Publikationen/Publications


Original Article/Reviews - Books - Congress Reports

Original Article/Reviews

Hamann A, Osiewacz HD (2022)  To die or not to die - How mitochondrial processes affect lifespan of Podospora anserina. Biochim Biophys Acta Bioenerg 1863: 148568. doi: 10.1016/j.bbabio.2022.148568

Hamann A, Osiewacz HD, Teichert I (2022) Sordaria macrospora sterile mutant pro34 is impaired in respiratory complex I assembly. J Fungi (Basel) 8: 1015. doi: 103390/jof8101015

Kleinwächter I, Mohr B, Joppe A, Hellmann N, Bereau T, Osiewacz HD, Schneider D (2022) CLiB - novel cardiolipin-binder isolated via data-driven in vitro screening. RSC Chem Biol 3: 941-954. doi: 10.1039/d2cb00125j

Marschall LM, Warnsmann V, Meeßen AC, Löser T, Osiewacz HD (2022) Lifespan extension of Podospora anserina Mic60-subcomplex mutants depends on cardiolipin remodeling. Int J Mol Sci 23: 4741. doi: 10.3390/ijms23094741

Schürmanns L, Hamann A, Osiewacz HD (2022)  Lifespan increase of Podospora anserina by oleic acid is linked to alterations in energy metabolism, membrane trafficking and autophagy. Cells 11: 519. doi: 10.3390/cells11030519

Warnsmann V, Marschall LM, Meeßen AC, Wolters M,  Schürmanns L, Basoglu M,  Eimer S, Osiewacz HD (2022) Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina. J Cell Biochem 123: 1306-1326. doi: 10.1002/jcb.30278

Heinz D, Krotova E, Hamann A, Osiewacz HD (2021) Simultaneous ablation of the catalytic AMPK α-subunit SNF1 and mitochondrial matrix protease CLPP results in pronounced lifespan extension. Front Cell Dev Biol 9: 616520 (doi:10.3389/fcell.2021.616520)

Klionsky DJ et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17: 1-382 (doi: 10.1080/1554 8627.2020.1797280)

Löser T, Joppe A, Hamann A, Osiewacz HD (2021) Mitochondrial phospholipid homeostasis is regulated by the i-AAA protease PaIAP and affects organismic aging. Cells 10: 2775 (doi:10.3390/cells10102775)

Osiewacz HD, Schürmanns L (2021) A network of pathways controlling cellular homeostasis affects the onset of senescence in Podospora anserina. J Fungi 7: 263 (doi: 10.3390/jof7040263)

Warnsmann V, Marschall LM, Osiewacz HD (2021) Impaired F1F0-ATP-synthase dimerization leads to the induction of cyclophilin D-mediated autophagy-dependent cell death and accelerated aging. Cells 10: 757 (doi: 10.3390/ cells10040757)

Warnsmann V, Meisterknecht J, Wittig I, Osiewacz HD (2021) Aging of Podospora anserina leads to alterations of OXPHOS and the induction of non-mitochondrial salvage pathways. Cells 10: 3319. doi: 10.3390/cells10123319

Gnaiger E et al. (2020) Mitochondrial physiology. Bioenerg Commun 1: 1-44 (doi:10.26124/bec:2020-0001.v1)

Henkel V, Schürmanns L, Brunner M, Hamann A, Osiewacz HD (2020) Role  of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina. Mech Ageing Dev 186: 111211 (doi: 10.1016/j.mad.2020.111211)

Koch I, Philipp O, Hamann A, Osiewacz HD (2020) Reconstruction of protein-protein interaction networks using homology-based search: Application to the autophagy pathway of aging in Podospora anserina. Methods Mol Biol 2074: 45-55 (doi: 10.1007/978-1-4939-9873-9_4)

Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi JC, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, Van der Horn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV (2020)  Classification and  nomenclature of metacaspases and paracaspases: No more confusion with caspases. Mol Cell 77: 927-929 (doi: 10.1016/j.molcel.2019.12.020)

Nguyen TD, Shaid S, Vakhrusheva O, Koshade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH (2019) Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. BLOOD 133: 168-179, (doi:10.1182/blood-2018-02-833475)

Carmona-Gutierrez D et al. (2018) Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell 5: 4-35 (doi: 10.15698/mic2018.01.607)

Hamann A, Osiewacz HD (2018) Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging. In: Ram JL, Conn M (eds) Handbook of models on human aging, 2nd Ed., Elsevier, pp 431-444

Meyer N, Zielke S, Michaelis JB, Lindner B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D (2018) AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 14: 1693-1709 (doi: 10.1080/15548627.2018.1476812)

Rampello NG, Strenger M, Westermann B, Osiewacz HD (2018) Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging. Microbial Cell 5: 198-207 (doi:10.15698/mic2018.04.625)

