25. E. J. N. Helfrich, R. Ueoka, M. G. Chevrette, F. Hemmerling, X. Lu, S. Leopold-Messer, A. Y. Burch A., S. E. Lindow, J. Piel, and M. H. Medema. (2021). Evolution of Combinatorial Diversity in Trans-Acyltransferase Polyketide Synthase Assembly Lines Across Bacteria. Nature Communications (accepted).

24. T. T. H. Fukuda, E. J. N. Helfrich, E. Mevers, W. G. P. Melo, E. B. Van Arnam, D. R. Andes, C. R. Currie, M. T. Pupo, J. Clardy. (2021). Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis. ACS Central Science (link).


23. I. E. Ndukwe, X. Wang, N. Lam, K. Ermanis, K. Alexander, M. J. Bertin, G. E. Martin, G. Muir, I. Paterson, R. Britton, J. Goodman, E. J. N. Helfrich, J. Piel, W. Gerwick, R. T. Williamson. (2020). Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical Communications, 56, 7565-7568 (link).

22. M. Rust M., E. J. N. Helfrich, M. F. Freeman, P. Nanudorn, C. M. Field, C. Rückert, T. Kündig, M. J. Page, V. L. Webb, J. Kalinowski, S. Sunagawa, J. Piel (2020). A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli. Proceedings of the National Academy of Sciences of the United States of America, 117 (17) 9508-9518 (link).

21. T. T. H. Fukuda, C. D. Cassilly, J. P. Gerdt, M. T. Henke, E. J. N. Helfrich,* E. Mevers (2020). Research Tales from the Clardy Laboratory: Function-Driven Natural Product Discovery. Journal of Natural Products, 83, 3, 744–755 (link).

20. S. H. Reisberg, Y. Gao, A. S. Walker, E. J. N. Helfrich, J. Clardy, and P. S. Baran (2020). Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A. Science, 367 (6476), 458-463 (link).


19. E. J. N. Helfrich, G.-M. Lin, C. A. Voigt, and J. Clardy (2019). Terpene Biosynthesis: Challenges and Opportunities for Pathway Engineering. Beilstein Journal of Organic Chemistry, 15, 2889–2906 (link).

18. E. Mevers, J. Saurí, E. J. N. Helfrich, M. Henke, K. Barns, T. S. Bugni, D. Andes, C. Currie, and J. Clardy (2019). Pyonitrins A-D: Chimeric antifungal agents produced by Pseudomonas protegens. Journal of the American Chemical Society, 141 (43), 17098–17101 (link).

17. E. J. N. Helfrich, R. Ueoka, A. Dolev, M. Rust, R. A. Meoded, A. Bhushan, R. Costa, M. Gugger, C. Steinbeck, P. Moreno, and J. Piel (2019). Automated structure prediction of trans-acyltransferase polyketide synthase products. Nature Chemical Biology, 15, 813–821 (link).

16. G. Schleyer, N. Shahaf, C. Ziv, Y. Dong, R. A. Meoded, E. J. N. Helfrich, D. Schatz, S. Rosenwasser, I. Rogachev, A. Aharoni, J. Piel, and A. Vardi (2019). In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids. Nature Microbiology, 4, 527–538 (link).


15. E. J. N. Helfrich, C. M. Vogel, F. Ryffel, D. B. Müller, S. I. Probst, M. Schäfer, R. Ueoka, M. Kreuzer, J. Piel and J. A. Vorholt (2018). Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiota. Nature Microbiology, 3, 909–919 (link).

14. R. A. Meoded, R. Ueoka, E. J. N. Helfrich, K. Jensen, N. Magnus, B. Piechulla, and J. Piel (2018) A polyketide synthase component for oxygen insertion into polyketide backbones. Angewandte Chemie International Edition English., 57 (36), 11644-1164 (link).

13. T. Mori, J. K. B. Cahn, M. C. Wilson, R. A. Meoded, V. Wiebach, A. F. C. Martinez, E. J. N. Helfrich, D. Wibberg, S. Dätwyler, R. Keren, A. Lavy, M. Ilan, J. Kalinowski, H. Takeyama, and J. Piel (2018), Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts. Proceedings of the National Academy of Sciences of the United States of America, 115 (8), 1718-1723 (link).


