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Publikationen 2014

  1. Meyer dos Santos S, Kuczka K, Picard-Willems B, Nelson K, Klinkhardt U, and Harder S. The integrin antagonist, cilengitide, is a weak inhibitor of αIIbβ3 mediated platelet activation and inhibits platelet adhesion under flow. Platelets 2014 Jan 16. [Epub ahead of print]
  2. Abbas S, Ihle P, Harder S, Schubert I. Risk of bleeding and antibiotic use in patients receiving continuous phenprocoumon therapy – a case-control study nested in a large insurance- and population-based German cohort. Thrombosis and Haemostasis 2014 May 5;111(5):912-22
  3. Schuh CD, Pierre S, Weigert A, Weichand B, Altenrath K, Schreiber Y,  Ferreiros; N, Zhang, DD,  Suo J, Treutlein EM, Henke M, Kunkel H, Grez M, Nüsing RM, Brüne B, Geisslinger G, and Scholich  K. Prostacyclin mediates neuropathic pain through interleukin 1beta-expressing resident macrophages. Pain 2014 Mar;155(3):545-55
  4. Ferreirós N, Labocha S, El-Duweik J, Schlecker C, Lötsch J, and Geisslinger G. Quantitation of ribavirin in human plasma and red blood cells using LC-MS/MS. J Separation Sci 2014 Mar;37(5):476-83
  5. Felden L, Walter C, Angioni C, Schreiber Y, von Hentig N, Ferreirós N, Geisslinger G, and Lötsch J. Similar maximum systemic but not local cyclooxygenase-2 inhibition by 50 mg lumiracoxib and 90 mg etoricoxib. A randomized controlled trial in healthy subjects. Pharm Res 2014 Jan 28. [Epub ahead of print]
  6. Schiffmann S, Weigert A, Männich J, Eberle M, Birod K, Häussler A, Ferreiros N, Schreiber Y, Kunkel H, Grez M, Weichand B, Brüne B, Pfeilschifter W, Nüsing R, Niederberger E, Grösch S, Scholich K and Geisslinger G. PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. Biochem Pharmacol 2014 Feb 15;87(4):625-35
  7. Ultsch A and Lötsch J. Functional abstraction as a method to discover knowledge in gene ontologies. PLoS OneFeb 25;9(2):e90191 2014
  8. Suo J, Linke B, Meyer dos Santos S, Pierre S, Stegner D, Zhang DD, Denis C, Geisslinger G, Nieswandt B, and Scholich K. Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation. J Leukocyte Biol 2014 Feb 20. [Epub ahead of print]
  9. Meyer dos Santos S and Harder S. Benefit-Risk Assessment of Dabigatran in the Treatment of Stroke Prevention in non-valvular Atrial Fibrillation. Drug Safety 2014 May;37(5):295-307
  10. Schütz M, Oertel BG, Heimann D, Doehring A, Walter C, Dimova V, Geisslinger G, and Lötsch J. Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli. PLoS One 2014 Apr 21;9(4):e95592
  11. Sailler S, Schmitz K, Jäger E, Ferreiros N, Wicker S, Zschiebsch K, Pickert G, Geisslinger G, Walter C, Tegeder I, and Lötsch J. Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans. Oncoscience 2014 Volume 1, Issue 4, p272
  12. Walter C, Oertel BG, Ludyga D, Ultsch A, Hummel T, and Lötsch J. Effects of 20 mg oral Delta-9-tetrahydrocannabinol on human olfaction. Br J Clin Pharmacol 2014 May 6. doi: 10.1111/bcp.12415. [Epub ahead of print]
  13. Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KM, Eaton P, Geisslinger G, and  Schmidtko A.  Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury. Antioxid Redox Signal 2014 (Epub ahead of print)
  14. Kallenborn-Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz JE, Lippold N, Real CI, Ferreirós N, Geisslinger G, Del Turco D, and Schmidtko A. Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing. Anesthesiology 2014 (Epub ahead of print)