Warnsmann V, Hainbuch S, Osiewacz HD (2018) Quercetin-induced lifespan extension in Podospora anserina requires methylation of the flavonoid by the O-methyltransferase PaMTH1. Front Genet 9: 160 (doi: 10.3389/fgene.2018.00160)

Boilan E, Winant V, Dumortier E, ElMoualij B, Quatresooz P, Osiewacz HD, Debacq-Chainiaux, Toussaint O (2017) Role of prion protein in premature senescence of human fibroblasts. Mech Aging Dev 170: 106-113 (doi: 10.1016/j.mad.2017.08.002)

Henkel V, Warnsmann V, Osiewacz HD (2017) Autophagic responses compensate mitochondrial impairments. Aging 9: 1947-1948 (doi: 10.18632/aging.101292)

Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP deficient Podospora anserina strains and extends healthspan. Aging Cell 16: 704-715 (doi: 10.1111/acel.1260)

Knuppertz L, Warnsmann V, Hamann A, Grimm C, Osiewacz HD (2017) Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina. Autophagy 13: 1037-1052 (doi: 10.1080/15548627.2017.1303021)

Pampaloni F, Knuppertz L, Hamann A, Osiewacz HD, Stelzer EH (2017) Three-dimensial live imaging of filamentous fungi with light sheet-based fluorescence microscopy (LSM). Methods Mol Biol 1563:19-31 (doi: 10.1007/978-1-4939-6810-7-2)

Philipp O, Hamann A, Osiewacz HD, Koch I (2017) The autophagy interaction network of the aging model Podospora anserina. BMC Bioinformatics 18: 196 (doi: 10.1186/s12859-017-1603-2)

Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD (2017) A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Aging Dev 170: 45-58 (doi: 10.1016./j.mad2017/06.004)

Klionsky DJ et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222. (doi:10.1080/15548627.2015. 1100356)

Knuppertz L, Osiewacz HD (2016) Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy. Mech Ageing Dev 153: 30-40 (doi: 10.1016/j.mad.2016.01.003)

Kramer P, Jung A, Hamann A, Osiewacz HD (2016) Cyclophilin D is involved in the regulation of autophagy and affects the lifespan of P. anserina in response to mitochondrial oxidative stress. Front Genet 7: 165 (doi: 10.3389/fgene.2016.00165)

Philipp O, Osiewacz HD, Koch I (2016) Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins. Bioinformatics 32: 1427-1429

Ramallo Guevara C, Philipp O, Hamann A, Werner A, Osiewacz HD, Rexroth S, Rögner M, Poetsch A (2016) Global protein oxidation profiling suggests efficient mitochondrial proteasome homeostasis during ageing. Mol Cell Proteom 15: 1692-1709 (doi: 10.1074/mcp.M115.055616)

Warnsmann V, Hamann A, Osiewacz HD (2016) Im Alter zählt jeder Zentimeter: Mitochondrien und biologisches Altern. BIOspektrum 6: 571-574 (doi: 10.1007/s12268-016-0729-5)

Warnsmann V, Osiewacz HD (2016) Curcumin treatment affects mitochondrial respiration, induces autophagy and increases lifespan of the fungal aging model Podospora anserina. Endocytobiosis and Cell Res 27: 20-26

Wiemer M, Grimm C, Osiewacz HD (2016) Molecular control of fungal senescence and longevity. In: Wendland J (ed) The Mycota I, Growth, Differentiation and Sexuality, 3rd Edition. Springer International Switzerland, pp 155-181

Bernhardt D, Müller M, Reichert A, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5: 7885

Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV, Dötsch V, Osiewacz HD, Sreeramulu S, Schwalbe H (2015) Structure and biophysical characterization of the S-adenosylmethionine-dependent O-methyltransferase PaMTH1, a putative enzyme accumulating during senescence of Podospora anserina. J Biol Chem 26: 16415-16430.

Fischer F, Filippis C, Osiewacz HD (2015) RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model. Sci Rep 5: 12697 (doi: 10.1038/srep12697).

Fischer F, Langer JD, Osiewacz HD (2015) Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism. Sci Rep 5: 18375 (doi: 10.1038/srep18375).

Grimm C, Böhl L, Osiewacz HD (2015) Overexpression of Pa_1_10620 encoding a mitochondrial Podospora anserina protein with homology to superoxide dismutases and ribosomal proteins leads to lifespan extension. Curr Genet 61: 73-86 (doi: 10.1007/s00294-014-0446-x)

Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide. Exp Gerontol 63: 8-17 (doi: 10.1016/j.exger.2015.01.042).

