born in Trento, Italy, in 1947 and studied
chemistry and biology at the University of Padua, Italy, where he is currently
Professor of Pathology and Deputy Director of the Scuola Galileiana. He also did
research at Cambridge University in the UK, in the Dutch city of Utrecht, at the
Institut Pasteur in Paris, France, at the European Molecular Biology Laboratory in
Heidelberg, Germany and at the University of Costa Rica. Professor Montecucco has
published over 250 articles and edited three books. He is a member of the board of
various leading scientific journals and acts within the scientific committees of several
institutes. In addition, he is a member of the European Molecular Biology
Organization, the German Academy of Sciences Leopoldina, the Istituto Veneto di
Scienze Lettere ed Arti, the Academia Europaea and the American Academy of
Microbiology. For his contributions to the field of infectious diseases, Cesare
Montecucco was awarded the Shipley Award of Harvard Medical School in 1993,
the Prize of the Italian Consortium for Biotechnology in 1998, the Prize of the
Deutsche Gesellschaft für Hygiene und Mikrobiologie in 2000, the Prize of the Masi
Foundation for Venetian Civilization in 2003, the Feltrinelli Prize for Medicine in
2004 and the Redi Award of the International Society on Toxinology in 2009.