  15. Russe OQ, Möser CV, Kynast KL, King TS, Olbrich K, Grösch S, Geisslinger G, and Niederberger E. LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochem Biophys Res Commun 2014 May 9;447(3):520-5. doi: 10.1016/j.bbrc.2014.04.008. Epub 2014 Apr 13
  16. Niederberger E. Epigenetics and pain. Anaesthesist. 2014 Jan;63(1):63-9. doi: 10.1007/s00101-013-2274-7
  17. Chan JS, van den Bosch JJF, Theves S, Hardt S, Pflanz P, Lötsch J, Kaiser J, Naumer MJ. Synaesthesia or vivid imagery? A single case fMRI study of visually induced olfactory perception. Multisens Res 2014 (in press)
  18. Juengel E, Nowaz S, Makarevi J, Natsheh I, Werner I, Nelson K, Reiter M, Tsaur I, Mani J, Harder S, Bartsch G, Haferkamp A, Blaheta RA. HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A. Mol Cancer 2014 Jun 16;13(1):152
  19. Walter C, Oertel BG, and Lötsch J. THC may reproducibly induce electrical hyperalgesia in healthy volunteers. Eur J Pain 2014 Jul 28. doi: 10.1002/ejp.575. [Epub ahead of print]
  20. Lötsch J, Oertel BG, and Ultsch A. Human models of pain for the prediction of clinical analgesia. Pain 2014 Jul 11. pii: S0304-3959(14)00319-4. doi: 10.1016/j.pain.2014.07.003. [Epub ahead of print]
  21. Oertel BG, Vermehren J, Huynh TT, Doehring A, Ferreiros N, Zimmermann M, Geisslinger G, and Lötsch J. Cytochrome P450 epoxygenase dependence of opioid analgesia: fluconazole does not interact with remifentanil-mediated analgesia in human subjects. Clin Pharmacol Ther 2014 Aug 22. doi: 10.1038/clpt.2014.169. [Epub ahead of print]
  22. Syhr KM, Kallenborn-Gerhardt W, Lu R, Olbrich K, Schmitz K, Männich J, Ferreiros-Bouzas N, Geisslinger G, Niederberger E, and Schmidtko A. Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice. Pharmacol Biochem Behav 2014 Jul 18;124C:389-395
  23. Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, and Schmidtko A. Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity. Pain 2014 Aug 16 [Epub ahead of print]
  24. Schmitz K, deBruin N, Bishay P, Männich J, Häussler A, Ferreirós N, Lötsch J, Ultsch A, Parnham MJ, Geisslinger G, and Tegeder I. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med 2014 Sep 30. pii: e201404168. doi: 10.15252/emmm.201404168. [Epub ahead of print]
  25. Eberle M, Ebel P, Wegner MS, Männich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, Geisslinger G, Grösch S, and Schiffmann S. Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol  2014 Aug 27 [Epub ahead of print]
  26. Oertel BG, Huynh TT, Hummel T, and Lötsch J. Lack of fluconazole effects on human chemosensation. Int J Clin Pharmacol Ther 2014 (accepted)
  27. Lötsch J and Hummel T. Cannabinoid-related olfactory neuroscience in mice and humans. Chem Senses  2014 Nov 11. pii: bju054. [Epub ahead of print]
  28. Ultsch A and Lötsch J. What do all the (human) micro-RNAs do? A functional genomics perspective. BMC Genomics 2014 Nov 18;15(1):976
  29. Sisignano M, Baron R, Scholich K, and Geisslinger G. Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nat Rev Neurol 2014 (in press)
  30. Bergert FW, Braun M, Ehrenthal K, Feßler J, Gross J, Hüttner U, Kluthe B, Liesenfeld A, Seffrin J, Vetter G, Beyer M, Muth C, Popert U, Harder S, Kirchner H, Schubert I. Recommendations for treating adult and geriatric patients on multimedication. Int J Clin Pharmacol Ther. 2014 Oct;52 Suppl 1:1-64.