Nyström T, Kennedy B, Osiewacz HD (2015) Microbial models. In: Vijg J, J Campisi, G Lithgow G (eds) Molecular and Cellular Biology of Aging, GSA, GSA Press eBook. Web, Washington DC, pp 49-82

Osiewacz HD (2015) Mitochondria and bioenergetics. In: Vijg J, J Campisi, G Lithgow G (eds) Molecular and Cellular Biology of Aging, GSA, GSA Press eBook. Web, Washington DC, 432-458

Bernhardt D, Hamann A, Osiewacz HD (2014) The role of mitochondria in fungal aging. Curr Opin Microbiol 22C: 1-7 (doi: 10.1016/j.mib.2014.09.007)

Knuppertz L, Hamann A, Pampaloni F, Stelzer E, Osiewacz HD (2014) Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina. Autophagy 10: 822-834 (doi: org/10.4161/auto.28148)

Plohnke N, Hamann A, Poetsch A, Osiewacz HD, Rögner M, Rexroth S (2014) Proteomic analysis of mitochondria from senescent Podospora anserina casts new light on ROS dependent aging mechanisms. Exp Gerontol 56: 13-25 (doi: 10.1016/j.exger.2014.02.008)

Wiemer M, Osiewacz HD (2014a) The proteasome activity reporter GFP-CI1 is degraded by autophagy in the aging model Podospora anserina. F1000Res 3: 230 (doi: 10.12688/f1000research.5337.1).

Wiemer M, Osiewacz HD (2014b)  Effect of paraquat-induced oxidative stress on gene expression and aging of the filamentous ascomycete Podospora anserina casts new light on ROS dependent aging mechanisms. Microbial Cell 1: 225-240 (doi: 10.15698/mic2014.07.155)

Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O (2013) Role of p38MAPD and oxidative stress in copper-induced senescence. AGE 35: 2255-2271.

Chimi MA, Dröse S, Wittig I, Heide H, Steger M, Werner A, Hamann A, Osiewacz HD, Brandt U (2013) Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS. J Proteomics 91: 358-374.

Daum B, Walter A, Horst A, Osiewacz HD, Kühlbrandt W (2013) Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. PNAS 110: 15301-15306.

Figge MT, Osiewacz HD, Reichert AS (2013) Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics? BioEssays 35: 314-322.

Fischer F, Weil A, Hamann A, Osiewacz HD (2013) Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain. Nature Commun 4: 1397 doi:10.1038/ncomms2397.

Gispert S, Parganlija D, Klinkenberg M, Dröse S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Büchel F, Adler T, Hrabé de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G (2013) Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. Hum Mol Genet 22: 4871-4887.

Osiewacz HD, Bernhardt D (2013) Mitochondrial quality control: impact on aging and life span. Gerontology 59: 413-420.

Osiewacz HD, Hamann A, Zintel S (2013) Assessing organismal aging in the filamentous fungus Podospora anserina. In: Galuzzi L et al (eds) Cell Senescence: Methods and Protocols. Methods Mol Biol 965: 439-462.

Philipp O, Hamann A, Servos J, Werner A, Koch I, Osiewacz HD (2013) A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina. PLoS ONE 8: e83109. doi: 10.1371/journal.pone.0083109.

Strobel I, Osiewacz HD (2013) Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina. Euk Cell 12: 900-912.

Figge MT, Reichert A, Meyer-Hermann M, Osiewacz HD (2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PloS Comput Biol 8: e1002576.

Fischer F, Hamann A, Osiewacz HD (2012) Mitochondrial quality control: an integrated network of pathways. Trends Biochem Sci 37: 284-292.

Kowald A, Hamann A, Zintel S, Ullrich S, Klipp E, Osiewacz HD (2012) A systems biological analysis links ROS metabolism to mitochondrial protein quality control. Mech Ageing Dev 133: 331-337.

Osiewacz HD, Scheckhuber CQ (2012) The basis of biological aging: Theories, models and mechanisms.In: Alt KW, de Jong W, Röder B (eds) Alter(n) anders denken. Kulturelle und biologische Perspektiven. Böhlau Verlag, Köln, Weimar, Wien, 359-369.

Scheckhuber CQ, Hamann A, Brust D, Osiewacz HD (2012) Cellular homeostasis in fungi: impact on the aging process. Subcell Biochem 57: 233-50.

Servos J, Hamann A, Grimm C, Osiewacz HD (2012) A differential genome-wide transcriptome analysis: Impact of cellular copper on complex biological processes like aging and development. PLoS ONE 7: e49292.

Rexroth S, Poetsch A, Rögner M, Hamann A, Werner A, Osiewacz HD, Schäfer ER, Seelert H, Dencher NA (2012) Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthase. Biochim Biophys Acta 1817: 381-387.

Davies KM, Strauss M, Daum B, Kief JH, Osiewacz HD, Rycovska A, Zickermann V, Kühlbrandt W (2011) Macromolecular organization of ATP synthase and complex I in whole mitochondria. PNAS 108: 14121-14126.

Müller-Ohldach M, Brust D, Hamann A, Osiewacz HD (2011) Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging. Mech Ageing Dev 132: 33-42.

Osiewacz HD (2011) Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina. Biochem Soc Trans 39: 1488-1492.

Scheckhuber CQ, Houthoofd K, Weil AC, Werner A, De Vreese A, Vanfleteren JR, Osiewacz HD (2011) Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the ageing model Podospora anserina. PLoS One 6: e16620.