12. G. Lackner, E. E. Peters, E. J. N. Helfrich, and J. Piel(2017). Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. Proceedings of the National Academy of Sciences of the United States of America, 347–356 (link).

11. D. R. M. Smith, A. R. Uria, E. J. N. Helfrich, D. Milbredt, K.-H. van Pée, J. Piel, and R. J. M. Goss (2017). An unusual flavin-dependent halogenase from the metagenome of the marine sponge Theonella swinhoei WA. ACS Chemical Biology, 12, 1281-1287 (link).


10. E. J. N. Helfrich and J. Piel, (2016) Biosynthesis of polyketides by trans-AT polyketide synthases. Natural Product Reports, 33, 231-316 (link).

9. F. Ryffel, E. J. N. Helfrich, P. Kiefer, L. Peyriga, J.-C. Portais, J. Piel, and J. A. Vorholt (2016) Metabolic footprint of epiphytic bacteria on Arabidopsis thaliana leaves. The ISME Journal, 10, 632–643 (link).

8. M. Wang M, J. J. Carver, V. V. Phelan, L. M. Sanchez, N. Garg, Y. Peng, D. D. Nguyen, J. Watrous, […], Helfrich E. J. N., […], P. C. Dorrestein, and N. Bandeira(2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34, 828–837 (link).

7. R. Ueoka, A. R. Uria, S. Reiter, T. Mori, P. Karbaum, E. E. Peters, E. J. N. Helfrich, B. I. Morinaka, M. Gugger, H. Takeyama, S. Matsunaga, and J. Piel (2016). Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms. Nature Chemical Biology, 11, 705–712 (link).


6. M. H. Medema, R. Kottman, P. Yilmaz, M. Cummings, […], E. J. N. Helfrich, […], R. Breitling, E. Takano, and F. O. Glöckner (2015). Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology, 11, 625–631 (link).

5. A. Liaimer,E. J. N. Helfrich, K. Hinrichs, A. Guljamow, K. Ishida, C. Hertweck, and E. Dittmann (2015). Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proceedings of the National Academy of Sciences of the United States of America, 112(6):1862-1867 (link).


4. E. J. N. Helfrich, S. Reiter, and J. Piel (2014). Recent advances in genome-based polyketide discovery. Current Opinion in Biotechnology, 29, 107–15 (link).

3. T. Jaschinski, E. J. N. Helfrich, C. Bock, S. Wolfram, A. Svatoš, C. Hertweck, and G. Pohnert (2014). Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana. Journal of Mass Spectrometry, 49(2), 136–44 (link).


2. M. C. Wilson, T. Mori, C. Rückert, A. R. Uria, M. J. Helf, K. Takada, C. Gerner, U. Steffens, N. Heycke, A. Brachmann, S. Schmitt, C. Rinke, C. Gurgui, E. J. N. Helfrich, T. Wakimoto, M. Kracht, M. Crüsemann, U. Hentschel, I. Abe, S. Matsunaga, J. Kalinowski, H. Takeyama, J. Piel (2013). Discovery of an environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62 (link).


1. R. Teta, M. Gurgui, E. J. N. Helfrich, S. Künne, A. Schneider, G. Van Echten-Deckert, A. Mangoni, and J. Piel (2010). Genome mining reveals trans-AT polyketide synthase directed antibiotic biosynthesis in the bacterial phylum bacteroidetes. ChemBioChem. 11(18):2506-2512 (link).

Prof. Dr. Eric J N Helfrich
Naturstoffgenomik -
Natural Product Genomics
Campus Riedberg
Gebäudeteil 250
Raum 0.04b
Max-von-Laue-Str. 9
60438 Frankfurt am Main 

T +49 69 798 29557
F +49 69 798 42193

Sophie Moktadir
Campus Riedberg
Gebäudeteil 250, Raum 0.04
Max-von-Laue-Str. 9
60438 Frankfurt am Main

T +49 69 798 29558
F +49 69 798 29527