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Publikationen 2017

  1. Bluecher A, Meyer dos Santos S, Ferreirós N, Labocha S, Meyer dos Santos I, Picard-Willems B, Harder S, and Singer OC. Microfluidic coagulation assay for monitoring anticoagulant therapy in acute stroke patients. Thrombosis & Haemostasis 2017 Feb 28;117(3):519-528
  2. Ultsch A and Lötsch J. Machine-learned cluster identification in high-dimensional data. J Biomed Informatics 2017 Feb;66:95-104
  3. Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, and Scholich K. The leukotriene B4 receptors BLT1 and Frontiers in Human NeuroscienceBLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem 2017 Feb 27. pii: jbc.M116.769125. doi: 10.1074/jbc.M116.769125. [Epub ahead of print]
  4. Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, Christen U. Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes. Diabetes 2017 Jan;66(1):113-126
  5. Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, and Scholich K. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. J Invest Dermatol 2017 Mar;137(3):686-695
  6. Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, and Sisignano M. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Scientific Reports 2017 Mar;7-446 ; doi:10.1038/s41598-017-00591-0
  7. Linke B, Schreiber Y, Picard-Willems B, Slattery P,  Nüsing R, Harder S, Geisslinger G, and Scholich K. Activated platelets induce an anti-inflammatory response of monocytes/macrophages through cross-regulation of PGE2 and cytokines. Mediators of Inflammation, accepted
  8. Oertel S, Scholich K, Weigert A, Thomas T, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, and Grösch S. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Science 2017, doi:10.1007/s00018-017-2518-9
  9. Florian P,  Wonerow P,  Harder S, Kuczka K, Dubar M, Graff J. Anti GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber. Eur J Clin Pharmacol May 18. doi: 10.1007/s00228-017-2264-9
  10. Lötsch J, Ultsch A, and Kalso E. Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: Biomarker development with machine-learning-derived analysis. Br J Anaesthesia 2017 aex236
  11. Lötsch J, Thrun M, Lerch F, Brunkhorst R, Schiffmann S, Thomas D, Tegder I, Geisslinger G, and Ultsch A. Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects. Int J Mol Sci 2017 18(6), 1217; doi:10.3390/ijms18061217
  12. Treutlein EM, Zinn S, and Scholich K.  NSAIDS in the light of fever, inflammation and pain. Pharmakon Vol. 5(1), 2017, 14-20
  13. Kern K, Pierre S, Schreiber Y, Angioni C, Thomas D, Ferreirós N, Geisslinger G, and Scholich K. CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages. Prostaglandins and Other Lipid Mediators 2017 Jun 2. pii: S1098-8823(17)30010-2. doi: 10.1016/j.prostaglandins.2017.06.002
  14. Schmitz K, Brunkhorst R, de Bruin N, Mayer C, Ferreiros F, Häussler A, Schiffmann S, Parnham M, Tunaru S, Chun J, Offermanns S, Förch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, and Tegeder I. Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis. Acta Neuropatholog Commun 2017 Jun 2;5(1):42. doi: 10.1186/s40478-017-0446-4
  15. Kringel D, Sisignano M, Zinn S, and Lötsch J. Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq™ panel. PLoS One 2017 Jun 28;12(6):e0180116
  16. Weichand B, Mora J, Popp R, Dziumbla S, Scholich K, Pierre S, Syed SN, Olesch C, Ören B, Döring C, Fleming I, Jung M, von Knethen A, Levkau B, Weigert A, and Brüne B. S1PR1 signaling in a subset of tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β. J Exp Med 2017 Sep 4;214(9):2695-2713
  17. Lötsch J, Geisslinger G, Heinemann S, Lerch F, Oertel BG, and Ultsch A. Quantitative sensory testing response patterns to capsaicin- and UV-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis. Pain Aug 16. doi: 10.1097/j.pain.0000000000001008. [Epub ahead of print]
  18. Linke B, Meyer Dos Santos S, Picard-Willems B, Keese M, Harder S, Geisslinger G, and Scholich K. CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium. Cytokine 2017 Jun 21. pii: S1043-4666(17)30171-0. doi: 10.1016/j.cyto.2017.06.008. [Epub ahead of print]
  19. Ultsch A and Lötsch J. A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions. PLoS One 2017 Aug 10;12(8):e0181572. doi: 10.1371/journal.pone.0181572. eCollection 2017
  20. Heidegger T, Hansen-Goos O, Batleva O, Annak O, Ziemann U, and Lötsch J. A data-driven approach to responder subgroup identification after paired continuous theta burst stimulation. Front Hum Neurosci 2017 Aug 4;11:382. doi: 10.3389/fnhum.2017.00382. eCollection 2017
  21. Niederberger E, Resch E, Parnham MJ, and Geisslinger G. Drugging the pain epigenome. Nat Rev Neurol 2017 Jul;13(7):434-447. doi: 10.1038/nrneurol.2017.68
  22. King-Himmelreich TS, Möser CV, Wolters MC, Schmetzer J, Schreiber Y, Ferreirós N, Russe OQ, Geisslinger G, and Niederberger E. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids. Neuropharmacology 2017 Sep 15;124:134-142