Scheckhuber CQ, Wanger RA, Mignat CA, Osiewacz HD (2011) Unopposed mitochondrial fission leads to severe lifespan shortening. Cell Cycle 10: 3105-3110.

Weil A , Luce K, Dröse S, Wittig I, Brandt U, Osiewacz HD (2011) Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development. Cell Cycle 10: 4280-4290.

Zintel S, Bernhardt D, Rogowska-Wrzesinska A, Osiewacz HD (2011) PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress. Aging 3: 768-781.

Blagosklonny MV., Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM. Jr, Brunet A, DePinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkow AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J (2010) Impact papers on aging in 2009. Aging 2: 111-121.

Brust D, Daum B, Breunig C, Hamann A, Kühlbrandt W, Osiewacz HD (2010) Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. Aging Cell 9: 761-775.

Brust D, Hamann A, Osiewacz HD (2010) Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension. Curr Genet 56: 225-235.

Knab B, Osiewacz HD (2010) Methylation of polyphenols with vicinal hydroxyl groups: A protection pathway increasing organismal lifespan. Cell Cycle 9: 3386-3387.

Luce K, Weil AC, Osiewacz HD (2010) Mitochondrial protein quality control systems in aging and disease. In: Tavernarakis N (ed) Protein metabolism and homeostasis in aging. Landes Bioscience and Springer Science+Business Media: 109-125.

Müller-Ohldach M, Brust D, Hamann A, Osiewacz HD (2010) Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging. Mech Ageing Dev 132: 33-42.

Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HD, Pöggeler S, Read ND, Seiler S, Smith KM, Zickler D, Kück U, Freitag M (2010) De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. PLoS Genet. 6: e1000891.

Osiewacz HD (2010) Role of mitochondria in aging and age-related disease. Exp Gerontol 45: 465.

Osiewacz HD, Brust D, Hamann A, Kunstmann B, Luce K, Müller-Ohldach M, Scheckhuber CQ, Servos J, Strobel I (2010) Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina. Ann NY Acad Sci 1197: 54-66.

Scheckhuber CQ, Mack SJ, Strobel I, Ricciardi F, Gispert S, Osiewacz HD (2010) Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. Aging 2: 969-980.

Zintel S, Schwitalla D, Luce K, Hamann A, Osiewacz HD (2010) Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening. Exp Gerontol 45: 525-532.

Hamann A, Osiewacz HD (2009) Apoptose - Programmierter Zelltod im Reich der Pilze. BIOSpektrum 1: 20-22.

Kunstmann B, Osiewacz HD (2009) The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress. AGING 1: 1-7.

Luce K, Osiewacz HD (2009) Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol 11: 852-858.

Scheckhuber CQ (2009) Impact of mitochondrial dynamics on organismic aging. Scientific World Journal 9: 250-254.

Scheckhuber CQ, Grief J, Boilan E, Luce K, Debacq-Chainiaux F, Rittmeyer C, Gredilla R, Kolbesen BO, Toussaint O, Osiewacz HD (2009) Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts. PLoS ONE 4: e4919.

Scheckhuber CQ, Mitterbauer R, Osiewacz HD (2009) Molecular basis of and interference into degenerative processes in fungi: potential relevance for improving biotechnological performance of microorganisms. Appl Microbiol Biotechnol 85: 27-35.

Soerensen M, Gredilla R, Müller-Ohldach M, Werner A, Bohr VA, Osiewacz HD, Stevnsner T (2009) A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing. Mech Ageing Dev 130: 487-496.

Strobel I, Breitenbach J, Scheckhuber CQ, Osiewacz HD, Sandmann G (2009) Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium. Curr Genet 55: 175-184.

Hamann A, Brust D, Osiewacz HD (2008) Apoptosis pathways in fungal growth, development and ageing. Trends Microbiol 16: 276-283.

Kunstmann B, Osiewacz HD (2008) Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended life span of Podospora anserina without impairments in vital functions. Aging Cell 7: 651-662.

Osiewacz HD, Scheckhuber CQ (2008) Reactive oxygen species in molecular pathways controlling aging in the filamentous fungus Podospora anserina. In: Miwa S, Beckman KB, Muller FL (eds) Oxidative Stress in Aging. From Model Systems to Human Diseases. Humana Press, Totowa: 53-65.

Scheckhuber CQ, Osiewacz HD (2008) Podospora anserina - A model organism to study mechanisms of healthy ageing. Mol Genet Genomics 280: 365-374.

Scheckhuber CQ, Rödel E, Wüstehube J (2008) Regulation of mitochondrial dynamics - characterization of fusion and fission genes in the ascomycete Podospora anserina. Biotechnol J 3: 781-790.

Groebe K, Krause F, Kunstmann B, Unterluggauer H, Reifschneider NH, Scheckhuber CQ, Sastri C, Stegmann W, Wozny W, Schwall GP, Poznanovic S, Dencher NA, Jansen-Dürr P, Osiewacz HD, Schrattenholz A (2007) Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes. Exp Gerontol 42: 887-898.