  31. Harder S. Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban: considerations for the treatment of venous thromboembolism. Thromb Journal 2014 (in press)
  32. Grammatikos G, Ferreirós N, Bon D, Schwalm S, Dietz J, Berkowski C, Fitting D, Herrmann E, Zeuzem S, Sarrazin C and Pfeilschifter J. Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in HCV but not HBV infection. Hepatology 2014 Oct 28. doi: 10.1002/hep.27587
  33. Pleli T, Martin D, Kronenberger B, Brunner F, Köberle V, Grammatikos G, Farnik H, Martinez Y, Finkelmeier F, Labocha S, Ferreirós N, Zeuzem S, Piiper A and Waidmann O. Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study. PLoS One 2014 Jul 25;9(7):e103532
  34. Sturm EM, Radnai B, Jandl K, Stančić A, Parzmair GP, Högenauer C, Kump P, Wenzl H, Petritsch W, Pieber TR, Schuligoi R, Marsche G, Ferreirós N, Heinemann A and Schicho R. Opposing roles of prostaglandin D2 receptors in ulcerative colitis. J Immunol. 2014 Jul 15;193(2):827-39
  35. Ferreirós N, Homann J, Labocha S, Grossmann N, Hahn JS, Brüne B and Geisslinger G. Lipoxin A₄: problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography. Talanta 2014 Sep;127:82-7
  36. Grammatikos G, Mühle C, Ferreirós N, Schroeter S, Bogdanou D, Schwalm S, Hintereder G, Kornhuber J, Zeuzem S, Sarrazin C and Pfeilschifter J. Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. Biochim Biophys Acta 2014 Jul;1841(7):1012-20
  37. Farnik H, Zimmermann T, Herrmann E, Bechstein WO, Kronenberger B, Galle PR, Labocha S, Ferreirós N, Geisslinger G, Zeuzem S, Sarrazin C and Welker MW. Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. Liver Int 2014 Mar 20. doi: 10.1111/liv.12532
  38. Namgaladze D, Lips S, Leiker TJ, Murphy RC, Ekroos K, Ferreiros N, Geisslinger G and Brüne B. Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses. Diabetologia 2014 May;57(5):1067-77
  39. Kanngiesser M, Mair N, Lim HY, Zschiebsch K, Blees J, Häussler A, Brüne B, Ferreirós N, Kress M and Tegeder I. Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence. Antioxid Redox Signal 2014 Jun 1;20(16):2555-71
  40. Nielsen BN, Friis SM, Rømsing J, Schmiegelow K, Anderson BJ, Ferreirós N, Labocha S and Henneberg SW. Intranasal sufentanil/ketamine analgesia in children. Paediatr Anaesth 2014 Feb;24(2):170-80
  41. Thomas D, Suo J, Ulshöfer T, Jordan H, de Bruin N, Scholich K, Geisslinger G, Ferreirós N. Nano-LC-MS/MS for the quantitation of prostanoids in immune cells. Anal Bioanal Chem 2014 Nov;406(28):7103-16
  42. Guder JC, Buchhaupt M, Huth I, Hannappel A, Ferreirós N, Geisslinger G and Schrader J. Biotechnological approach towards a highly efficient production of natural prostaglandins. Biotechnol Lett 2014 Nov;36(11):2193-8
  43. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP and Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol 2014 Jan;171(2):438-51
  44. Wegner MS, Wanger RA, Oertel S, Brachtendorf S, Hartmann S, Schiffmann S, Marschalek R, Schreiber Y, Ferreirós N, Geisslinger G, Grösch S. Ceramide synthases CerS4 and CerS5 are upregulated by 17b-estradiol and GPER1 via AP-1 in human breast cancer cells. Biochem Pharmacol 2014 (Epub ahead of print)
  45. Lötsch J and Ultsch A. Exploiting the structures of the U-matrix. In: Advances in Intelligent Systems and Computing. Villmann, T., Schleif, F-M., Kaden, M., Lange, M. (eds): Self-Organinzing Maps and learning Vector Quantization, Springer, pp. 248 - 257, 2014 (ISSN 978 3 319 07694 2).
  46. Lötsch J and Ultsch A. Pain in the network of genetic and epigenetic control. Molecular Pain [2014, 10(Suppl 1):O9-O9]