  23. King-Himmelreich TS, Möser CV, Wolters MC, Schmetzer J, Möller M, Schreiber Y, Ferreirós N, Geisslinger G, and Niederberger E. AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice. Mol Pain 2017 Jan;13:1744806917703111. doi: 10.1177/1744806917703111
  24. Lötsch J, Lippmann C, Kringel D, and Ultsch A. Integrated computational analysis of genes associated with human hereditary insensitivity to pain. A drug repurposing perspective. Frontiers Mol Neurosci2017 Aug 8;10:252. doi: 10.3389/fnmol.2017.00252. eCollection 2017
  25. Walter C, Oertel BG, Felden L, Nöth U, Vermehren J, Deichmann R, and Lötsch J. Effects of oral delta9-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects. Eur J Clin Pharmacol 2017 Sep 2. doi: 10.1007/s00228-017-2331-2. [Epub ahead of print]
  26. Lötsch J. Data visualizations to detect systematic errors in laboratory assay results. Pharmacol Res Perspect 2017;e369
  27. Pierre S, Zhang DD, Suo J, Kern K, Tarighi N, and Scholich K. Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice. European Journal of Immunology 2017 (accepted)
  28. Lötsch J, Weyer-Menkhoff I, and Tegeder I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings. Eur J Pain 2017 Nov 24. doi: 10.1097/j.pain.0000000000001118. [Epub ahead of print]
  29. Albi A, Alessenko A, ans Grösch S. Sphingolipids in Inflammation. Editorial, Special Issue: Sphingolipids in Inflammation, Mediators of Inflammation 2017 (in press)
  30. Hasenoehrl C, Feuersinger D, Sturm EM, Bärnthaler T, Heitzer E, Graf R, Grill, M, Pichler M, Beck S, Butcher L, Thomas D, Ferreirós N, Schuligoi R, Schweiger C, Haybaeck J, Schicho R. G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1. Int J Cancer 2018 Jan 1;142(1):121-132. doi: 10.1002/ijc.31030. Epub 2017 Sep 21
  31. Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J. Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. Am J Pathol 2017 Nov;187(11):2413-2429
  32. Schmidt KG, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger FM, Thomas D, Zaucke F, Pfeilschifter JM, Radeke HH. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic  Sclerosis: A Pilot Study. Front Immunol 2017 Sep 29;8:1242
  33. Bärnthaler T, Maric J, Platzer W, Konya V, Theiler A, Hasenöhrl C, Gottschalk B, Trautmann S, Schreiber Y, Graier WF, Schicho R, Marsche G, Olschewski A, Thomas D, Schuligoi R, Heinemann A. The Role of PGE(2) in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk. Sci Rep 2017 Aug 11;7(1):7923
  34. Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, Penna-Martinez M. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci 2017 Jul 15;18(7). pii: E1532. doi: 10.3390/ijms18071532
  35. Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr. Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med 2017 Jun 6;23(6):788
  36. Frölich S, Slattery P, Thomas D, Goren I, Ferreiros N, Jensen BL, Nüsing RM. Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation. Kidney Int 2017 Apr;91(4):818-829
  37. Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med 2017 Feb;23(2):250-255
  38. Kuchler L, Sha LK, Giegerich AK, Knape T, Angioni C, Ferreirós N, Schmidt MV, Weigert A, Brüne B, von Knethen A. Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. Mol Immunol 2017 Oct;90:255-263
  39. Fork C, Vasconez AE, Janetzko P, Angioni C, Schreiber Y, Ferreirós N, Geisslinger G, Leisegang MS, Steinhilber D, Brandes RP. Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300. J Lipid Res 2017 Feb;58(2):386-392
  40. Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Ferreiros Bouzas N, Pfeilschifter J, Devraj K, Pfeilschifter W. Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J Neurochem 2017 Oct 11. doi: 10.1111/jnc.14236. [Epub ahead of print]
  41. Ringleb J, Strack E, Angioni C, Geisslinger G, Steinhilber D, Weigert A, Brüne B. Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages. J Immunol 2017 Dec 11. pii: ji1700609. doi: 10.4049/jimmunol.1700609. [Epub ahead of print]
  42. Schmidt J, Rotter M, Weiser T, Wittmann S, Weizel L, Kaiser A, Heering J, Goebel T, Angioni C, Wurglics M, Paulke A, Geisslinger G, Kahnt A, Steinhilber D, Proschak E, Merk D. A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. J Med Chem 2017 Sep 28;60(18):7703-7724
  43. Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. Antioxid Redox Signal 2017 Sep 8. doi: 10.1089/ars.2017.7155. [Epub ahead of print]
  44. Janas C, Mast MP, Kirsamer L, Angioni C, Gao F, Mäntele W, Dressman J, Wacker MG. The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers. Eur J Pharm Biopharm 2017 Jun;115:73-83
  45. Kretschmer SB, Woltersdorf S, Vogt D, Lillich FF, Rühl M, Karas M, Maucher IV, Roos J, Häfner AK, Kaiser A, Wurglics M, Schubert-Zsilavecz M, Angioni C, Geisslinger G, Stark H, Steinhilber D, Hofmann B. Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles. Biochem Pharmacol 2017 Jan 1;123:52-62