Hamann A, Brust D, Osiewacz HD (2007) Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina. Mol Microbiol 65: 948-958.

Scheckhuber CQ, Erjavec N, Tinazli A, Hamann, A, Nyström T, Osiewacz HD (2007) Reducing mitochondrial fission results in increased lifespan and fitness of two fungal ageing models. Nature Cell Biology 9: 99-105.

Gredilla R, Grief J, Osiewacz HD (2006) Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina. Exp Gerontol 41: 239-247.

Hunzinger C, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Zengerling H, Schoepf R, Groebe K, Cahill MA, Osiewacz HD, Jägemann N, Bloch M, Dencher NA, Krause F Schrattenholz A (2006) Comparative profiling of the mammalian mitochondrial proteome: multiple aconitase-2 isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species. J Proteome Res 5: 625-633.

Krause F, Scheckhuber CQ, Werner A, Rexroth S, Reifschneider NH, Dencher NA, Osiewacz HD (2006) OXPHOS supercomplexes: Respiration and life-span control in the aging model Podospora anserina. Ann N Y Acad Sci 1067: 106-115.

Osiewacz HD, Scheckhuber CQ (2006) Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina. Free Radical Res 40: 1350-1358.

Hamann A, Krause K, Werner A, Osiewacz HD (2005) A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina. Curr Genet 48: 270-275.

Hamann A, Osiewacz HD (2004) Genetic analysis of spore killing in the filamentous ascomycete Podospora anserina. Fungal Genet Biol 41: 1088-1098.

Krause F, Scheckhuber CQ, Werner A, Rexroth S, Reifschneider NH, Dencher NA, Osiewacz HD (2004) Supramolecular organization of COX- and AOX-dependent respiratory chains in the filamentous fungus Podospora anserina. J Biol Chem 279: 26453-26461.

Osiewacz HD (2004) Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina. In: Nyström T, Osiewacz HD (eds.): Model systems in ageing. Springer, Heidelberg, New York, Tokyo, pp 17-38.

Osiewacz HD, Hamann A (2004) Senescence and longevity. In: Kües U, Fischer R (Vol. eds.): The Mycota I, 2nd Edition. Springer, Heidelberg, New York, Tokyo, pp 189-200.

Stumpferl SW, Stephan O, Osiewacz HD (2004) Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina . Euk Cell 3: 200-211.

Osiewacz HD (2003) Ageing and longevity in the filamentous fungus Podospora anserina. In: Osiewacz HD (Volume Editor): Aging of the organisms. Kluwer Academic Publisher, Dordrecht, The Netherlands, pp 31-53.

Borghouts C, Scheckhuber CQ, Stephan O, Osiewacz HD (2002) Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter. Int J Biochem Cell Biol 34: 1355-1371.

Borghouts C, Scheckhuber CQ, Werner A, Osiewacz HD (2002) Respiration, copper availability and SOD activity in Podospora anserina strains with different lifespan. Biogerontol 3: 143-153.

Osiewacz HD (2002a) Genes, mitochondria and aging in filamentous fungi. Ageing Res Rev 28: 425-441.

Osiewacz HD (2002b) Aging in fungi: role of mitochondria in Podospora anserina. Mech Ageing Dev 123: 755-764.

Osiewacz HD (2002c) Mitochondrial functions and aging. Gene 286: 65-71.

Osiewacz HD, Scheckhuber CQ (2002) Senescence in Podospora anserina. In: Osiewacz HD (ed.) Molecular Biology of Fungal Development. Marcel Dekker, New York, pp 87-108.

Averbeck N, Borghouts C, Hamann A, Specke V, Osiewacz HD(2001) Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina. Mol Gen Genet 264: 604-612.

Borghouts C, Werner A, Elthon T, Osiewacz HD (2001) Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol Cell Biol 21: 390-399.

Osiewacz HD, Stumpferl SW (2001) Metabolism and aging in the filamentous fungus Podospora anserina. Arch Gerontol Geriatrics 32: 185-198.

Averbeck N, Jensen ON, Mann M, Schägger H, Osiewacz HD (2000) Identification and characterization of PaMTH1, a putative O-methyltransferase accumulating during senescence of Podospora anserina cultures. Curr Genet 3: 200-208.

Borghouts C, Kerschner S, Osiewacz HD (2000) Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina. Curr Genet 4: 268-275.

Borghouts C, Osiewacz HD (2000) Nuclear-mitochondrial interactions involved in aging in Podospora anserina. Ann NY Acad Sci 908: 291-294.

Hamann A, Feller F, Osiewacz HD (2000a) The degenerate DNA transposon Pat and repeat-induced point mutation (RIP) in Podospora anserina . Mol Gen Genet 263: 1061-1069.

Hamann A, Feller F, Osiewacz HD (2000b) Yeti – a degenerate gypsy-like LTR retrotransposon in the filamentous ascomycete Podospora anserina . Curr Genet 38: 132-140.

Osiewacz HD (2000) The genetic basis of aging in the fungal aging model Podospora anserina. Futura 15: 237-241.

Osiewacz HD, Borghouts C (2000a) Mitochondrial oxidative stress and aging in the filamentous fungus Podospora anserina. In: Toussaint O, Osiewacz HD, Lithgow G, Brack C (eds): Molecular and Cellular Gerontology. Ann NY Acad Sci 908, 31-39.

Osiewacz HD, Borghouts C (2000b) Cellular Copper homeostasis, mitochondrial DNA instabilities, and lifespan control in the filamentous fungus Podospora anserina. Exp Gerontol 35: 677-686.

Khashnobish A, Hamann A, Osiewacz HD (1999) Modulation of gene expression by (CA)n microsatellites in the filamentous fungus Podospora anserina. Appl Microbiol Biotechnol 52: 191-195.

Kimpel E, Osiewacz HD (1999) PaGrg1 , a glucose repressible gene of Podospora anserina that is differentially expressed during lifespan. Curr Genet 35: 557-563.

Osiewacz HD (1999) Fondamenti genetici dell'invecchiamento biologico. In: Colantonio R, Lucchetti M, Venturelli A (eds).Ambiente e invecchiamento. Politiche e strategie di ricerca in Germania e in Italia.Edizioni Angelo Guerini e Associati SpA. Mailand, pp 117-125.

Osiewacz HD, Kimpel E (1999) Mitochondrial-nuclear interactions and lifespan control in fungi. Exp Gerontol 34: 901-909.

Borghouts C, Osiewacz HD (1998) GRISEA, a copper-modulated transcription factor of Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae .Mol Gen Genet 260: 492-502.

Hamann A, Osiewacz HD (1998) Genome analysis of filamentous fungi: Identification and characterization of an unusual GT-rich minisatellite in the ascomycete Podospora anserina . Curr Genet 34: 88-92.

van der Gaag M, Debets AJM, Osiewacz HD, Hoekstra RF (1998) The dynamics of pAL2-1 homologous linear plasmids Podospora anserina . Mol Gen Genet 258: 521-529.

Borghouts C, Kimpel E, Osiewacz HD (1997) Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea . Proc Natl Acad Sci USA 94: 10768-10773.Osiewacz HD (1997) Genetic regulation of aging. J Mol Med 75 : 715-727.

Osiewacz HD, Hamann A (1997) DNA reorganization and biological aging. A review. Biochemistry (Moscow) 62: 1275-1284.

Pöggeler S, Risch S, Kück U, Osiewacz HD (1997) Mating-type genes from the homothallic fungus Sordaria macrospora are functionally expressed in a heterothallic ascomycete. Genetics 147: 567-580.

Hermanns J, Osiewacz HD (1996) Induction of longevity by cytoplasmic transfer of a linear plasmid in Podospora anserina . Curr Genet 29: 250-256.

Osiewacz HD (1996a) Extrachromosomal and transposable genetic elements. In: Bos CJ (ed) Fungal Genetics . Marcel Dekker, New York, pp 177-208.

Osiewacz HD (1996b) Genetic analysis of senescence in Podospora anserina . In: Bos CJ (ed) Fungal Genetics . Marcel Dekker, New York, pp 317-335.

Osiewacz HD (1996c) Nuclear-mitochondrial interactions involved in biological aging. In: Rattan SIS, Toussaint O (eds) Molecular Gerontology, Plenum Press, New York, pp 37-52.

Osiewacz HD, Hamann A, Werner A (1996) Genome analysis of filamentous fungi: identification of a highly conserved simple repetitive sequence in different strains of Podospora anserina . Microbiol Res 151: 1-8.

Osiewacz HD, Nuber U (1996) GRISEA, a putative copper-activated transcription factor of Podospora anserina involved in differentiation and senescence. Mol Gen Genet 252: 115-124.

Schwartz T, Osiewacz HD (1996) Telomere length does not change during senescence of the ascomycete Podospora anserina . Mutat Res 316: 193-199.

Hermanns J, Asseburg A, Osiewacz HD (1995) Evidence for giant linear plasmids in the ascomycete Podospora anserina . Curr Genet 27: 379-386.

Hermanns J, Debets F, Hoekstra R, Osiewacz HD (1995) A novel family of linear plasmids. Mol Gen Genet 246: 638-647.

Johnson T, Arking R, Bertrand H, Driscoll M, Esser K, Griffiths A, Harley C, Jazwinski SM, Kirkwood T, Osiewacz (1995) Research on diverse model systems and the genetic basis of aging and longevity. In: Esser K, Martin GM (eds) Molecular Aspects of Aging , Wiley & Sons, Chichester, pp 62-76.

Osiewacz HD (1995a) Aging and genetic instabilities. In: Esser K, Martin GM (eds) Molecular Aspects of Aging.Wiley & Sons, Chichester, pp 29-44.

Osiewacz HD (1995b) Molekulare Mechanismen biologischen Alterns. BiuZ 25: 336-344.

Bürkle A, Osiewacz HD (1994) Altern von makromolekularen Substanzen der Zelle - Nukleinsäuren. In: Olbrich E, Sames K, Schramm A (eds) Kompendium der Gerontologie. Ecomed Verlag, Landsberg, Kap. IV - 2.1.2.1: 1-9.

Hermanns J, Asseburg A, Osiewacz HD (1994) Evidence for a life span-prolonging effect of a linear plasmid in a longevity mutant of Podospora anserina. Mol Gen Genet 243: 297-307.

Hermanns J, Osiewacz HD (1994) Three mitochondrial unassigned open reading frames of Podospora anserina represent remnants of a viral-type RNA polymerase gene. Curr Genet 25: 150-157.

Kruip J, Nixon PJ, Osiewacz HD, Rögner M (1994) Nucleotide sequence of the petB gene encoding cytochrome b6 from the mesophilic cyanobacterium Synechocystis PCC 6803: implications for evolution and function. Biochim Biophys Acta 1188: 443-446.

Osiewacz HD (1994a) Auf der Suche nach den Alternsgenen. Einblick 4: 10-13.

Osiewacz HD (1994b) Biologisches Altern und mitochondriale DNA-Instabilitäten. Bioscope 2: 21-28.

Osiewacz HD (1994c) Modellsysteme in der experimentellen Alternsforschung. In: Neises M, Wischnik A, Melchert F (eds) Der Geriatrische Tumorpatient.Karger, Basel Freiburg Paris London New York New Delhi Bangkok Singapore Tokyo Sidney: 25-32.

Osiewacz HD (1994d) A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes. Curr Genet 26: 87-90.

Mohamed A, Eriksson J, Osiewacz HD, Jansson C (1993) Differential expression of the psbA genes in the cyanobacterium Synechocystis 6803. Mol Gen Genet 238: 161-168.

Osiewacz HD (1993) Fungi as model systems in experimental gerontolology.In: Deutsches Krebsforschungszentrum (ed) Current Cancer Research 1992. Steinkopff-Verlag, Darmstadt, Springer-Verlag, New York: 147-151.

Hermanns J, Osiewacz HD (1992) The linear mitochondrial plasmid pAL2-1 of a long-lived Podospora anserina mutant is an invertron encoding a DNA and RNA polymerase. Curr Genet 22: 491-500.

Kempken F, Hermanns J, Osiewacz HD (1992) Evolution of linear plasmids. J Mol Evol 35: 502-513.

Osiewacz HD (1992a) Genetic control of aging in the ascomycete Podospora anserina. In: Zwilling R, Balduini C (eds) Biology of Aging. Springer-Verlag, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest: 153-164.

Osiewacz HD (1992b) Experimentelle Alternsforschung - Pilze als Modellsysteme. In: Deutsches Krebsforschungszentrum (ed) Krebsforschung heute. Steinkopff-Verlag, Darmstadt: 165-170.

Osiewacz HD (1992c) Construction of insertion mutants of Synechocystis sp. PCC 6803: evidence for an essential function of subunit IV of the cytochrome b6/f complex. Arch Microbiol 157: 336-342.

Osiewacz HD, Hermanns J (1992) The role of mitochondrial DNA rearrangements in aging and human diseases. Aging Clin Exp Res 4: 273-286.

Ridder R, Osiewacz HD (1992) Sequence analysis of the gene coding for glyceraldehyde-3-phosphate dehydrogenase (gpd) of Podospora anserina: use of homologous regulatory sequences to improve transformation efficiency. Curr Genet 21: 207-213.

Gurevitz M, Osiewacz HD, Keren Y (1991) Molecular evidence for interchromosomal recombination in the cyanobacterium Synechocystis sp. PCC 6803. Plant Sci 78: 217-224.

Osiewacz HD, Ridder R (1991) Genome analysis of imperfect fungi: electrophoretic karyotyping and characterization of the nuclear gene coding for glyceraldehyde-3-phosphate dehydrogenase (gpd) of Curvularia lunata. Curr Genet 20: 151-155.

Osiewacz HD, Skaletz A, Esser K (1991) Integrative transformation of the ascomycete Podospora anserina: identification of the mating-type locus on chromosome VII of electrophoretically separated chromosomes. Appl Microbiol Biotechnol 35: 38-45.

Ridder R, Künkele K-P, Osiewacz HD (1991) Sequence of the nuclear ATP synthase subunit 9 gene of Podospora anserina: lack of similarity to the mitochondrial genome. Curr Genet 20: 349-351.

Osiewacz HD (1990) Molecular analysis of aging processes in fungi. Mutat Res 237: 1-8.

Osiewacz HD, Clairmont A, Huth M (1990) Electrophoretic karyotype of the ascomycete Podospora anserina. Curr Genet 18: 481-483.

Osiewacz HD, Heinen U (1989) Recombination of mobile genetic elements from plants and cyanobacteria. Prog Bot 50: 174-197.

Osiewacz HD, Hermanns J, Marcou D, Triffi M, Esser K (1989) Mitochondrial DNA rearrangements are correlated with a delayed amplification of the mobile intron (plDNA) in a long-lived mutant of Podospora anserina. Mutat Res 219: 9-15.

Osiewacz HD, Weber A (1989) DNA mediated transformation of the filamentous fungus Curvularia lunata using a dominant selectable marker. Appl Microbiol Biotechnol 30: 375-380.

Jansson C, Debus RJ, Osiewacz HD, Gurevitz M, McIntosh L (1987) Construction of an obligate photoheterotrophic mutant of the cyanobacterium Synechocystis 6803: inactivation of the psbA gene family. Plant Phys 85: 1021-1025.

Osiewacz HD, McIntosh L (1987) Nucleotide sequence of a member of the psbA multigene family from the unicellular cyanobacterium Synechocystis 6803. Nucleic Acids Res 15: 10585.

Böckelmann B, Osiewacz HD, Schmidt FR, Schulte E (1986) Extrachromosomal DNA in fungi-organization and function. In: Buck KW (ed) Fungal Virology.CRC Press, Boca Raton, Florida: 237-283.

Osiewacz HD (1986) Recombination in cyanobacteria and lower plants after vector-mediated DNA transfer. Prog Bot 48: 224-240.

Kück U, Osiewacz HD, Schmidt U, Kappelhoff B, Schulte E, Stahl U, Esser K (1985) The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina. Curr Genet 9: 373-382.

Osiewacz HD, Esser K (1984) The mitochondrial plasmid of Podospora anserina: a mobile intron of a mitochondrial gene. Curr Genet 8: 299-305.

Osiewacz HD, Esser K (1983) DNA sequence analysis of the mitochondrial plasmid of Podospora anserina. Curr Genet 7: 219-223.

Books

Osiewacz HD (Volume Editor) (2014) Progress in Molecular Biology and Translational Science, Volume 127: The Mitochondrion in Aging and Disease. Academic Press, Amsterdam, Heidelberg.

Nyström T, Osiewacz HD (Volume Editors) (2004) Model Systems in Aging. Springer, Heidelberg New York, Tokyo.

Osiewacz HD (Volume Editor) (2003) Aging of Organisms. Kluwer Academic Publisher, Dordrecht.

Osiewacz HD (Volume Editor) (2002 a) Molecular Biology of Fungal Development. Marcel Dekker, New York.

Osiewacz HD (Volume Editor) (2002b) The Mycota, Volume X: Industrial Applications. Springer, Heidelberg New York Tokyo

Toussaint O, Osiewacz HD, Lithgow G, Brack C (eds) (2000) Molecular and Cellular Gerontology. Ann. N.Y. Acad. Sci., 908.

Esser K, Kück U, Lang-Hinrichs C, Lemke P, Osiewacz HD, Stahl U, Tudzynski P (1986) Plasmids of eukaryotes. Fundamentals and applications. Springer Science Library. Springer, Heidelberg New York Tokyo

Osiewacz HD (1984): Mitochondriale Mosaikgene: Strukturaufklärung eines mobilen Introns aus dem Ascomyceten Podospora anserina. Bibliotheca Mycologica Bd. 94. Cramer, Vaduz

Congress Reports

Scheckhuber C, Osiewacz HD (2006) The Role of Mitochondria in Conserved Mechanisms of Aging. Sci Aging Knowledge Environ 2006 (10), pp. pe. 15.

Scheckhuber C (2005a) Mitochondrial Dynamics in Cell Life and Death. Sci Aging Knowledge Environ 47: 36.

Scheckhuber C (2005b) Report on the 14th Annual Meeting of the German Society for Geriatric Research. Sci Aging Knowledge Environ. 1: 1.

Scheckhuber C, Osiewacz HD (2005) MiMage: a pan-European project on the role of mitochondria in aging. Sci Aging Knowledge Environ 20: 14.

Jansen-Dürr P, Osiewacz HD (2002) Healthy ageing: a question of stress, damage and repair: Meeting on mechanisms on biological ageing. EMBO Rep 3: 1127-1132.

Brack C, Lithgow G, Osiewacz H, Toussaint O (2000) EMBO Workshop Report: Molecular and cellular gerontology, Serpiano, Switzerland, September 17-22, 1999, EMBO J 19: 1-6.

Kontakt

Prof. Dr. Heinz D. Osiewacz
Biozentrum, Campus Riedberg
Max-von-Laue-Str. 9
60438 Frankfurt am Main

F +49 69 798-29363
E osiewacz@bio.uni-frankfurt.de


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